| Name | NHE3 |
|---|---|
| Synonyms | NHE 3; NHE3; Na(+)/H(+) exchanger 3; SLC9A3; Sodium/hydrogen exchanger 3; Solute carrier family 9 isoform A3; Solute carrier family 9 member 3; Na(+)/H(+) exchanger 3s… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16971495 | Wang D, Zhang H, Lang F, Yun CC: Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor. Am J Physiol Cell Physiol. 2007 Jan;292(1):C396-404. Epub 2006 Sep 13. Chronic regulation (24 h) of NHE3 was blocked completely by prevention of protein synthesis with cycloheximide or actinomycin D and by the glucocorticoid receptor blocker RU486. |
88(1,1,1,8) | Details |
| 16464174 | Malakooti J, Sandoval R, Amin MR, Clark J, Dudeja PK, Ramaswamy K: Transcriptional stimulation of the human NHE3 promoter activity by PMA: PKC independence and involvement of the transcription factor EGR-1. Biochem J. 2006 Jun 1;396(2):327-36. Pretreatment with actinomycin D or cycloheximide blocked the up-regulation of the NHE3 mRNA by PMA, indicating that the increased level of NHE3 mRNA expression is regulated by transcriptional activation and is dependent on de novo protein synthesis. 5'-Deletion of the promoter region and transfection analysis in C2BBe1 cells revealed that the PMA effect is mediated through a GC-rich DNA region between nt -88 and -69. |
86(1,1,1,6) | Details |
| 15942046 | Bobulescu IA, Dwarakanath V, Zou L, Zhang J, Baum M, Moe OW: Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosis. Am J Physiol Renal Physiol. 2005 Oct;289(4):F685-91. Epub 2005 Jun 7. NHE3 insertion (biotinylatable NHE3 after sulfo-NHS- blockade) was stimulated by dexamethasone incubation, with or without cycloheximide. |
37(0,1,1,7) | Details |
| 18404734 | Tattersall AL, Wilkins RJ: Modulation of Na+-H+ exchange isoforms NHE1 and NHE3 by insulin-like growth factor-1 in isolated bovine articular chondrocytes. J Orthop Res. 2008 Nov;26(11):1428-33. NHE3 activity was not detected in IGF-1-treated cells that had been incubated with the protein synthesis inhibitor cycloheximide, although NHE1 activity was unaffected. |
4(0,0,0,4) | Details |
| 16926447 | Lanaspa MA, Giral H, Breusegem SY, Halaihel N, Baile G, Catalan J, Carrodeguas JA, Barry NP, Levi M, Sorribas V: Interaction of MAP17 with NHERF3/4 induces translocation of the renal Na/Pi IIa transporter to the trans-Golgi. Am J Physiol Renal Physiol. 2007 Jan;292(1):F230-42. Epub 2006 Aug 22. Several PDZ domain-containing proteins, including the four NHERF proteins, as well as NaPiIIa and NHE3, were found to bind to MAP17. |
1(0,0,0,1) | Details |