| Name | superoxide dismutase |
|---|---|
| Synonyms | IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16049674 | Hu X, Jiang M, Zhang A, Lu J: Abscisic acid-induced apoplastic H2O2 accumulation up-regulates the activities of chloroplastic and cytosolic antioxidant enzymes in maize leaves. Planta. 2005 Dec;223(1):57-68. Epub 2005 Jul 28. Meanwhile, ABA treatment led to a significant increase in the activities of the leaf chloroplastic and cytosolic antioxidant enzymes superoxide dismutase (SOD), peroxidase (APX) and glutathione reductase (GR), and pretreatment with the oxidase inhibitor diphenyleneiodonium (DPI), the O (2) (-) scavenger Tiron and the H (2) O (2) scavenger dimethylthiourea (DMTU) almost completely arrested the increase in the activities of these antioxidant enzymes. Moreover, an oxidative stress induced by paraquat (PQ), which generates O (2) (-) and then H (2) O (2) in chloroplasts, also up-regulated the activities of the chloroplastic and cytosolic antioxidant enzymes, and the up-regulation was blocked by the pretreatment with Tiron and DMTU. |
1(0,0,0,1) | Details |
| 12554087 | Schott EJ, Vasta GR: The PmSOD1 gene of the protistan parasite Perkinsus marinus complements the sod2Delta mutant of Saccharomyces cerevisiae, and directs an iron superoxide dismutase to mitochondria. Mol Biochem Parasitol. 2003 Jan;126(1):81-92. |
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| 10754530 | Suzuki Y, Kondo Y, Himeno S, Nemoto K, Akimoto M, Imura N: Role of antioxidant systems in human androgen-independent prostate cancer cells. Prostate. 2000 May 1;43(2):144-9. METHODS: Three cell lines of human hormone-independent prostate cancer (PC-3, PC-3 MA2, and HPC36M) were examined for activities of superoxide dismutase, catalase, and peroxidase, and for levels of protein and nonprotein thiols such as metallothionein, and thioredoxin. Sensitivity of these cells to anticancer drugs and inducers of reactive species such as paraquat, tert-butylhydroperoxide, and peroxide was determined by microtiter assay. |
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| 12167315 | Jaiswal R, Khan MA, Musarrat J: Photosensitized paraquat-induced structural alterations and free radical mediated fragmentation of serum albumin. J Photochem Photobiol B. 2002 Jul;67(3):163-70. The results with the free radical quenchers such as and superoxide dismutase (SOD) clearly reflected the involvement of *OH radicals in protein fragmentation process. |
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| 19329562 | Oracz K, El-Maarouf-Bouteau H, Kranner I, Bogatek R, Corbineau F, Bailly C: The mechanisms involved in seed dormancy alleviation by unravel the role of reactive species as key factors of cellular signaling during germination. Plant Physiol. 2009 May;150(1):494-505. Epub 2009 Mar 27. This increase results from an inhibition of catalase and superoxide dismutase activities and also involves activation of oxidase. |
1(0,0,0,1) | Details |
| 14555815 | Hong SY, Yang JO, Lee EY, Lee ZW: Effects of N-acetyl- and on antioxidant status of human serum and 3T3 fibroblasts. Plant Physiol Biochem. 2005 Jan;43(1):55-60. Epub 2005 Jan 22. The effectiveness of several sulfhydryl compounds in the treatment of paraquat intoxication has been previously tested based on their antioxidant ability. As a preliminary pharmacokinetic study on sulfhydryl compounds, we attempted to establish the optimal concentration of N-acetyl- superoxide dismutase, and catalase. |
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| 12914767 | Goulielmos GN, Arhontaki K, Eliopoulos E, Tserpistali K, Tsakas S, Loukas M: Drosophila Cu,Zn superoxide dismutase gene confers resistance to paraquat in Escherichia coli. Biochem Biophys Res Commun. 2003 Aug 29;308(3):433-8. |
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| 19645869 | Shopova VL, Dancheva VY, Salovsky PT, Stoyanova AM: Protective effects of a superoxide dismutase/catalase mimetic compound against paraquat pneumotoxicity in rat lung. Respirology. 2009 May;14(4):504-10. |
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| 15941311 | Wilmsen PK, Spada DS, Salvador M: Antioxidant activity of the in chemical and biological systems. J Agric Food Chem. 2005 Jun 15;53(12):4757-61. Biological studies were done using the eukaryotic cells of superoxide-dismutase proficient and deficient strains of Saccharomyces cerevisiae treated with and the stressing agents peroxide or paraquat (methylviologen; 1,1'-dimethyl-4,4'-bipyridinium dichloride). |
