Protein Information

Name P46
Synonyms 46 kDa DNA polymerase delta interaction protein; DNA polymerase delta interacting protein 3; POLDIP 3; POLDIP3; Polymerase delta interacting protein 3; SKAR; p46…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
19151744 Liu HY, Wang ZM, Bai Y, Wang M, Li Y, Wei S, Zhou QH, Chen J: Different BAG-1 isoforms have distinct functions in modulating chemotherapeutic-induced apoptosis in breast cancer cells. Acta Pharmacol Sin. 2009 Feb;30(2):235-41. Epub 2009 Jan 19.

Furthermore, the cycloheximide chase assay indicated that the degradation of Bcl-2 protein was extended in the BAG-1 p50 and p46 transfected MCF-7 cells.
33(0,1,1,3) Details
18439101 Kato T, Noma H, Kitagawa M, Takahashi T, Oshitani N, Kitagawa S: Distinct role of c-Jun N-terminal kinase isoforms in human neutrophil apoptosis regulated by tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor. J Interferon Cytokine Res. 2008 Apr;28(4):235-43.

Stimulation of neutrophils with TNF-alpha and GM-CSF caused phosphorylation of p54 or p46 JNK or both.
TNF-alpha-induced JNK phosphorylation was sustained in the presence of cycloheximide, which was accompanied by accelerated neutrophil apoptosis.
2(0,0,0,2) Details