Protein Information

Name albumin
Synonyms ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
15547677 Ishida K, Yamaguchi M: Role of albumin in osteoblastic cells: enhancement of cell proliferation and suppression of alkaline phosphatase activity. Int J Mol Med. 2004 Dec;14(6):1077-81.

Also, the stimulating effect of albumin on cell proliferation was completely prevented in the presence of cycloheximide (10 (-7) M), an inhibitor of protein synthesis, or 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), an inhibitor of transcriptional activity.
39(0,1,1,9) Details
18053095 Botos E, Klumperman J, Oorschot V, Igyarto B, Magyar A, Olah M, Kiss AL: Caveolin-1 is transported to multi-vesicular bodies after albumin-induced endocytosis of caveolae in HepG2 cells. J Cell Mol Med. 2008 Sep-Oct;12(5A):1632-9. Epub 2007 Dec 5.

This increase was blocked by cycloheximide treatment, indicating that albumin internalization also stimulates de novo protein synthesis, which is necessary for new caveolae formation.
37(0,1,1,7) Details
16313754 Wang XY, Li WQ, Lu J, Li N, Li JS: [Mechanism of reduction of albumin expression induced by lipopolysaccharide in rat hepatocytes]. Chin Med J. 2005 Oct 20;118(20):1695-702.

In another group, hepatocytes were pretreated with 100, 40 or 20 micromol/L of cycloheximide (CHX, an inhibitor of protein synthesis) for 30 minutes followed by 1 microg/ml LPS for 24 hours.
7(0,0,0,7) Details
16125561 Laowtammathron C, Lorthongpanich C, Ketudat-Cairns M, Hochi S, Parnpai R: Factors affecting cryosurvival of nuclear-transferred bovine and swamp buffalo blastocysts: effects of hatching stage, linoleic acid-albumin in IVC medium and Ficoll supplementation to vitrification solution. Theriogenology. 2005 Sep 15;64(5):1185-96.

Fused couplets were activated with ethanol and cycloheximide-cytochalasin D (day 0), and were allowed to develop in the presence of 0.3% BSA or 0.1% LAA+0.2% BSA.
2(0,0,0,2) Details
18359077 Lord MS, Modin C, Foss M, Duch M, Simmons A, Pedersen FS, Besenbacher F, Milthorpe BK: Extracellular matrix remodelling during cell adhesion monitored by the quartz crystal microbalance. Biomaterials. 2008 Jun;29(17):2581-7. Epub 2008 Mar 21.

The adhesion of NIH3T3 (EGFP) fibroblasts to serum protein (albumin or fibronectin) precoated tantalum (Ta) and oxidised polystyrene (PS (ox)) surfaces was examined using the quartz crystal microbalance with dissipation (QCM-D) monitoring and fluorescence microscopy.
The cells were either untreated or treated with cycloheximide to examine the contribution of endogenous protein production during cell adhesion to the QCM-D response over a period of 2h.
1(0,0,0,1) Details
16289172 Arima S: Aldosterone and the kidney: rapid regulation of renal microcirculation. Steroids. 2006 Apr;71(4):281-5. Epub 2005 Nov 9.


This notion was further supported by the finding that neither actinomycin D nor cycloheximide had effect.
0(0,0,0,0) Details