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| 15824117 | Thiruchelvam M, Prokopenko O, Cory-Slechta DA, Buckley B, Mirochnitchenko O: Overexpression of superoxide dismutase or peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. Pharmacol Toxicol. 2000 Mar;86(3):102-9. |
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| 17569284 | Ray S, Sengupta A, Ray A: Effects of paraquat on anti-oxidant system in rats. Indian J Exp Biol. 2007 May;45(5):432-8. Glutathione reductase and glucose-6-phosphate dehydrogenase activity decreased, whereas the activity of glutathione-S-transferase, peroxidase, catalase and superoxide dismutase increased in paraquat exposure. |
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| 20211647 | Chen Q, Niu Y, Zhang R, Guo H, Gao Y, Li Y, Liu R: The toxic influence of paraquat on hippocampus of mice: Involvement of oxidative stress. Neurotoxicology. 2010 Mar 6. The activities of total superoxide dismutase (SOD) in the hippocampus of mice decreased significantly after treatment with paraquat. |
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| 10752666 | Tsukamoto M, Tampo Y, Sawada M, Yonaha M: Paraquat-induced membrane dysfunction in pulmonary microvascular endothelial cells. Hum Exp Toxicol. 2001 Dec;20(12):637-41. Lactate dehydrogenase release 72 hr after exposure to 0.5 mM paraquat was prevented strongly by catalase (1000 units/ml), but weakly by superoxide dismutase (1000 units/ml). |
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| 16923916 | Bakshi CS, Malik M, Regan K, Melendez JA, Metzger DW, Pavlov VM, Sellati TJ: Superoxide dismutase B gene (sodB)-deficient mutants of Francisella tularensis demonstrate hypersensitivity to oxidative stress and attenuated virulence. J Bacteriol. 2006 Sep;188(17):6443-8. |
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| 16097801 | Wallace MA, Bailey S, Fukuto JM, Valentine JS, Gralla EB: Induction of phenotypes resembling CuZn-superoxide dismutase deletion in wild-type yeast cells: an in vivo assay for the role of in the toxicity of redox-cycling compounds. Chem Res Toxicol. 2005 Aug;18(8):1279-86. Such cells are exquisitely sensitive to small amounts of the herbicide paraquat (methyl viologen), which is known to produce high fluxes of in vivo via a redox-cycling mechanism. |
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| 17906124 | Kang YS, Lee Y, Jung H, Jeon CO, Madsen EL, Park W: Overexpressing antioxidant enzymes enhances naphthalene biodegradation in Pseudomonas sp. strain As1. Microbiology. 2007 Oct;153(Pt 10):3246-54. Our approach was to prepare plasmid constructs that conferred expression of two single antioxidant enzymes [Fpr (ferredoxin- (+) reductase) and SOD (superoxide dismutase)] and the pair of enzymes SOD plus AhpC (alkyl hydroperoxide reductase). All antioxidant-overexpressing recombinant strains, with the exception of one with an upregulated sodA gene due to the lac promoter [strain As1 (sodA)], exhibited resistance to the generating agent paraquat (PQ). |
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| 16162242 | Abrashev R, Dolashka P, Christova R, Stefanova L, Angelova M: Role of antioxidant enzymes in survival of conidiospores of Aspergillus niger 26 under conditions of temperature stress. J Appl Microbiol. 2005;99(4):902-9. AIMS: A better understanding of the role of antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT) in the protection of Aspergillus niger spores against thermal stress. We compared the influence of heat shock and -generating agent paraquat on growth and antioxidant enzyme defence and found different response to the both type of stresses. |
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| 11520895 | Li QY, Pedersen C, Day BJ, Patel M: Dependence of excitotoxic neurodegeneration on mitochondrial aconitase inactivation. J Neurochem. 2001 Aug;78(4):746-55. To determine if mitochondrial O2 (-) production was an important determinant in neuronal death resulting from OGD, metalloporphyrins with varying superoxide dismutase (SOD) activity were tested for their ability to protect against mitochondrial aconitase inactivation and cell death. |
