Protein Information

Name ER alpha
Synonyms ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA…

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
16970245 Huang CF, Wang YR, Yen CH, Chou SH, Lau YT: Paraquat-induced lipid peroxidation: effects of ovariectomy and estrogen receptor antagonist. Chin J Physiol. 2006 Jun 30;49(3):141-6.
32(0,1,1,2) Details
20128815 Manthey D, Gamerdinger M, Behl C: The selective beta (1)-adrenoceptor antagonist nebivolol is a potential oestrogen receptor agonist with neuroprotective abilities. Br J Pharmacol. 2010 Feb 1.

Experimental approach: Human neuroepithelioma SK-N-MC cells stably transfected with human ER alpha and beta, and mouse N2A neuroblastoma cells expressing human APP695 (SWE)[N2Aswe, stably transfected with the Swedish mutation form of the Alzheimer-associated amyloid precursor protein (APPswe, K670M/N671L)] were incubated with different concentrations of nebivolol and 17beta-oestradiol (E2) for 24-48 h.
Furthermore, cell survival rates were determined, and oxidative stress was induced by hydrogen peroxide and paraquat.
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15325966 Gelinas S, Bureau G, Valastro B, Massicotte G, Cicchetti F, Chiasson K, Gagne B, Blanchet J, Martinoli MG: Alpha and beta estradiol protect neuronal but not native PC12 cells from paraquat-induced oxidative stress. Neurotox Res. 2004;6(2):141-8.

Paraquat also decreases estrogen receptor alpha in neuronal PC12 cells, thus suggesting new routes for paraquat to collapse cellular metabolism.
31(0,1,1,1) Details