Protein Information

Name Resistin
Synonyms ADSF; Adipose tissue specific secretory factor; C/EBP epsilon regulated myeloid specific secreted cysteine rich protein; Cysteine rich secreted protein A12 alpha like 2; Cysteine rich secreted protein FIZZ3; FIZZ 3; FIZZ3; HXCP 1…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
18417718 Lee MJ, Lin H, Liu CW, Wu MH, Liao WJ, Chang HH, Ku HC, Chien YS, Ding WH, Kao YH: Octylphenol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor and extracellular signal-regulated kinase pathways. Am J Physiol Cell Physiol. 2008 Jun;294(6):C1542-51. Epub 2008 Apr 16.

The basal half-life of resistin protein induced by cycloheximide was lengthened by octylphenol treatment, suggesting that octylphenol decreases the rate of resistin protein degradation.
41(0,1,1,11) Details
16876120 Chung SS, Choi HH, Cho YM, Lee HK, Park KS: Sp1 mediates repression of the resistin gene by PPARgamma agonists in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2006 Sep 15;348(1):253-8. Epub 2006 Jul 18.

Resistin gene expression was decreased by TZD in fully differentiated 3T3-L1 adipocytes, which was abolished after treatment of cycloheximide (a protein synthesis inhibitor).
37(0,1,1,7) Details
16740979 Chen YH, Lee MJ, Chang HH, Hung PF, Kao YH: 17 beta-estradiol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor, extracellularly regulated kinase, and CCAAT/enhancer binding protein-alpha pathways. Endocrinology. 2006 Sep;147(9):4496-504. Epub 2006 Jun 1.

Treatment with either actinomycin D or cycloheximide prevented E2-stimulated resistin mRNA expression, suggesting that the effect of E2 requires new mRNA and protein synthesis.
13(0,0,1,8) Details
15585589 Chen YH, Hung PF, Kao YH: IGF-I downregulates resistin gene expression and protein secretion. . Am J Physiol Endocrinol Metab. 2005 May;288(5):E1019-27. Epub 2004 Dec 7.

Treatment with cycloheximide, but not with actinomycin D, prevented IGF-I-suppressed Rstn mRNA expression, suggesting that IGF-I destabilizes Rstn mRNA and that IGF-I's effect requires new protein, but not mRNA, synthesis.
2(0,0,0,2) Details
16159906 Liu HS, Chen YH, Hung PF, Kao YH: Inhibitory effect of green tea (-)-epigallocatechin gallate on resistin gene expression in 3T3-L1 adipocytes depends on the ERK pathway. Am J Physiol Endocrinol Metab. 2006 Feb;290(2):E273-81. Epub 2005 Sep 13.

Treatment with cycloheximide did not prevent EGCG-suppressed Rstn mRNA levels, which suggests that the effect of EGCG does not require new protein synthesis.
2(0,0,0,2) Details