| Name | fibronectin |
|---|---|
| Synonyms | CIG; MSF; Cold insoluble globulin; FINC; FN; FN1; Fibronectin; Fibronectin 1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15652337 | Peters DM, Herbert K, Biddick B, Peterson JA: Myocilin binding to Hep II domain of fibronectin inhibits cell spreading and incorporation of paxillin into focal adhesions. Exp Cell Res. 2005 Feb 15;303(2):218-28. Epub 2004 Nov 2. Using myocilin produced in sf9 insect cells, myocilin inhibited spreading of cycloheximide-treated human skin fibroblasts plated on substrates co-coated with myocilin and either fibronectin or its II domain. |
33(0,1,1,3) | Details |
| 18359077 | Lord MS, Modin C, Foss M, Duch M, Simmons A, Pedersen FS, Besenbacher F, Milthorpe BK: Extracellular matrix remodelling during cell adhesion monitored by the quartz crystal microbalance. Biomaterials. 2008 Jun;29(17):2581-7. Epub 2008 Mar 21. The QCM-D was able to detect differences in the untreated cellular responses to fibronectin versus serum precoated Ta and PS (ox) substrates, while cycloheximide treatment of the cells produced the same QCM-D response for fibronectin and serum precoatings on each of the materials. |
32(0,1,1,2) | Details |
| 16180102 | Jiang Y, Cheng DW, Crook ED, Singh LP: Transforming growth factor-beta1 regulation of laminin gamma1 and fibronectin expression and survival of mouse mesangial cells. Mol Cell Biochem. 2005 Oct;278(1-2):165-75. |
4(0,0,0,4) | Details |
| 19245706 | Peterson AW, Halter M, Tona A, Bhadriraju K, Plant AL: Surface plasmon resonance imaging of cells and surface-associated fibronectin. BMC Cell Biol. 2009 Feb 26;10:16. |
2(0,0,0,2) | Details |
| 16817231 | Siri S, Chen MJ, Chen TT: Biological activity of rainbow trout Ea4-peptide of the pro-insulin-like growth factor (pro-IGF)-I on promoting attachment of breast cancer cells (MDA-MB-231) via alpha2- and beta1-integrin. J Cell Biochem. 2006 Dec 15;99(6):1524-35. In addition, rtEa4-peptide induced the expression of fibronectin 1 and laminin receptor genes in MDA-MB-231 cells. Blocking new protein synthesis by cycloheximide significantly reduced the attachment of MDA-MB-231 cells to rtEa4-peptide coated wells by 50%. |
4(0,0,0,4) | Details |
| 16669788 | Bhattacharya S, Ray RM, Johnson LR: Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. Biochem J. 2006 Aug 1;397(3):437-47. Cells plated on fibronectin had significantly higher beta3 phosphorylation and Src activation compared with plastic. Arg-Gly-Asp-Ser inhibited beta3, Src and Akt phosphorylation and sensitized polyamine-depleted cells to tumour necrosis factor alpha/cycloheximide-mediated apoptosis. |
3(0,0,0,3) | Details |
| 15735708 | Rodrigue CM, Porteu F, Navarro N, Bruyneel E, Bracke M, Romeo PH, Gespach C, Garel MC: The cancer chemopreventive agent induces tensin, a cell-matrix adhesion protein with signaling and antitumor activities. Oncogene. 2005 May 5;24(20):3274-84. Tensin induction by RV is associated with increased K562 cell adhesion to fibronectin, cell spreading and actin polymerization. |
2(0,0,0,2) | Details |
| 16236823 | Vainionpaa N, Kikkawa Y, Lounatmaa K, Miner JH, Rousselle P, Virtanen I: Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells. Am J Physiol Cell Physiol. 2006 Mar;290(3):C764-75. Epub 2005 Oct 19. Field emission scanning electron microscopy and immunohistochemistry showed that the endothelial cells spread on laminin-10 and formed fibronectin-positive fibrillar adhesion structures. When the protein synthesis during the adhesion was inhibited with cycloheximide, the formation of fibrillar adhesions on laminin-10 was abolished, suggesting that laminin-10 does not stimulate the formation of any adhesion structures. |
2(0,0,0,2) | Details |
