| Name | GRP78 |
|---|---|
| Synonyms | 78 kDa glucose regulated protein; MIF 2; MIF2; 78 kDa glucose regulated protein precursor; BIP; Endoplasmic reticulum lumenal Ca(2+) binding protein grp78; GRP 78; GRP78… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17915553 | Falahatpisheh H, Nanez A, Montoya-Durango D, Qian Y, Tiffany-Castiglioni E, Ramos KS: Activation profiles of HSPA5 during the glomerular mesangial cell stress response to chemical injury. Cell Stress Chaperones. 2007 Autumn;12(3):209-18. |
9(0,0,0,9) | Details |
| 17937580 | Dickhout JG, Sood SK, Austin RC: Role of endoplasmic reticulum disequilibria in the mechanism of -induced ER stress. Antioxid Redox Signal. 2007 Nov;9(11):1863-73. Prevention of the -induced UPR by cycloheximide pretreatment normalized GRP78 expression and ER-Ca (2+) emptying evoked by thapsigargin. |
7(0,0,1,2) | Details |
| 17067731 | Kumagai K, Ando Y, Kiyosawa N, Ito K, Kawai R, Yamoto T, Manabe S, Teranishi M: Toxicoproteomic investigation of the molecular mechanisms of cycloheximide-induced hepatocellular apoptosis in rat liver. Toxicology. 2006 Dec 7;228(2-3):299-309. Epub 2006 Sep 29. Toxicoproteomics using two-dimensional difference gel electrophoresis and mass spectrometry indicated that GRP78/Bip was inactivated by the CHX treatment. |
1(0,0,0,1) | Details |
| 17283163 | Little JL, Wheeler FB, Fels DR, Koumenis C, Kridel SJ: Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. Cancer Res. 2007 Feb 1;67(3):1262-9. Induction of ER stress is further confirmed by the increased expression of the ER stress-regulated genes CHOP, ATF4, and GRP78. FAS inhibitor-induced ER stress is activated prior to the detection of caspase 3 and PARP cleavage, primary indicators of cell death, whereas orlistat-induced cell death is rescued by coincubation with the global translation inhibitor cycloheximide. |
1(0,0,0,1) | Details |
| 16219389 | Fukushima T, Koide M, Ago Y, Baba A, Matsuda T: T-817MA, a novel neurotrophic agent, improves sodium nitroprusside-induced mitochondrial dysfunction in cortical neurons. Neurochem Int. 2006 Jan;48(2):124-30. Epub 2005 Oct 10. The effects of T-817MA on SNP-induced decrease in cell viability and SNP-induced increase in mitochondrial ROS production were blocked by cycloheximide. SNP-induced neuronal toxicity was accompanied by a decrease in mitochondrial transmembrane potential without an increase in the expression of CHOP and GRP78 mRNAs, endoplasmic reticulum stress makers. |
1(0,0,0,1) | Details |
| 19665696 | Oguma T, Ono T, Kajiwara T, Sato M, Miyahira Y, Arino H, Yoshihara Y, Tadakuma T: CD4 (+) CD8 (+) thymocytes are induced to cell death by a small dose of puromycin via ER stress. Cell Immunol. 2009;260(1):21-7. Epub 2009 Jul 14. The induction of apoptosis was blocked by the protein synthesis inhibitor cycloheximide, and to some extent by transfection of Bcl-xL or Bcl-2 genes. Expression of GRP78 was up-regulated after treatment with a small dose of puromycin, and the cell death by puromycin was blocked in the presence of caspase 12 inhibitor. |
1(0,0,0,1) | Details |
| 20054003 | McLaughlin M, Alloza I, Quoc HP, Scott CJ, Hirabayashi Y, Vandenbroeck K: Inhibition of secretion of interleukin (IL)-12/IL-23 family cytokines by 4-trifluoromethyl- is coupled to degradation via the endoplasmic reticulum stress protein HERP. J Biol Chem. 2010 Mar 5;285(10):6960-9. Epub 2010 Jan 6. Both HERP siRNA knockdown and HERP overexpression coupled to cycloheximide chase assays revealed that HERP is necessary for degradation of intracellularly retained p80 by TFM-C. This revealed that TFM-C induced 1.5-3-fold transcriptional up-regulation of calreticulin, GRP78, GRP94, GRP170, ERp72, ERp57, ERdj4, and ERp29. |
1(0,0,0,1) | Details |