Protein Information

Name Organic cation transporters
Synonyms HOCT 1; OCT1; HOCT1; Oct1_cds; Organic cation transporter; Organic cation transporter 1; SLC22A1; Solute carrier family 22 member 1…

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
17495125 Chen Y, Zhang S, Sorani M, Giacomini KM: Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. J Pharmacol Exp Ther. 2007 Aug;322(2):695-700. Epub 2007 May 10.
32(0,1,1,2) Details
19357179 Lee WK, Reichold M, Edemir B, Ciarimboli G, Warth R, Koepsell H, Thevenod F: Organic cation transporters OCT1, 2, and 3 mediate high-affinity transport of the mutagenic vital dye ethidium in the kidney proximal tubule. Am J Physiol Renal Physiol. 2009 Jun;296(6):F1504-13. Epub 2009 Apr 8.

2(0,0,0,2) Details
19702534 Lee WK, Wolff NA, Thevenod F: Organic cation transporters: physiology, toxicology and special focus on ethidium as a novel substrate. Curr Drug Metab. 2009 Jul;10(6):617-31. Epub 2009 Jul 15.

Importantly, besides a wide range of clinically used drugs, these also include several toxins like the neurotoxin 1-methyl-4-phenylpyridinium (MPP (+)) and herbicide paraquat.
2(0,0,0,2) Details