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| 19778406 | Ding HD, Zhang XH, Xu SC, Sun LL, Jiang MY, Zhang AY, Jin YG: Induction of protection against paraquat-induced oxidative damage by abscisic acid in maize leaves is mediated through mitogen-activated protein kinase. J Integr Plant Biol. 2009 Oct;51(10):961-72. Two inhibitors also suppressed the total activities of the antioxidant enzymes superoxide dismutase (SOD, EC 1.15.1.1), catalase (CAT, EC 1.11.1.6), peroxidase (APX, EC 1.11.1.11), and glutathione reductase (GR, EC 1.6.4.2). |
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| 10498818 | Noack H, Possel H, Rethfeldt C, Keilhoff G, Wolf G: mediated damage and lowered tolerance in primary cortical glial cultures after induction of the inducible isoform of NOS. Glia. 1999 Oct;28(1):13-24. Among the ROS scavenging enzymes superoxide dismutase (Cu/Zn- and Mn-isoform), peroxidase and catalase only mitochondrial Mn-SOD was found to be upregulated in the course of i-NOS induction (Western blots). Elevated levels of generated either intracellularly by paraquat or extracellularly via xanthine oxidase and resulted dose-dependently in a larger decline of cell viability in the .NO forming cultures compared to controls (release of lactate dehydrogenase, citrate synthase, stainability by propidium iodide, and tetramethylrhodamine). |
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| 19404744 | Lee DH, Oh KH, Kahng HY: Molecular analysis of antioxidant genes in the extremohalophile marine bacterium Exiguobacterium sp. Biotechnol Lett. 2009 Aug;31(8):1245-51. Epub 2009 Apr 29. Representative antioxidant genes of catalase and superoxide dismutase (SOD), obtained by PCR amplification of the genomic DNA, were characterized: the 252-bp catalase gene shared 77% similarity in the deduced amino acid sequence to that of E. oxidotolerans T-2-2 (T). RT-PCR-based expression analysis at the transcriptional level suggested that the catalase gene is strongly expressed in response to 2 mM H (2) O (2), 0.2 mM Paraquat and 0.2 mM |
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| 15839099 | Angelova MB, Pashova SB, Spasova BK, Vassilev SV, Slokoska LS: Oxidative stress response of filamentous fungi induced by peroxide and paraquat. Mycol Res. 2005 Feb;109(Pt 2):150-8. Cell responses against both and peroxide stresses include enhanced expression of superoxide dismutase (SOD) and catalase, however, the extent was different: treatment with PQ increased mainly SOD, whereas exogenous H2O2 led to enhanced catalase. |
1(0,0,0,1) | Details |
| 15203195 | Keaney M, Matthijssens F, Sharpe M, Vanfleteren J, Gems D: Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans. Free Radic Biol Med. 2004 Jul 15;37(2):239-50. Using the nematode Caenorhabditis elegans, we tested the effects on stress resistance and life span of treatment with EUK-8 and EUK-134, synthetic mimetics of the antioxidant enzyme superoxide dismutase (SOD), which neutralises Where life span was reduced by the generators paraquat and plumbagin, EUK-8 treatment increased life span in a dose-dependent fashion. |
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| 17048122 | Kinoshita A, Kobayashi D, Saitoh Y, Tanabe N, Uchino K, Nishiguchi K, Okumura K, Komada F: Regulation of exogenous gene expression by . Pharm Res. 2006 Nov;23(11):2536-41. Epub 2006 Oct 18. METHODS: We used two plasmids (1) pQBI25 encoding CMV-LTR and red-shift green fluorescent protein (rsGFP) cDNA and (2) pRc/CMV-SOD encoding CMV-LTR and human Cu, Zn-superoxide dismutase (SOD) cDNA. Each type of cell was exposed to radicals using paraquat for 24 h. |
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| 11389724 | Jacob C, Courbot M, Brun A, Steinman HM, Jacquot JP, Botton B, Chalot M: Molecular cloning, characterization and regulation by cadmium of a superoxide dismutase from the ectomycorrhizal fungus Paxillus involutus. Eur J Biochem. 2001 Jun;268(11):3223-32. Complementation of an Escherichia coli SOD null strain that is unable to grow in the presence of paraquat or cadmium indicated that cloned Pisod encoded a functional superoxide dismutase. |
