| Name | 5 HT 3 receptor |
|---|---|
| Synonyms | 5 HT 3; 5 hydroxytryptamine 3 receptor; serotonin receptor; HTR 3; HTR3; 5 HT3; 5 HT3A; 5 HT3R… |
| Name | copper sulfate |
|---|---|
| CAS | sulfuric acid copper(2+) salt (1:1) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8282015 | Fukui H, Yamamoto M, Sasaki S, Sato S: Involvement of 5-HT3 receptors and vagal afferents in copper sulfate- and cisplatin-induced emesis in monkeys. Eur J Pharmacol. 1993 Nov 2;249(1):13-8. |
224(2,4,4,4) | Details |
| 8846809 | Ito C, Isobe Y, Kijima H, Kiuchi Y, Ohtsuki H, Kawamura R, Tsuchida K, Higuchi S: The anti-emetic activity of GK-128 in Suncus murinus. Eur J Pharmacol. 1995 Oct 4;285(1):37-43. The 5-HT3 receptor agonist, 2-methyl- and copper sulfate also induced emesis of short duration. |
84(1,1,1,4) | Details |
| 9085045 | Minami M, Endo T, Tamakai H, Ogawa T, Hamaue N, Hirafuji M, Monma Y, Yoshioka M, Hagihara K: Antiemetic effects of N-3389, a newly synthesized 5-HT3 and 5-HT4 receptor antagonist, in ferrets. Eur J Pharmacol. 1997 Mar 5;321(3):333-42. The antiemetic activity of N-3389 (endo-3,9-dimethyl-3,9-diazabicyclo [3,3,1] non-7-yl-1 H-indazole-3-carboxamide dihydrochloride), a new 5-HT3 and 5-HT4 receptor antagonist, against cisplatin-, cyclophosphamide- and copper sulfate-induced emesis was investigated using ferrets. |
83(1,1,1,3) | Details |
| 16079468 | Nakayama H, Yamakuni H, Higaki M, Ishikawa H, Imazumi K, Matsuo M, Mutoh S: Antiemetic activity of FK1052, a 5-HT3- and 5-HT4-receptor antagonist, in Suncus murinus and ferrets. J Pharmacol Sci. 2005 Aug;98(4):396-403. Epub 2005 Jul 29. We investigated the effect of FK1052 [(+)-8,9-dihydro-10-methyl-7-[(5-methyl-1H--4-yl) methyl] pyrido [1,2 -a] indol-6 (7H)-one hydrochloride], a 5-HT3- and 5-HT4-receptor antagonist, on the emesis induced by motion stimuli, copper sulfate, or cisplatin in either Suncus murinus or ferrets and also clarified the role of the 5-HT3 and 5-HT4 receptors in these models. |
32(0,1,1,2) | Details |
| 8082706 | Fukui H, Yamamoto M, Sasaki S, Sato S: Possible involvement of peripheral 5-HT4 receptors in copper sulfate-induced vomiting in dogs. Eur J Pharmacol. 1994 May 12;257(1-2):47-52. The involvement of visceral afferent fibers and 5-HT3 or 5-HT4 receptors in the vomiting induced by oral administration of copper sulfate was investigated in beagle dogs. |
31(0,1,1,1) | Details |
| 1548679 | Youssefyeh RD, Campbell HF, Airey JE, Klein S, Schnapper M, Powers M, Woodward R, Rodriguez W, Golec S, Studt W, et al.: Development of high-affinity 5-HT3 receptor antagonists. 2. J Med Chem. 1992 Mar 6;35(5):903-11. However, it was inactive against apomorphine or copper sulfate-induced vomiting. |
5(0,0,0,5) | Details |
| 2041220 | Torii Y, Saito H, Matsuki N: Selective blockade of cytotoxic drug-induced emesis by 5-HT3 receptor antagonists in Suncus murinus. Jpn J Pharmacol. 1991 Jan;55(1):107-13. Veratrine, copper sulfate, cisplatin, cyclophosphamide and motion sickness were used as emetic stimuli. |
4(0,0,0,4) | Details |
| 12087874 | Yamamoto K, Matsunaga S, Matsui M, Takeda N, Yamatodani A: Pica in mice as a new model for the study of emesis. . Methods Find Exp Clin Pharmacol. 2002 Apr;24(3):135-8. However, emetogenic stimuli such as anticancer drugs, apomorphine, copper sulfate and rotation induced pica, a behavior characterized by eating nonfood substances such as kaolin, in rats. Cisplatin (5 mg/kg) caused a significant increase in kaolin consumption (saline: 0.15 +/- 0.08 g vs. cisplatin: 0.45 +/- 0.16 g) and pretreatment with the 5-HT3 receptor antagonist, (2 mg/kg), suppressed the increased consumption (vehicle: 0.33 +/- 0.05 g vs. 0.13 +/- 0.04 g). |
1(0,0,0,1) | Details |
| 1972549 | Costall B, Domeney AM, Naylor RJ, Owera-Atepo JB, Rudd JA, Tattersall FD: Fluphenazine, ICS 205-930 and dl-fenfluramine differentially antagonise drug-induced emesis in the ferret. Neuropharmacology. 1990 May;29(5):453-62. The data indicate that and/or 5-HT3 receptor systems are involved in drug-induced emesis but that emesis caused by gastric irritation induced by sulphate is mediated by different receptor mechanisms. |
1(0,0,0,1) | Details |
| 8415820 | Takeda N, Hasegawa S, Morita M, Matsunaga T: Pica in rats is analogous to emesis: an animal model in emesis research. Pharmacol Biochem Behav. 1993 Aug;45(4):817-21. Oral administration of copper sulfate and intraperitoneal injection of cisplatin also induced dose-dependent kaolin consumption. These findings suggest that pica in rats was induced through 1) dopamine D2 receptors in the chemoreceptor trigger zone, and 2) the stomach, partly via 5-HT3 receptors in the visceral afferents in the stomach wall. |
1(0,0,0,1) | Details |
| 10688616 | Yamakuni H, Sawai H, Maeda Y, Imazumi K, Sakuma H, Matsuo M, Mutoh S, Seki J: Probable involvement of the 5-hydroxytryptamine (4) receptor in methotrexate-induced delayed emesis in dogs. J Pharmacol Exp Ther. 2000 Mar;292(3):1002-7. The emetic episodes induced by MTX were also inhibited by another 5-HT (3/4) receptor antagonist, tropisetron (1 mg/kg). Copper sulfate-induced emesis in dogs was also prevented by FK1052, tropisetron, and CP-122,721 but not by |
1(0,0,0,1) | Details |
| 9258999 | Matsuki N, Wang CH, Okada F, Tamura M, Ikegaya Y, Lin SC, Hsu YN, Chaung LJ, Chen SJ, Saito H: Male/female differences in drug-induced emesis and motion sickness in Suncus murinus. Pharmacol Biochem Behav. 1997 Aug;57(4):721-5. In order to elucidate possible male/female differences in emesis, the effects of various emetogenic drugs (cisplatin, copper sulfate, veratrine, and motion stimulus were compared between male and female Suncus murinus. The ID50 values for tropisetron, a 5-HT3 receptor antagonist, to block -induced emesis were also similar between male and female animals. |
1(0,0,0,1) | Details |