| Name | E2F1 |
|---|---|
| Synonyms | E2F transcription factor 1; RBP 3; RBP3; E2F 1; E2F1; PBR 3; PBR3; PRB binding protein E2F1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17482685 | Nowak K, Killmer K, Gessner C, Lutz W: E2F-1 regulates expression of FOXO1 and FOXO3a. . Biochim Biophys Acta. 2007 Apr;1769(4):244-52. Epub 2007 Apr 6. Indeed, a 4-hydroxytamoxifen activated E2F-1-ER fusion protein induced FOXO expression in the presence of cycloheximide. |
37(0,1,1,7) | Details |
| 17173074 | Ma Y, Cress WD: Transcriptional upregulation of p57 (Kip2) by the cyclin-dependent kinase inhibitor BMS-387032 is E2F dependent and serves as a negative feedback loop limiting cytotoxicity. Oncogene. 2007 May 24;26(24):3532-40. Epub 2006 Dec 18. An E2F1-estrogen receptor fusion protein activated the endogenous p57 promoter in response to hydroxytamoxifen treatment in the presence of cycloheximide. |
33(0,1,1,3) | Details |
| 15869948 | Strachan GD, Kopp AS, Koike MA, Morgan KL, Jordan-Sciutto KL: Chemokine- and neurotrophic factor-induced changes in E2F1 localization and phosphorylation of the retinoblastoma susceptibility gene product (pRb) occur by distinct mechanisms in murine cortical cultures. Exp Neurol. 2005 Jun;193(2):455-68. |
7(0,0,0,7) | Details |
| 18606816 | Wang WH, Hullinger RL, Andrisani OM: Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis. J Biol Chem. 2008 Sep 12;283(37):25455-67. Epub 2008 Jul 7. |
4(0,0,0,4) | Details |
| 20123965 | Wade HE, Kobayashi S, Eaton ML, Jansen MS, Lobenhofer EK, Lupien M, Geistlinger TR, Zhu W, Nevins JR, Brown M, Otteson DC, McDonnell DP: Multimodal regulation of E2F1 gene expression by progestins. . Mol Cell Biol. 2010 Apr;30(8):1866-77. Epub 2010 Feb 1. However, we also noted that cycloheximide partially inhibits R5020 induction of E2F1 expression, indicating that the ligand-dependent actions of PR on this gene may involve additional indirect regulatory pathways. |
86(1,1,1,6) | Details |
| 18039672 | Freeman SN, Ma Y, Cress WD: RhoBTB2 (DBC2) is a mitotic E2F1 target gene with a novel role in apoptosis. J Biol Chem. 2008 Jan 25;283(4):2353-62. Epub 2007 Nov 26. This also occurred during the induction of E2F1 activity in the presence of cycloheximide, thus indicating that RhoBTB2 is a direct target. |
39(0,1,1,9) | Details |
| 15897325 | Li Z, Stanelle J, Leurs C, Hanenberg H, Putzer BM: Selection of novel mediators of E2F1-induced apoptosis through retroviral expression of an antisense cDNA library. Nucleic Acids Res. 2005 May 16;33(9):2813-21. Print 2005. Four genes showed an increase in expression intensity in the presence of cycloheximide, suggesting a direct effect of E2F1 on gene transcription, whereas one gene was identified as an indirect target. |
39(0,1,1,9) | Details |