Name | ER alpha |
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Synonyms | ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA… |
Name | paraquat |
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CAS | 1,1′-dimethyl-4,4′-bipyridinium |
PubMed | Abstract | RScore(About this table) | |
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16970245 | Huang CF, Wang YR, Yen CH, Chou SH, Lau YT: Paraquat-induced lipid peroxidation: effects of ovariectomy and estrogen receptor antagonist. Chin J Physiol. 2006 Jun 30;49(3):141-6. |
32(0,1,1,2) | Details |
20128815 | Manthey D, Gamerdinger M, Behl C: The selective beta (1)-adrenoceptor antagonist nebivolol is a potential oestrogen receptor agonist with neuroprotective abilities. Br J Pharmacol. 2010 Feb 1. Experimental approach: Human neuroepithelioma SK-N-MC cells stably transfected with human ER alpha and beta, and mouse N2A neuroblastoma cells expressing human APP695 (SWE)[N2Aswe, stably transfected with the Swedish mutation form of the Alzheimer-associated amyloid precursor protein (APPswe, K670M/N671L)] were incubated with different concentrations of nebivolol and 17beta- (E2) for 24-48 h. Furthermore, cell survival rates were determined, and oxidative stress was induced by peroxide and paraquat. |
1(0,0,0,1) | Details |
15325966 | Gelinas S, Bureau G, Valastro B, Massicotte G, Cicchetti F, Chiasson K, Gagne B, Blanchet J, Martinoli MG: Alpha and paraquat-induced oxidative stress. Neurotox Res. 2004;6(2):141-8. Paraquat also decreases estrogen receptor alpha in neuronal PC12 cells, thus suggesting new routes for paraquat to collapse cellular metabolism. |
protect neuronal but not native PC12 cells from 31(0,1,1,1) | Details |