Protein Information

Name calcineurin (protein family or complex)
Synonyms Calcineurin; Calcineurins; Protein phosphatase 2B

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
17324936 Saeki M, Irie Y, Ni L, Itsuki Y, Terao Y, Kawabata S, Kamisaki Y: Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation. J Biol Chem. 2007 Apr 20;282(16):11786-94. Epub 2007 Feb 26.

Overexpression of calcineurin B in HEK293 cells potentiated processing of caspase-3 and apoptosis triggered by tumor necrosis factor-alpha and cycloheximide treatment.
36(0,1,1,6) Details
16458016 Canellada A, Cano E, Sanchez-Ruiloba L, Zafra F, Redondo JM: Calcium-dependent expression of TNF-alpha in neural cells is mediated by the calcineurin/NFAT pathway. Mol Cell Neurosci. 2006 Apr;31(4):692-701. Epub 2006 Feb 2.

4(0,0,0,4) Details
16000155 Kramer D, Caruso A, Nicoletti F, Genazzani AA: Somatostatin and the somatostatin receptor 2 are reciprocally controlled by calcineurin during cerebellar granule cell maturation. J Neurochem. 2005 Sep;94(5):1374-83. Epub 2005 Jul 5.

4(0,0,0,4) Details
15837527 Tenhunen O, Szokodi I, Ruskoaho H: Posttranscriptional activation of BNP gene expression in response to increased left ventricular wall stress: role of calcineurin and PKC. Regul Pept. 2005 Jun 30;128(3):187-96.

In contrast, the protein synthesis inhibitor cycloheximide increased baseline BNP mRNA levels and abolished the load-induced activation of gene expression.
Furthermore, we studied the effects of protein kinase C (PKC), calcineurin and protein phosphatase 2A (PP2A) inhibition to characterize the role of intracellular pathways in the stretch-induced gene expression in the left ventricle.
2(0,0,0,2) Details
17166486 Takadera T, Ohyashiki T: Caspase-dependent apoptosis induced by calcineurin inhibitors was prevented by glycogen synthase kinase-3 inhibitors in cultured rat cortical cells. Brain Res. 2007 Feb 16;1133(1):20-6. Epub 2006 Dec 12.

Calcineurin is selectively enriched within neurons of the central nervous system.
In addition, insulin growth factor-I (IGF-I) and cycloheximide completely blocked cell death.
1(0,0,0,1) Details
19244510 Li S, Zhang C, Takemori H, Zhou Y, Xiong ZQ: TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons. J Neurosci. 2009 Feb 25;29(8):2334-43.


Ca (2+) influx via voltage-gated calcium channels induced TORC1 dephosphorylation and translocation into the nucleus in a calcineurin-dependent manner.
1(0,0,0,1) Details