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| 18686095 | Ullmann K, Wiencierz AM, Muller C, Thierbach R, Steege A, Toyokuni S, Steinberg P: A high-throughput reporter gene assay to prove the ability of natural compounds to modulate peroxidase, superoxide dismutase and catalase gene promoters in V79 cells. Free Radic Res. 2008 Aug;42(8):746-53. paraquat and led to a statistically significant increase in the peroxidase and superoxide dismutase gene promoter activities. |
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| 18454199 | Kanazawa T, Zappaterra MD, Hasegawa A, Wright AP, Newman-Smith ED, Buttle KF, McDonald K, Mannella CA, van der Bliek AM: The C. elegans Opa1 homologue EAT-3 is essential for resistance to free radicals. PLoS Genet. 2008 Feb 29;4(2):e1000022. Moreover, eat-3 mutants are hypersensitive to paraquat, which promotes damage by free radicals, and they are sensitive to loss of the mitochondrial superoxide dismutase sod-2. |
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| 19938450 | Zhao Y, Li J, Chen Y, Huang H, Yu Z: [Impact of exogenous paraquat on enzyme exudation and biochemical changes of lignin degradation fungi]. J Biol Chem. 2005 Jun 10;280(23):22530-9. Epub 2005 Apr 11. Also, addition of paraquat enhanced activity of superoxide dismutase (SOD) and catalase (CAT) in the first 48 h. |
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| 19100713 | Takada S, Inoue E, Tano K, Yoshii H, Abe T, Yoshimura A, Akita M, Tada S, Watanabe M, Seki M, Enomoto T: Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD2. Biochem Biophys Res Commun. 2009 Feb 6;379(2):233-8. Epub 2008 Dec 25. In addition, these cells showed a high sensitivity to paraquat, which produces and died through apoptosis. |
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| 18450220 | Krasowska A, Sigler K: Cell-protective and antioxidant activity of two groups of synthetic amphiphilic compounds--phenolics and amine N-oxides. Folia Microbiol. 2007;52(6):585-92. Phenolic antioxidants protect yeast cells exposed to the producer paraquat and peroxyl generator tert-butylhydroperoxide better than N-oxides at 3-fold higher concentration. Both types of antioxidants enhance the survival of pro-oxidant-exposed cells of S. cerevisiae mutants deficient in cytosolic and/or mitochondrial superoxide dismutase and could be good compounds which mimic the role of superoxide dismutases. |
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| 12934716 | Paul A, Duttaroy A: Genomic regions responsible for manganese superoxide dismutase regulation in Drosophila melanogaster. Aging Cell. 2003 Aug;2(4):223-31. Changes in MnSOD expression were positively associated with paraquat sensitivity of the deletion genotypes. |
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| 15166213 | Wallace MA, Liou LL, Martins J, Clement MH, Bailey S, Longo VD, Valentine JS, Gralla EB: inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. J Biol Chem. 2004 Jul 30;279(31):32055-62. Epub 2004 May 27. Cross-compartment protection by CuZn-superoxide dismutase.. |
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| 16442589 | Magwere T, West M, Riyahi K, Murphy MP, Smith RA, Partridge L: The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster. Mech Ageing Dev. 2006 Apr;127(4):356-70. Epub 2006 Jan 25. We used the fruit fly Drosophila melanogaster to test the effects of feeding the superoxide dismutase (SOD) mimetic drugs Euk-8 and -134 and the mitochondria-targeted mitoquinone (MitoQ) on lifespan and oxidative stress resistance of wild type and SOD-deficient flies. All three drugs showed a dose-dependent increase in toxicity in wild type flies, an effect that was exacerbated in the presence of the redox-cycling drug paraquat. |
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| 16986793 | Pflugmacher S, Jung K, Lundvall L, Neumann S, Peuthert A: Effects of cyanobacterial toxins and cyanobacterial cell-free crude extract on germination of alfalfa (Medicago sativa) and induction of oxidative stress. Environ Toxicol Chem. 2006 Sep;25(9):2381-7. These systems consist of enzymes, such as superoxide dismutase, catalase, and peroxidase, and nonenzymatic substances, such as or vitamins. |
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| 16186101 | Yamamoto M, Clark JD, Pastor JV, Gurnani P, Nandi A, Kurosu H, Miyoshi M, Ogawa Y, Castrillon DH, Rosenblatt KP, Kuro-o M: Regulation of oxidative stress by the anti-aging hormone klotho. . J Biol Chem. 2005 Nov 11;280(45):38029-34. Epub 2005 Sep 26. Klotho protein activates the FoxO forkhead transcription factors that are negatively regulated by insulin/IGF-1 signaling, thereby inducing expression of manganese superoxide dismutase. |
