| Name | caspases (protein family or complex) |
|---|---|
| Synonyms | caspase; caspases |
| Name | copper sulfate |
|---|---|
| CAS | sulfuric acid copper(2+) salt (1:1) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10891353 | Vicca S, Hennequin C, Nguyen-Khoa T, Massy ZA, Descamps-Latscha B, Drueke TB, Lacour B: Caspase-dependent apoptosis in THP-1 cells exposed to oxidized low-density lipoproteins. Biochem Biophys Res Commun. 2000 Jul 14;273(3):948-54. We investigated the apoptotic process in human monocytic THP-1 cell line, exposed to oxLDL generated by treatment of native LDL either with hypochlorous acid (HOCl), mainly affecting the protein moiety, or with copper sulfate (CuSO (4)), mainly affecting the lipid moiety. |
2(0,0,0,2) | Details |
| 17239413 | Chen TG, Chen TL, Chang HC, Tai YT, Cherng YG, Chang YT, Chen RM: Oxidized low-density lipoprotein induces apoptotic insults to mouse cerebral endothelial cells via a Bax-mitochondria-caspase protease pathway. Toxicol Appl Pharmacol. 2007 Feb 15;219(1):42-53. Epub 2006 Dec 6. Mouse CECs were isolated from brain tissues and identified by immunocytochemical staining of vimentin and Factor VIII. oxLDL was prepared from LDL oxidation by copper sulfate. |
2(0,0,0,2) | Details |
| 17584059 | Sorenson JR, Wangila GW: Co-treatment with compounds dramatically decreases toxicities observed with cisplatin cancer therapy and the anticancer efficacy of some chelates supports the conclusion that chelate therapy may be markedly more effective and less toxic than cisplatin therapy. Curr Med Chem. 2007;14(14):1499-503. Initially it was found that copper sulfate treatment completely prevented lethality as well as gastric and nephrotoxicity without compromising Pt (II) (NH3) 2 (CL) 2 antineoplastic activity, which led to suggestions that prior Cu (II)-treatment be used clinically to prevent serious side effects of Pt (II) (NH3) 2 (CL) 2-treatment. Another stable non-toxic and non-polar lipophilic chelate, (II) 2 (3,5-ditertiarybutylsalicylate) 4, was found to prevent Bax-initiated and caspases-3-activation mediated apoptosis. |
1(0,0,0,1) | Details |
| 18037448 | Miike T, Shirahase H, Jino H, Kunishiro K, Kanda M, Kurahashi K: Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and accumulation under oxidative stress in THP-1 cell-derived foam cells. Life Sci. 2008 Jan 2;82(1-2):79-84. Epub 2007 Nov 26. The foam cells showed caspase-dependent apoptotic changes on exposure to oxidative stress for 6 h, and necrotic changes with the leakage of LDH after 24 h. |
1(0,0,0,1) | Details |