Protein Information

Name tyrosine hydroxylase
Synonyms Putative tyrosine hydroxylase variant; TH; TH protein; TYH; Truncated tyrosine hydroxylase; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyrosine hydroxylase…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
20184101 Alcaraz-Zubeldia M, Boll-Woehrlen MC, Montes-Lopez S, Perez-Severiano F, Martinez-Lazcano JC, Diaz-Ruiz A, Rios C: Copper sulfate prevents tyrosine hydroxylase reduced activity and motor deficits in a Parkinson's disease model in mice. Rev Invest Clin. 2009 Sep-Oct;61(5):405-11.
32(0,1,1,2) Details
16686 Schwarcz R, Coyle JT: Striatal lesions with kainic acid: neurochemical characteristics. Brain Res. 1977 May 27;127(2):235-49.

In contrast, the striatal content of dopamine and the synaptosomal uptake of dopamine were unchanged, and the activity of tyrosine hydroxylase was significantly increased.
In contrast to the effects of kainic acid, the injection of copper sulfate, a non-specific toxin, caused a proportionate reduction in the dopaminergic as well as the cholinergic and GABAergic presynaptic markers.
2(0,0,0,2) Details
19428787 Rubio-Osornio M, Montes S, Perez-Severiano F, Aguilera P, Floriano-Sanchez E, Monroy-Noyola A, Rubio C, Rios C: Copper reduces striatal protein nitration and tyrosine hydroxylase inactivation induced by MPP+ in rats. Neurochem Int. 2009 Jun;54(7):447-51. Epub 2009 Feb 6.

2(0,0,0,2) Details