Name | CD4 |
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Synonyms | CD4; CD4 antigen (p55); CD4 molecule; CD4mut; T cell antigen T4/LEU3; T cell surface glycoprotein CD4; T cell surface antigen T4/Leu 3; T cell surface glycoprotein CD4 precursor… |
Name | cycloheximide |
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CAS |
PubMed | Abstract | RScore(About this table) | |
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16237056 | Park IK, Shultz LD, Letterio JJ, Gorham JD: TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1. J Immunol. 2005 Nov 1;175(9):5666-74. |
4(0,0,0,4) | Details |
16425129 | Sasson SC, Zaunders JJ, Zanetti G, King EM, Merlin KM, Smith DE, Stanley KK, Cooper DA, Kelleher AD: Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection. J Infect Dis. 2006 Feb 15;193(4):505-14. Epub 2006 Jan 17. The effects of IL-7 and cycloheximide on IL-7R expression by peripheral blood mononuclear cells were examined in vitro. Plasma IL-7 levels positively correlated with CD4 (+) T cell immune reconstitution in patients with PHI. |
3(0,0,0,3) | Details |
17182689 | Mangino G, Percario ZA, Fiorucci G, Vaccari G, Manrique S, Romeo G, Federico M, Geyer M, Affabris E: In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the release of beta interferon. J Virol. 2007 Mar;81(6):2777-91. Epub 2006 Dec 20. Nef regulates the cell surface expression of critical proteins (including down-regulation of CD4 and major histocompatibility complex class I), T-cell receptor signaling, and apoptosis, inducing proapoptotic effects in uninfected bystander cells and antiapoptotic effects in infected cells. Previously, we reported that Nef treatment of primary human monocyte-derived macrophages (MDMs) induces a cycloheximide-independent activation of NF-kappaB and the synthesis and secretion of a set of chemokines/cytokines that activate STAT1 and STAT3. |
1(0,0,0,1) | Details |
18718855 | Kondo K, Okuma K, Tanaka R, Matsuzaki G, Ansari AA, Tanaka Y: Rapid induction of OX40 ligand on primary T cells activated under DNA-damaging conditions. Hum Immunol. 2008 Sep;69(9):533-42. Epub 2008 Aug 15. Flow cytometric analyses demonstrated that a significant frequency of these DNA-damaged activated primary CD4+ and CD8+ T cells became OX40L+ as early as 1 hour after treatment. The OX40L induction on the DNA-damaged activated T cells was inhibited by treatment with either RNA or protein synthesis inhibitors, actinomycin D, or cycloheximide, respectively. |
1(0,0,0,1) | Details |
17164472 | Heo Y, Mondal TK, Gao D, Kasten-Jolly J, Kishikawa H, Lawrence DA: Posttranscriptional inhibition of interferon-gamma production by lead. Toxicol Sci. 2007 Mar;96(1):92-100. Epub 2006 Dec 12. Lead (Pb) is known to preferentially suppress the activation and development of type-1 CD4+ helper T cell (Th1) responses, whereas it enhances the development of type-2 CD4+ helper T cell (Th2) responses. Pb did not enhance protein degradation of IFNgamma, in that lactacystin, an effective blocker of proteosomal proteolysis, did not prevent loss of IFNgamma; additionally, Pb did not accelerate loss of IFNgamma after cycloheximide treatment. |
1(0,0,0,1) | Details |
19665696 | Oguma T, Ono T, Kajiwara T, Sato M, Miyahira Y, Arino H, Yoshihara Y, Tadakuma T: CD4 (+) CD8 (+) thymocytes are induced to cell death by a small dose of puromycin via ER stress. Cell Immunol. 2009;260(1):21-7. Epub 2009 Jul 14. The induction of apoptosis was blocked by the protein synthesis inhibitor cycloheximide, and to some extent by transfection of Bcl-xL or Bcl-2 genes. |
3(0,0,0,3) | Details |
16959949 | Verma-Gandhu M, Verdu EF, Cohen-Lyons D, Collins SM: Lymphocyte-mediated regulation of beta-endorphin in the myenteric plexus. Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G344-8. Epub 2006 Sep 7. Previously, we have shown that adoptive transfer of CD4+ T cells to severe combined immune-deficient (SCID) mice normalized immunodeficiency-related visceral hyperalgesia. However, exogenous beta-endorphin did upregulate beta-endorphin expression, and both cycloheximide and naloxone methiodide inhibited peptide upregulation. |
2(0,0,0,2) | Details |
18337562 | Murooka TT, Rahbar R, Platanias LC, Fish EN: CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1. Blood. 2008 May 15;111(10):4892-901. Epub 2008 Mar 12. Here, we examined the role for CCL5-mediated initiation of mRNA translation in CD4 (+) T-cell chemotaxis. Cycloheximide, but not actinomycin D, significantly reduced chemotaxis, suggesting a possible role for mRNA translation in T-cell migration. |
2(0,0,0,2) | Details |
19447459 | Mikulak J, Gianolini M, Versmisse P, Pancino G, Lusso P, Verani A: Biological and physical characterization of the X4 HIV-1 suppressive factor secreted by LPS-stimulated human macrophages. Virology. 2009 Jul 20;390(1):37-44. Epub 2009 May 17. LPS-stimulated macrophages release soluble factors that inhibit HIV-1 infection in both CD4 (+) T lymphocytes and macrophages. MDAF is sensitive to heat and proteinase K treatment, and it appears to be preformed within MDM, in that it is rapidly released upon LPS stimulation and its production is insensitive to cycloheximide, an inhibitor of protein neosynthesis. |
1(0,0,0,1) | Details |
16751404 | Kubota K: A novel functional T cell hybridoma recognizes macrophage cell death induced by bacteria: a possible role for innate lymphocytes in bacterial infection. J Immunol. 2006 Jun 15;176(12):7576-88. We have established a novel TCRalphabeta (TCRVbeta6)(+) CD4 (-) CD8 (-) T cell hybridoma designated B6HO3. Cycloheximide and Abs to H-2K (d), H-2D (d), Ia (d), CD1d, TCRVbeta6, and IL-12 did not inhibit the contact-dependent IFN-gamma response, indicating that this IFN-gamma response did not require de novo protein synthesis in bacterial-infected J774 cells and was TCR and IL-12 independent. |
1(0,0,0,1) | Details |
16777169 | Choudhary SK, Walker RM, Powell DM, Planelles V, Walsh C, Camerini D: CXCR4 tropic human immunodeficiency virus type 1 induces an apoptotic cascade in immature infected thymocytes that resembles thymocyte negative selection. Virology. 2006 Sep 1;352(2):268-84. Epub 2006 Jun 14. Moreover, X4-HIV-1 induced apoptosis primarily in immature CD4+ CD8+ (DP) thymocytes whereas most mature CD4 or CD8 single-positive (SP) thymocytes were resistant to X4 HIV-1-induced apoptosis despite infection. Furthermore, treatment of thymocytes with cycloheximide abrogated HIV-1-induced apoptosis, implying a requirement for de novo protein synthesis. |
1(0,0,0,1) | Details |