Protein Information

Name calcineurin (protein family or complex)
Synonyms Calcineurin; Calcineurins; Protein phosphatase 2B

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
12147265 Sommer D, Coleman S, Swanson SA, Stemmer PM: Differential susceptibilities of serine/threonine phosphatases to oxidative and nitrosative stress. Arch Biochem Biophys. 2002 Aug 15;404(2):271-8.

Although superoxide, generated from xanthine/xanthine oxidase or paraquat, and NO, generated from (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide or sodium nitroprusside, potently inhibited the phosphatase activity of calcineurin in neuroblastoma cell lysates, they had relatively little effect on the activities of PP1 or PP2A.
85(1,1,1,5) Details
10759856 Sommer D, Fakata KL, Swanson SA, Stemmer PM: Modulation of the phosphatase activity of calcineurin by oxidants and antioxidants in vitro. Eur J Biochem. 2000 Apr;267(8):2312-22.

7(0,0,0,7) Details
12203019 Reiter TA, Rusnak F: Is calcineurin a peroxide-specific sensor in T-lymphocytes? . J Biol Inorg Chem. 2002 Sep;7(7-8):823-34. Epub 2002 May 14.

Similarly, treatment of T-lymphocytes with NaOCl and paraquat does not drastically alter the activity of calcineurin in crude cell lysate, while H (2) O (2) causes significant inhibition.
7(0,0,0,7) Details
17324120 Agbas A, Hui D, Wang X, Tek V, Zaidi A, Michaelis EK: Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo. Biochem J. 2007 Jul 1;405(1):51-9.

2(0,0,0,2) Details