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Maruta T, Yanagita T, Matsuo K, Uezono Y, Satoh S, Nemoto T, Yoshikawa N, Kobayashi H, Takasaki M, Wada A: Lysophosphatidic acid-LPA1 receptor-Rho-Rho kinase-induced up-regulation of Nav1.7 sodium channel mRNA and protein in adrenal chromaffin cells: enhancement of 22Na+ influx, 45Ca2+ influx and catecholamine secretion. J Neurochem. 2008 Apr;105(2):401-12. Epub 2007 Nov 25.
LPA treatment (> or = 24 h) increased cell surface [3H] saxitoxin binding by approximately 28%, without altering the K (d) value; the increase was prevented by cycloheximide, actinomycin D, or Ki16425, dioctylglycerol pyrophosphate 8:0 (two inhibitors of LPA (1) and LPA3 receptors), or botulinum toxin C3 (Rho inhibitor), Y27632 (Rho kinase inhibitor), consistent with LPA (1) receptor expression in adrenal chromaffin cells. |
81(1,1,1,1) |
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