Protein Information

Name alanine aminotransferase
Synonyms AAT1; AAT1; GPT; ALT 1; ALT1; Alanine aminotransferase; Alanine aminotransferase 1; GPT 1…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
9626535 Karan V, Vitorovic S, Tutundzic V, Poleksic V: Functional enzymes activity and gill histology of carp after copper sulfate exposure and recovery. Ecotoxicol Environ Saf. 1998 May-Jun;40(1-2):49-55.

After a 14-day period of exposure to five concentrations of copper sulfate (0.25-4.0 mg/L CuSO4, values ranging from approximately 5 to 70% of the 96-h LC-50) and a recovery period of the same duration, activities of the functional enzymes alkaline phosphatase (AP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the blood serum and gills were determined.
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19685012 Arredondo M, Nunez H, Lopez G, Pizarro F, Ayala M, Araya M: Influence of Estrogens on Copper Indicators: In Vivo and In Vitro Studies. Biol Trace Elem Res. 2009 Aug 14.

Participants received 8 mg Cu/day (as copper sulfate) during 6 months.
Serum Cp and Cu, Cu-Zn-superoxide dismutase activity, liver function indicators [aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyltransferase (GGT)], and serum Fe and Zn concentrations were measured monthly.
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11003114 Zhang SS, Noordin MM, Rahman SO, Haron J: Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats. Vet Hum Toxicol. 2000 Oct;42(5):261-4.


Liver Cu concentration and alanine aminotransferase (ALT) activity were also determined.
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12209195 Hebert C: NTP technical report on the toxicity studies of Cupric Sulfate (CAS No. 7758-99-8) Administered in Drinking Water and Feed to F344/N Rats and B6C3F1 Mice. Toxic Rep Ser. 1993 Jul;29:1-D3.

Increases in serum alanine aminotransferase and sorbitol dehydrogenase activities in both sexes were indicative of hepatocellular damage, as were increases in 5'-nucleotidase and bile salts in males.
Synonyms: Chalcanthite; Copper sulfate; cupric sulfate pentahydrate; bluestone; blue vitriol; Roman vitriol; Salzburg vitriol. (NOTE: These studies were supported in part by funds from the Comprehensive Environmental Response, Compensation, and Liability Act trust fund (Superfund) by an interagency agreement with the Agency for Toxic Substances and Disease Registry, U.S.
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18289470 Li YW, Wang XH, Nin Q, Luo XP: [Excessive copper induces hepatocyte apoptosis and affects Bax and Bcl-2 expression in rat liver]. Zhongguo Dang Dai Er Ke Za Zhi. 2008 Feb;10(1):42-6.

METHODS: Rat model of hepatolenticular degeneration was established by administering forages containing 1g/kg of copper sulfate and drinking water containing 0.185% copper sulfate.
Copper level in the liver and serum and alanine aminotransferase (ALT) level in serum were measured using an atomic absorption spectrophotometer.
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8310452 Ahmed HM, Shoka AA: Toxic interactions between copper sulphate and some organic agrochemicals. Toxicol Lett. 1994 Jan;70(1):109-19.


Alanine aminotransferase (ALT) activity was significantly increased, while cholinesterase (ChE) activity was decreased in all treated groups.
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