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| 19777209 | Todorova TT, Petrova VY, Vuilleumier S, Kujumdzieva AV: Response to different oxidants of Saccharomyces cerevisiae ure2Delta mutant. Arch Microbiol. 2009 Nov;191(11):837-45. Epub 2009 Sep 24. Data for the lack of significant effect of URE2 disruption on the cellular growth in the presence of paraquat and were obtained. The important role of Ure2p in in vivo -mediated reactive species (ROS) scavenging was shown by measuring the activity of antioxidant enzymes peroxidase, superoxide dismutase (SOD) and catalase in an URE2 disrupted strain. |
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| 10855709 | Belo I, Pinheiro R, Mota M: Response of the thermophile Thermus sp. Appl Microbiol Biotechnol. 2000 May;53(5):517-24. Cell productivity was improved by pressurisation up to 0.56 MPa for batch cultivation; and an induction of the antioxidant enzymes, superoxide dismutase and catalase, was observed with the rise in pressure. Cell pre-cultivation under pressurised conditions conferred to the cells more resistance to an exposure to peroxide and more sensitivity to paraquat (methyl viologen). |
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| 19761460 | Park SJ, Chung HY, Lee JH: Rapid in vivo screening system for anti-oxidant activity using bacterial redox sensor strains. J Appl Microbiol. 2009 Aug 6. The activities of SoxR and OxyR, the bacterial redox sensors, were monitored to probe the intracellular redox status through two reporter strains, Escherichia coli soxS (p)-lacZ and oxyS (p)-lacZ fusions, which specifically respond to paraquat, a generator, and H (2) O (2), respectively, with practically no cross reactivity. Finally, rutin and significantly restored the viability of a superoxide dismutase mutant that has limited viability because of defective defence against oxidative stress. |
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| 11156968 | Copin JC, Gasche Y, Li Y, Chan PH: Prolonged hypoxia during cell development protects mature manganese superoxide dismutase-deficient astrocytes from damage by oxidative stress. FASEB J. 2001 Feb;15(2):525-34. An initial hypoxic environment increases the resistance of manganese superoxide dismutase-deficient astrocytes to radicals artificially produced by paraquat treatment, preserves respiratory activity, and allows normoxic division during a subsequent passage. |
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| 17640563 | Samai M, Sharpe MA, Gard PR, Chatterjee PK: Comparison of the effects of the superoxide dismutase mimetics EUK-134 and tempol on paraquat-induced nephrotoxicity. Free Radic Biol Med. 2007 Aug 15;43(4):528-34. Epub 2007 May 16. |
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| 14503839 | Lee TB, Lim DY, Jeon HJ, Min YD, Kim KC, Kim KJ, Choi CH: Differential induction of Mn-containing superoxide dismutase by paraquat in peripheral lymphocytes of normal subjects and gastric cancer patients. Mol Cells. 2003 Aug 31;16(1):13-8. |
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| 12531458 | Mollace V, Iannone M, Muscoli C, Palma E, Granato T, Rispoli V, Nistico R, Rotiroti D, Salvemini D: The role of oxidative stress in paraquat-induced neurotoxicity in rats: protection by non peptidyl superoxide dismutase mimetic. Neurosci Lett. 2003 Jan 2;335(3):163-6. |
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| 14720215 | Hinerfeld D, Traini MD, Weinberger RP, Cochran B, Doctrow SR, Harry J, Melov S: Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice. J Neurochem. 2004 Feb;88(3):657-67. Most prior studies have tested oxidative stress paradigms in mitochondria through either chemical inhibition of specific components of the respiratory chain, or adding an exogenous insult such as peroxide or paraquat to directly damage mitochondria. |
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| 17522887 | Su Z, Chai MF, Lu PL, An R, Chen J, Wang XC: AtMTM1, a novel mitochondrial protein, may be involved in activation of the manganese-containing superoxide dismutase in Arabidopsis. Planta. 2007 Sep;226(4):1031-9. Epub 2007 May 24. Related mRNA-level analysis showed the AtMTM1 gene is induced by paraquat but not by peroxide, which indicates that this gene is related to the superoxide scavenger SOD. |
