| Name | MAPK (protein family or complex) |
|---|---|
| Synonyms | MAPK; mitogen activated protein kinase; mitogen activated protein kinases |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19778406 | Ding HD, Zhang XH, Xu SC, Sun LL, Jiang MY, Zhang AY, Jin YG: Induction of protection against paraquat-induced oxidative damage by abscisic acid in maize leaves is mediated through mitogen-activated protein kinase. J Integr Plant Biol. 2009 Oct;51(10):961-72. |
91(1,1,2,6) | Details |
| 17324951 | Klintworth H, Newhouse K, Li T, Choi WS, Faigle R, Xia Z: Activation of c-Jun N-terminal protein kinase is a common mechanism underlying paraquat- and rotenone-induced dopaminergic cell apoptosis. Toxicol Sci. 2007 May;97(1):149-62. Epub 2007 Feb 25. The selective ability of paraquat and rotenone to induce apoptosis in different cell lines correlates with their ability to activate c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein kinases. |
31(0,1,1,1) | Details |
| 18502748 | Fernandes AF, Zhou J, Zhang X, Bian Q, Sparrow J, Taylor A, Pereira P, Shang F: Oxidative inactivation of the proteasome in retinal pigment epithelial cells. J Biol Chem. 2008 Jul 25;283(30):20745-53. Epub 2008 May 23. The downstream signaling pathways that govern the production of IL-8 include NF-kappaB and p38 MAPK. We found that exposure of RPE cells to H (2) O (2), paraquat, or A2E-mediated photooxidation resulted in increased expression and secretion of IL-8. |
3(0,0,0,3) | Details |
| 15618434 | Tsukamoto S, Morita S, Hirano E, Yokoi H, Masumura T, Tanaka K: A novel cis-element that is responsive to oxidative stress regulates three antioxidant defense genes in rice. Plant Physiol. 2005 Jan;137(1):317-27. Epub 2004 Dec 23. Application of the mitogen-activated protein kinase kinase inhibitor caused the constitutive induction of the sodCc1, trxh, and grx genes and the activation of CORE without methyl viologen treatment. |
2(0,0,0,2) | Details |
| 18373731 | Minelli A, Conte C, Grottelli S, Bellezza M, Cacciatore I, Bolanos JP: Cyclo (His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence. J Cell Mol Med. 2009 Jun;13(6):1149-61. Epub 2008 Mar 29. Cyclo (His-Pro) attenuated reactive species production, and prevented depletion caused by rotenone, paraquat and beta-amyloid treatment. Finally, pharmacological inhibition of p-38 MAPK partially prevented both cyclo (His-Pro)-mediated Nrf2 activation and cellular protection. |
2(0,0,0,2) | Details |
| 11577197 | Yuasa T, Ichimura K, Mizoguchi T, Shinozaki K: Oxidative stress activates ATMPK6, an Arabidopsis homologue of MAP kinase. . Plant Cell Physiol. 2001 Sep;42(9):1012-6. Mitogen-activated protein kinase (MAPK) cascades function in biotic and abiotic stress responses in plants. In leaves, ATMPK6 was activated by paraquat and 3-amino-1,2,4-triazole (a catalase inhibitor). |
2(0,0,0,2) | Details |
| 10970895 | Asoh S, Ohtsu T, Ohta S: The super anti-apoptotic factor Bcl-xFNK constructed by disturbing intramolecular polar interactions in rat Bcl-xL. J Biol Chem. 2000 Nov 24;275(47):37240-5. Bcl-xFNK might gain a new function to activate the mitogen-activated protein kinase in a cell-type specific manner. When overexpressed in Jurkat cells, Bcl-xFNK was markedly more potent in prolonging survival following apoptosis-inducing treatment with a kind of cell death cytokines (anti-Fas), a protein kinase inhibitor (staurosporine), cell cycle inhibitors (TN-16, camptothecin, hydroxyurea, and trichostatin A), or oxidative stress peroxide and paraquat) than wild-type Bcl-x (L). |
1(0,0,0,1) | Details |
| 16729024 | Salinas LS, Maldonado E, Navarro RE: Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans. Cell Death Differ. 2006 Dec;13(12):2129-39. Epub 2006 May 26. We also learned that the MAPK kinases MEK-1 and SEK-1, and the p53 antagonist protein ABL-1, are essential for stress-induced germ cell apoptosis. |
1(0,0,0,1) | Details |
| 16919916 | Mitra S, Abraham E: Participation of in neutrophil activation and cytokine production. Biochim Biophys Acta. 2006 Aug;1762(8):732-41. Epub 2006 Jul 8. These results demonstrate that increased intracellular concentrations are proinflammatory in neutrophils, acting through a p38 MAPK dependent mechanism that results in enhanced nuclear accumulation of NF-kappaB and increased expression of NF-kappaB dependent proinflammatory cytokines. To examine the role of in neutrophil activation, we exposed resting neutrophils and neutrophils stimulated with LPS to paraquat, an agent that specifically increases intracellular concentrations. |
1(0,0,0,1) | Details |
| 17018646 | Ramachandiran S, Hansen JM, Jones DP, Richardson JR, Miller GW: Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation. Toxicol Sci. 2007 Jan;95(1):163-71. Epub 2006 Oct 3. |
0(0,0,0,0) | Details |