Protein Information

Name angiotensin II
Synonyms AGT; ANG II; ANHU; Angiotensin I; Angiotensin II; Angiotensinogen; Angiotensinogen precursor; SERPINA 8…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
17379189 Weisinger G, Limor R, Marcus-Perlman Y, Knoll E, Kohen F, Schinder V, Firer M, Stern N: 12S-lipoxygenase protein associates with alpha-actin fibers in human umbilical artery vascular smooth muscle cells. Biochem Biophys Res Commun. 2007 May 11;356(3):554-60. Epub 2007 Mar 12.

Upon angiotensin-II treatment of cultured VSMC, immunoprecipitated 12-LO was found bound to alpha-actin, a component of the cytoplasmic myofilaments. 12-LO/alpha-actin binding was blocked by VSMC pretreatment with the 12-LO inhibitors, baicalien or esculetine and the protein synthesis inhibitor, cycloheximide.
33(0,1,1,3) Details
19158234 Nogueira EF, Xing Y, Morris CA, Rainey WE: Role of angiotensin II-induced rapid response genes in the regulation of enzymes needed for aldosterone synthesis. J Mol Endocrinol. 2009 Apr;42(4):319-30. Epub 2009 Jan 21.

7(0,0,0,7) Details
20339118 Montezano AC, Burger D, Paravicini TM, Chignalia AZ, Yusuf H, Almasri M, He Y, Callera GE, He G, Krause KH, Lambeth D, Quinn MT, Touyz RM: Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells. Circ Res. 2010 Mar 25.

Effects were inhibited by actinomycin D and cycloheximide and blunted by diltiazem, calmidazolium and low extracellular Ca (2+) ([Ca (2+)] e).
7(0,0,0,7) Details
15666812 Clark BJ, Li J: Janus kinase 2 signaling in the angiotensin II-dependent activation of StAR expression. Endocr Res. 2004 Nov;30(4):685-93.

The Ang II-dependent, but not (Bu) 2cAMP-dependent, induction of StAR mRNA was also blocked by AG490 and shown to be sensitive to cycloheximide treatment.
6(0,0,0,6) Details
18055484 Nogueira EF, Vargas CA, Otis M, Gallo-Payet N, Bollag WB, Rainey WE: Angiotensin-II acute regulation of rapid response genes in human, bovine, and rat adrenocortical cells. J Mol Endocrinol. 2007 Dec;39(6):365-74.

Pretreatment of H295R cells with cycloheximide had no effect on Ang-II induction of these genes, suggesting that they are direct targets of Ang-II signaling.
6(0,0,0,6) Details
15569273 Luo G, Xu CB, Cao YX, Edvinsson L: Transcriptional up-regulation in expression of 5-hydroxytryptamine2A and transcriptional down-regulation of angiotensin II type 1 receptors during organ culture of rat mesenteric artery. Basic Clin Pharmacol Toxicol. 2004 Dec;95(6):280-7.

5(0,0,0,5) Details
19396617 Carraro-Lacroix LR, Girardi AC, Malnic G: Long-term regulation of vacuolar H (+)-ATPase by angiotensin II in proximal tubule cells. Pflugers Arch. 2009 Sep;458(5):969-79. Epub 2009 Apr 26.

5(0,0,0,5) Details
15939809 Clasen R, Schupp M, Foryst-Ludwig A, Sprang C, Clemenz M, Krikov M, Thone-Reineke C, Unger T, Kintscher U: PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin. Hypertension. 2005 Jul;46(1):137-43. Epub 2005 Jun 6.

Kinetic studies using the protein synthesis inhibitor cycloheximide showed that irbesartan prevented the cellular depletion of adiponectin protein.
To identify new antidiabetic mechanisms of ARBs, we studied the regulation of adiponectin by angiotensin II (Ang II) and different ARBs in murine 3T3-L1 adipocytes and obese Zucker rats.
3(0,0,0,3) Details
16933187 Ansurudeen I, Kopprasch S, Ehrhart-Bornstein M, Willenberg HS, Krug AW, Funk RH, Bornstein SR: Vascular-adrenal niche--endothelial cell-mediated sensitization of human adrenocortical cells to angiotensin II. Horm Metab Res. 2006 Jul;38(7):476-80.

The increase in aldosterone release after preincubation with endothelial cell-conditioned medium was sensitive to cycloheximide and KN-93.
2(0,0,0,2) Details
17064352 Bobrovskaya L, Gilligan C, Bolster EK, Flaherty JJ, Dickson PW, Dunkley PR: Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis. J Neurochem. 2007 Jan;100(2):479-89. Epub 2006 Oct 25.


Sustained phosphorylation and activation of TH were also observed with histamine and angiotensin II.
1(0,0,0,1) Details
15808886 Xu JW, Ikeda K, Kobayakawa A, Ikami T, Kayano Y, Mitani T, Yamori Y: Downregulation of Rac1 activation by caffeic acid in aortic smooth muscle cells. Life Sci. 2005 Apr 29;76(24):2861-72.

Our results showed that caffeic acid decrease Rac1 protein level under basal conditions and incubation with angiotensin II (ANG II) in vascular smooth muscle cells.
On the other hand, co-incubation with caffei caid and cycloheximide significantly accelerated the Rac1 degradation.
1(0,0,0,1) Details
19684181 McEwen ST, Balus SF, Durand MJ, Lombard JH: Angiotensin II maintains cerebral vascular relaxation via EGF receptor transactivation and ERK1/2. Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1296-303. Epub 2009 Aug 14.

The protective effect of ANG II infusion to restore vascular relaxation was eliminated by coinfusion of either the EGF receptor kinase inhibitor AG-1478 (20 microg/h), the ERK1/2 inhibitor PD-98059 (10 microg/h), or the protein synthesis inhibitor cycloheximide (5 microg/h).
1(0,0,0,1) Details