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| 19093460 | Yainoy S, Isarankura-Na-Ayudhya C, Tantimongcolwat T, Prachayasittikul V: Cloning of active human manganese superoxide dismutase and its oxidative protection in Escherichia coli. Pak J Biol Sci. 2007 Oct 15;10(20):3541-8. More interestingly, E. coli expressing hMnSOD provides resistance against oxidative stress induced by the herbicide paraquat up to 1.2 mM. |
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| 16081500 | Tauskela JS, Brunette E, O'Reilly N, Mealing G, Comas T, Gendron TF, Monette R, Morley P: An alternative Ca2+-dependent mechanism of neuroprotection by the metalloporphyrin class of superoxide dismutase mimetics. FASEB J. 2005 Oct;19(12):1734-6. Epub 2005 Aug 4. Results from paraquat toxicity, intracellular fluorescence quenching, electrophysiology, mitochondrial Ca2+, and spontaneous synaptic activity experiments suggest a model in which metalloporphyrins, acting at the plasma membrane, protect neurons against OGD by suppressing postsynaptic NMDA receptor-mediated Ca2+ rises, thereby indirectly preventing accumulation of mitochondrial Ca2+ levels. |
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| 14500512 | Plewes KA, Barr SD, Gedamu L: superoxide dismutases targeted to the glycosomes of Leishmania chagasi are important for survival. Infect Immun. 2003 Oct;71(10):5910-20. The parasites with these genes exhibited a significant reduction in growth when endogenous levels were increased with paraquat in culture. |
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| 11021919 | Baysse C, De Vos D, Naudet Y, Vandermonde A, Ochsner U, Meyer JM, Budzikiewicz H, Schafer M, Fuchs R, Cornelis P: interferes with siderophore-mediated iron uptake in Pseudomonas aeruginosa. Microbiology. 2000 Oct;146 ( Pt 10):2425-34. Exposure of PAO1 cells to induced resistance to the -generating compound paraquat, and conversely, exposure to paraquat increased resistance to V (IV). Superoxide dismutase (SOD) activity of cells grown in the presence of V (IV) was augmented by a factor of two. |
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| 15000686 | Tkachenko AG: Mechanisms of protective functions of Escherichia coli polyamines against toxic effect of paraquat, which causes stress. Biochemistry. 2004 Feb;69(2):188-94. Of six genes studied, the maximum (to 130%), minimum (about 40%), and average (60-80%) stimulation was observed for the stress induction of nfo (endonuclease IV), sodA (superoxide dismutase), and the soxS gene of the transcriptional regulator, respectively. |
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| 12722655 | Vorob'eva LI, Khodzhaev EIu, Ponomareva GM, Briukhanov AL: [Extracellular protein metabolite of Luteococcus japonicus subsp. casei reactivates cells subjected to oxidative stress]. Prikl Biokhim Mikrobiol. 2003 Mar-Apr;39(2):202-7. A protein exometabolite isolated from the culture liquid of Luteococcus japonicus subsp. casei reactivates the cells of this microorganism, following H2O2 or paraquat-induced oxidative stress. The resistance of L. casei cells to these oxidizers is accounted for by the high activity of superoxide dismutase and catalase. |
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| 18074631 | Spiegelman BM: Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators. Novartis Found Symp. 2007;287:60-3; discussion 63-9. This includes genes encoding mitochondrial proteins like SOD2, but also includes cytoplasmic proteins such as catalase and GPX1. Cells lacking PGC1alpha are hypersensitive to death from oxidative stress caused by H2O2 or paraquat. |
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| 20002190 | Italiani VC, Braz VS, Xiao H, Steinman HM, Marques MV: Catalase-peroxidase activity is decreased in a Caulobacter crescentus rho mutant. FEMS Microbiol Lett. 2009 Nov 23. The mutant was shown to be permanently under oxidative stress, based on fluorophore oxidation, and also to be sensitive to tert-butyl hydroperoxide and paraquat. However, the results showed that the activities of superoxide dismutases CuZnSOD and FeSOD and the alkylhydroperoxide reductase ahpC mRNA levels in the rho mutant were comparable to the wild-type control in the exponential and stationary phases. |