| 15525600 | Lin KH, Chen CY, Chen SL, Yen CC, Huang YH, Shih CH, Shen JJ, Yang RC, Wang CS: Regulation of fibronectin by thyroid hormone receptors. . J Mol Endocrinol. 2004 Oct;33(2):445-58. Blockade of protein synthesis by cycloheximide almost completely inhibited the concomitant induction of FN mRNA by T3, indicating that T3 indirectly regulates FN. |
2(0,0,0,2) | Details |
| 18935790 | Huang YH, Tsai MM, Lin KH: Thyroid hormone dependent regulation of target genes and their physiological significance. Chang Gung Med J. 2008 Jul-Aug;31(4):325-34. The data demonstrated that approximately 149 genes represented were positively regulated by T3, including fibrinogen, transferrin, fibronectin (FN), androgen receptor (AR)-associated protein (ARA70), and dehydroepiandrosterone sulfotransferase family 1A member 2 (SULT2A1). The protein synthesis inhibitor, cycloheximide was used to determine whether the regulation was direct or indirect. |
1(0,0,0,1) | Details |
| 17825525 | Ray RM, Bhattacharya S, Johnson LR: EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells. Cell Signal. 2007 Dec;19(12):2519-27. Epub 2007 Aug 15. Fibronectin activated the EGFR, Src, ERKs and protected cells from apoptosis. |
1(0,0,0,1) | Details |
| 20091742 | Chiang TA, Yang YL, Yang YY, Hu MH, Wu PF, Liu SF, Huang RM, Liao TN, Hung CY, Hung TJ, Lee TC: Hyperosmolarity enhanced susceptibility to renal tubular fibrosis by modulating catabolism of type I transforming growth factor-beta receptors. J Cell Biochem. 2010 Mar 1;109(4):663-71. In addition, through the use of cycloheximide and the proteasome inhibitor MG132, we showed that hyperosmolarity significantly increased the half-life and inhibited the protein level of TGF-beta RI by polyubiquitination and proteasomal degradation. We show that hyperosmolarity significantly enhances the susceptibility to exogenous transforming growth factor (TGF)-beta1, as (27.5 mM) significantly enhanced the TGF-beta1-induced increase in fibronectin levels compared with control experiments (5.5 mM). |
1(0,0,0,1) | Details |
| 15684830 | Suon S, Jin H, Donaldson AE, Caterson EJ, Tuan RS, Deschennes G, Marshall C, Iacovitti L: Transient differentiation of adult human bone marrow cells into neuron-like cells in culture: development of morphological and biochemical traits is mediated by different molecular mechanisms. Stem Cells Dev. 2004 Dec;13(6):625-35. In contrast, the mesenchymal marker, fibronectin, which is highly expressed in the undifferentiated state, is reduced following differentiation. These biochemical changes, but not the acquisition of a neuron-like appearance, are partially inhibited by incubation of hMSCs with protein (cycloheximide) and mRNA (actinomycin D) synthesis inhibitors with differentiating reagents. |
1(0,0,0,1) | Details |
| 15535971 | Kamiya S, Kawaguchi T, Hasebe S, Kamiya N, Saito Y, Miura S, Wada S, Yajima H, Katayama T, Fukai F: A fibronectin fragment induces tumor necrosis factor production of rat basophilic leukemia cells. Biochim Biophys Acta. 2004 Nov 18;1675(1-3):87-94. The TNF-alpha secretion was abrogated by treatment of RBL-2H3 cells with cycloheximide, indicating the de novo synthesis of TNF-alpha, but not with polymyxin B, excluding the possible TNF-alpha induction by some contaminated lipopolysaccharides. |
1(0,0,0,1) | Details |
| 19718660 | Ranzato E, Grosso S, Patrone M, Betta PG, Viarengo A, Biffo S: Spreading of mesothelioma cells is rapamycin-sensitive and requires continuing translation. J Cell Biochem. 2009 Nov 1;108(4):867-76. Specifically, we found that sarcomatous cells produce high amounts of fibronectin, able to support the spreading of mesothelioma cells. Spreading of cancer cells on fibronectin does not require de novo transcription but is sensitive to cycloheximide, an inhibitor of protein synthesis. |
1(0,0,0,1) | Details |