| Name | thioredoxin reductase |
|---|---|
| Synonyms | ACR 1; PLP; ACR1; AOEB166; Alu corepressor 1; Antioxidant enzyme B166; B166; Liver tissue 2D page spot 71B… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20345759 | Sun HN, Kim SU, Huang SM, Kim JM, Park YH, Kim SH, Yang HY, Chung KJ, Lee TH, Choi HS, Min JS, Park MK, Kim SK, Lee SR, Chang KT, Lee SH, Yu DY, Lee DS: Microglial peroxiredoxin V acts as an inducible anti-inflammatory antioxidant through cooperation with redox signaling cascades. J Neurochem. 2010 Mar 20. Unlike in stimulation of oxidative insults with paraquat and peroxide, Prx V expression is highly sensitive to LPS-stimulation in microglia. |
9(0,0,1,4) | Details |
| 19128239 | Radyuk SN, Michalak K, Klichko VI, Benes J, Rebrin I, Sohal RS, Orr WC: Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila. Biochem J. 2009 Apr 15;419(2):437-45. TUNEL (terminal deoxynucleotidyl transferase-mediated nick-end labelling) analysis revealed that the dprx5 (-/-) null mutant had discernible tissue-specific apoptotic patterns, similar to those observed in control flies exposed to paraquat. |
5(0,0,0,5) | Details |
| 12715897 | Missirlis F, Rahlfs S, Dimopoulos N, Bauer H, Becker K, Hilliker A, Phillips JP, Jackle H: A putative peroxidase of Drosophila encodes a thioredoxin peroxidase that provides resistance against oxidative stress but fails to complement a lack of catalase activity. Biol Chem. 2003 Mar;384(3):463-72. Cellular defense systems against reactive species (ROS) include thioredoxin reductase (TrxR) and glutathione reductase (GR). |
1(0,0,0,1) | Details |
| 11673642 | Zhang JS, Gao XY, Zhang LD, Bao YP: Biological effects of a nano red elemental . Biofactors. 2001;15(1):27-38. Nano-Se and selenite are similarly cell growth inhibited and stimulated synthesis of peroxidase (GPx), phospholipid hydroperoxide peroxidase (PHGPx) and thioredoxin reductase (TR). |
1(0,0,0,1) | Details |
| 16328792 | Keryer E, Collin V, Lavergne D, Lemaire S, Issakidis-Bourguet E: Characterization of Arabidopsis Mutants for the Variable Subunit of Ferredoxin:thioredoxin Reductase. Photosynth Res. 2004;79(3):265-74. The ferredoxin/thioredoxin reductase (FTR) is the key enzyme of a light dependent redox regulatory system controlling enzyme activities in oxygenic photosynthetic cells. Disruptants were found significantly more sensitive to oxidative stress as imposed under high light or in the presence of paraquat. |
1(0,0,0,1) | Details |
| 12663510 | Zhang J, Svehlikova V, Bao Y, Howie AF, Beckett GJ, Williamson G: Synergy between and in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis. 2003 Mar;24(3):497-503. Thioredoxin reductases (TrxRs) catalyse the -dependent reduction of thioredoxin and play an important role in multiple cellular events related to carcinogenesis including cell proliferation, apoptosis and cell signaling. The combination of and Se also efficiently protected HepG2 cells from paraquat-induced cell death, whereas -only and Se-only treatments showed very little if any protective effect. |
1(0,0,0,1) | Details |
| 15618175 | Wang G, Olczak AA, Walton JP, Maier RJ: Contribution of the Helicobacter pylori thiol peroxidase bacterioferritin comigratory protein to oxidative stress resistance and host colonization. Infect Immun. 2005 Jan;73(1):378-84. Compared to the parent strain and the ahpC mutant strain, the bcp mutant showed moderate sensitivity to the -generating agent paraquat and to organic hydroperoxides. Purified BCP was shown to be a thiol peroxidase that depends on the reducing activity of thioredoxin and thioredoxin reductase. |
1(0,0,0,1) | Details |
| 17055214 | Takizawa M, Komori K, Tampo Y, Yonaha M: Paraquat-induced oxidative stress and dysfunction of cellular redox systems including antioxidative defense enzymes peroxidase and thioredoxin reductase. Toxicol In Vitro. 2007 Apr;21(3):355-63. Epub 2006 Sep 14. Taken together, the results suggest that the reduced regenerative ability of oxidatively damaged proteins including GAPDH due to the inactivation of thioredoxin reductase and peroxidase by paraquat may contribute to increasing oxidative stress, leading to cell death. |
125(1,2,4,5) | Details |
| 12782306 | Tien Nguyen-nhu N, Knoops B: Mitochondrial and cytosolic expression of human peroxiredoxin 5 in Saccharomyces cerevisiae protect yeast cells from oxidative stress induced by paraquat. FEBS Lett. 2003 Jun 5;544(1-3):148-52. |
19(0,0,3,4) | Details |
| 17229725 | Gray JP, Heck DE, Mishin V, Smith PJ, Hong JY, Thiruchelvam M, Cory-Slechta DA, Laskin DL, Laskin JD: Paraquat increases -insensitive respiration in murine lung epithelial cells by activating an NAD (P) H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase. J Biol Chem. 2007 Mar 16;282(11):7939-49. Epub 2007 Jan 17. |
13(0,0,2,3) | Details |