Protein Information

Name Eotaxins
Synonyms CCL11; Chemokine CC motif ligand 11; Eosinophil chemotactic protein; Eotaxin; Eotaxin precursor; SCYA11; Small inducible cytokine A11; chemokine (C C motif) ligand 11…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
16951370 Rahman MS, Yamasaki A, Yang J, Shan L, Halayko AJ, Gounni AS: IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells: role of MAPK (Erk1/2, JNK, and p38) pathways. J Immunol. 2006 Sep 15;177(6):4064-71.

Moreover, IL-17A significantly induced eotaxin-1/CCL11 release and mRNA expression, an effect that was abrogated with cycloheximide and actinomycin D treatment.
13(0,0,1,8) Details
19799897 Fritz DK, Kerr C, Botelho F, Stampfli M, Richards CD: Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: regulation of the type-II IL-4 receptor chains IL-4Ralpha and IL-13Ralpha1. Exp Cell Res. 2009 Dec 10;315(20):3486-99. Epub 2009 Sep 30.

6(0,0,0,6) Details
15863444 Abonyo BO, Alexander MS, Heiman AS: Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L478-88. Epub 2005 Apr 29.

Eotaxins (CCL11, CCL24, CCL26) originating from airway epithelial cells and leukocytes have been detected in bronchoalveolar lavage of asthmatics.
Cycloheximide and actinomycin D abrogated IL-4- and IL-13-dependent CCL26 but not CCL24 secretion.
4(0,0,0,4) Details