Protein Information

Name STAT5
Synonyms STAT 5; STAT5; STAT5B; Signal transducer and activator of transcription 5B; Signal transducer and activator of transcription 5Bs

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
16985255 Floyd ZE, Segura BM, He F, Stephens JM: Degradation of STAT5 proteins in 3T3-L1 adipocytes is induced by TNF-{alpha} and cycloheximide in a manner independent of STAT5A activation. Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E461-8. Epub 2006 Sep 19.

Initial characterization of the TNF-alpha and cycloheximide-mediated degradation of STAT5 indicates that inhibition of the proteasome stabilizes both forms of STAT5 in the presence of TNF-alpha.
228(2,4,4,8) Details
16988072 Story DJ, Stephens JM: Modulation and lack of cross-talk between signal transducer and activator of transcription 5 and Suppressor of cytokine signaling-3 in insulin and growth hormone signaling in 3T3-L1 adipocytes. Obesity (Silver Spring). 2006 Aug;14(8):1303-11.


OBJECTIVE: To examine the role of signal transducer and activator of transcription (STAT) 5 and suppressor of cytokine signaling (SOCS)-3 in the cross-talk between growth hormone and insulin (INS) signaling in fat cells.
2(0,0,0,2) Details
16951370 Rahman MS, Yamasaki A, Yang J, Shan L, Halayko AJ, Gounni AS: IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells: role of MAPK (Erk1/2, JNK, and p38) pathways. J Immunol. 2006 Sep 15;177(6):4064-71.


Moreover, IL-17A significantly induced eotaxin-1/CCL11 release and mRNA expression, an effect that was abrogated with cycloheximide and actinomycin D treatment.
0(0,0,0,0) Details