| 16547004 |
Edlich F, Weiwad M, Wildemann D, Jarczowski F, Kilka S, Moutty MC, Jahreis G, Lucke C, Schmidt W, Striggow F, Fischer G: The specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl) cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia. J Biol Chem. 2006 May 26;281(21):14961-70. Epub 2006 Mar 17.
Here we show that neurotrophic FKBP ligands, such as GPI1046 and N-[methyl (ethoxycarbonyl)] cycloheximide, inhibit the calmodulin/Ca (2+) (CaM/Ca (2+))-regulated FKBP38 with up to 80-fold higher affinity than FKBP12. |
195(2,3,3,5) |
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