| Name | Hsp90 |
|---|---|
| Synonyms | HSP 86; LAP 2; LAP2; HSP86; HSP90A; HSP90AA1; HSP90N; HSPC 1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15684389 | Salerno M, Palmieri D, Bouadis A, Halverson D, Steeg PS: Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells. Mol Cell Biol. 2005 Feb;25(4):1379-88. Cells expressing high levels of Nm23-H1 exhibited increased KSR1 degradation in the presence of either cycloheximide or an Hsp90-directed drug currently in clinical trial, 17-allylamino-17-demethoxygeldanamycin (17-AAG). |
82(1,1,1,2) | Details |
| 19737590 | Yoshikawa N, Nemoto T, Satoh S, Maruta T, Yanagita T, Chosa E, Wada A: Distinct regulation of insulin receptor substrate-1 and -2 by 90-kDa heat-shock protein in chromaffin cells. Neurochem Int. 2010 Jan;56(1):42-50. Epub 2009 Sep 6. The 90-kDa heat-shock protein (Hsp90) is an emerging target molecule of therapeutics, Hsp90 inhibitors being promising against various diseases (e.g., cancer, brain and cardiac ischemia, and neurodegenerative diseases). Geldanamycin-induced increase of insulin receptor substrate-2 was prevented by cycloheximide or actinomycin D. |
5(0,0,0,5) | Details |
| 16821709 | Papamichael K, Vovou I, Miligkos V, Stavrinidis E, Delitheos A, Tiligada E: Effect of the Hsp90 modulators on the heat-shock response in eukaryotic cells. Folia Microbiol. 2006;51(1):33-7. Upon short-term preconditioning, both Hsp90 inhibitors conferred cycloheximide-dependent thermal resistance to the yeast cultures, while upon long-term treatment the induction of thermotolerance was confined only to AAG. |
33(0,1,1,3) | Details |
| 16099423 | Nomura M, Nomura N, Yamashita J: Geldanamycin-induced degradation of Chk1 is mediated by proteasome. Biochem Biophys Res Commun. 2005 Sep 30;335(3):900-5. Checkpoint kinase 1 (Chk1) is a cell cycle regulator and a heat shock protein 90 (Hsp90) client. Co-treatment with GA and cycloheximide (CHX), a protein synthesis inhibitor, induced a decrease of half-life of the Chk1 protein to 3h and resulted in Chk1 down-regulation. |
2(0,0,0,2) | Details |
| 16719951 | Isaji M, Iwata H, Harayama H, Miyake M: The localization of LAP2 beta during pronuclear formation in bovine oocytes after fertilization or activation. Zygote. 2006 May;14(2):157-67. We have shown that the assembly of lamin-associated polypeptide (LAP) 2beta was detected surrounding the chromatin mass around the time of extrusion of the second polar body (PB) in some fertilized oocytes, but not in most activated oocytes, by using A23187 and cycloheximide (CaA + CH). |
1(0,0,0,1) | Details |
| 15802049 | Baggett B, Roy R, Momen S, Morgan S, Tisi L, Morse D, Gillies RJ: Thermostability of firefly luciferases affects efficiency of detection by in vivo bioluminescence. Mol Imaging. 2004 Oct;3(4):324-32. Luciferase transfected mammalian cells were used to determine in vivo half-lives following cycloheximide inhibition of de novo protein synthesis. This may be due to a variety of factors, including chaperone activity, as steady-state luciferase levels were reduced by geldanamycin, an Hsp90 inhibitor. |
1(0,0,0,1) | Details |
| 17172411 | Lee JH, Park JH, Jung Y, Kim JH, Jong HS, Kim TY, Bang YJ: Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells. Mol Cancer Ther. 2006 Dec;5(12):3085-95. Cotreatment with trichostatin A and cycloheximide restored TS mRNA expression, suggesting that TS mRNA is repressed through new protein synthesis. Mechanistically, TS protein was found to interact with heat shock protein (Hsp) complex, and trichostatin A treatment induced chaperonic Hsp90 acetylation and subsequently enhanced Hsp70 binding to TS, which led to the proteasomal degradation of TS protein. |
1(0,0,0,1) | Details |
| 16210633 | Vega VL, De Maio A: Increase in phagocytosis after geldanamycin treatment or heat shock: role of heat shock proteins. J Immunol. 2005 Oct 15;175(8):5280-7. An increase in the phagocytosis of opsonized bacteria particles and latex beads was observed upon incubation of murine macrophages with geldanamycin (GA), a specific inhibitor of the Hsp90 family of proteins. The effect of GA on phagocytosis was blocked by coincubation with inhibitors of transcription (actinomycin D) or translation (cycloheximide), suggesting that gene expression was required. |
1(0,0,0,1) | Details |