Protein Information

Name TIMP 1
Synonyms CLGI; Collagenase inhibitor; EPA; EPO; Erythroid potentiating activity; Fibroblast collagenase inhibitor; HCI; Metalloproteinase inhibitor 1…

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
19272247 Shao CF, Chang XL, Wu QE, Ban TT, Jiang N, Yao XM, Zhou ZJ: [Influence of pyrrolidine dithiocarbamate (PDTC) on expression of transforming growth factor beta (1), matrix metalloproteinase-2 and tissue inhibitor-1 of metalloproteinase in rats with pulmonary damage induced by paraquat]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008 Oct;26(10):577-82.

OBJECTIVE: To investigate the influence of pyrrolidine dithiocarbamate (PDTC) on the expression of transforming growth factor beta (1) (TGF-beta (1)), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor-1 of metalloproteinase (TIMP-1) in rats with pulmonary damage induced by paraquat (PQ).
40(0,1,2,5) Details
11746190 Nakamura T, Ushiyama C, Shimada N, Hayashi K, Ebihara I, Suzaki M, Koide H: Changes in concentrations of type IV collagen and tissue inhibitor of metalloproteinase-1 in patients with paraquat poisoning. J Appl Toxicol. 2001 Nov-Dec;21(6):445-7.
20(0,0,3,5) Details
12882763 Ruiz V, Ordonez RM, Berumen J, Ramirez R, Uhal B, Becerril C, Pardo A, Selman M: Unbalanced collagenases/TIMP-1 expression and epithelial apoptosis in experimental lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2003 Nov;285(5):L1026-36. Epub 2003 Jul 25.

In this study, we examined the sequential expression of several matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), and growth factors as well as the presence of apoptosis in a model of pulmonary fibrosis induced in rats with paraquat and hyperoxia.
3(0,0,0,3) Details