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| 12624930 | Babykin MM, Sidoruk KV, Zinchenko VV, Nefedova LN, Cerff R, Shestakov SV: [On the involvement of the regulatory gene prqR in the development of resistance to methyl viologen in cyanobacterium Synechocystis sp. Genetika. 2003 Jan;39(1):25-32. In cells of the wild-type strain containing MV, the autorepressor activity of the PrqR protein enhances and transcription of mvrA and sodB genes encoding an respectively assumed transporter protein and iron-containing superoxide dismutase increases. |
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| 18315955 | Kim DW, Kim SY, Lee SH, Lee YP, Lee MJ, Jeong MS, Jang SH, Park J, Lee KS, Kang TC, Won MH, Cho SW, Kwon OS, Eum WS, Choi SY: Protein transduction of an antioxidant enzyme: subcellular localization of superoxide dismutase fusion protein in cells. BMB Rep. 2008 Feb 29;41(2):170-5. The viability of cells treated with paraquat was markedly increased by the transduced fusion proteins. |
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| 16775753 | Nomura CT, Sakamoto T, Bryant DA: Roles for heme- oxidases in extreme high-light and oxidative stress response in the cyanobacterium Synechococcus sp. Arch Microbiol. 2006 Jun;185(6):471-9. Epub 2006 Apr 27. The ctaDII mutant and the ctaDI-ctaDII double mutant cells had approximately twofold higher levels of superoxide dismutase (SOD) activity, indicating that the disruption of ctaDII gene increased the capacity to decompose active species. |
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| 10461909 | Gabbianelli R, Ferri A, Rotilio G, Carri MT: Aberrant chemistry as a major mediator of oxidative stress in a human cellular model of amyotrophic lateral sclerosis. J Neurochem. 1999 Sep;73(3):1175-80. We report that expression of mutant H46R Cu,Zn superoxide dismutase induces a selective increase in paraquat sensitivity that is reverted by addition of D-penicillamine. |
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| 17571795 | Krasowska A, Piasecki A, Murzyn A, Sigler K: Assaying the antioxidant and radical scavenging properties of aliphatic mono- and di-N-oxides in superoxide dismutase-deficient yeast and in a chemiluminescence test. Folia Microbiol. 2007;52(1):45-51. The antioxidative action of amphiphilic mono-(alkanoylamino) ethyldimethylamine-N-oxides (EDA), di-N-oxides 1,1-bis {[2-(N,N-dimethylamino) ethyl] amido}alkane-di-N-oxides (MEDA) and 1,1-bis {[3-(N,N-dimethylamino) propyl] amido}alkane-di-N-oxides (MPDA) with a 12- and 14-membered acyl chain against tert-butylhydroperoxide (TBHP)-produced peroxyl and paraquat (PQ)-generated radicals was determined in superoxide dismutase-deficient mutants of Saccharomyces cerevisiae, and, in parallel, in a chemical assay based on chemiluminescence changes caused in a luminol system by peroxyl radicals generated from the azo-compound 2,2'-azobis (2-amidinopropane dihydrochloride) (AAPH). |
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| 15359600 | Tertivanidis K, Goudoula C, Vasilikiotis C, Hassiotou E, Perl-Treves R, Tsaftaris A: Superoxide dismutase transgenes in sugarbeets confer resistance to oxidative agents and the fungus C. beticola. Transgenic Res. 2004 Jun;13(3):225-33. |
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| 16735730 | Brioukhanov AL, Netrusov AI, Eggen RI: The catalase and superoxide dismutase genes are transcriptionally up-regulated upon oxidative stress in the strictly anaerobic archaeon Methanosarcina barkeri. Microbiology. 2006 Jun;152(Pt 6):1671-7. The oxidative stress agent paraquat (PQ) suppressed growth of M. barkeri at concentrations of 50-200 microM. |
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| 16299000 | Kwon ES, Jeong JH, Roe JH: Inactivation of synthase causes auxotrophy in /zinc-containing superoxide dismutase-deficient yeast Schizosaccharomyces pombe. J Biol Chem. 2006 Jan 20;281(3):1345-51. Epub 2005 Nov 18. Treatment of exponentially growing S. pombe cells with paraquat, a generator, caused a decrease in the amount of Lys4 protein as expected. |
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| 10742227 | Kim YC, Miller CD, Anderson AJ: Superoxide dismutase activity in Pseudomonas putida affects utilization of sugars and growth on root surfaces. Appl Environ Microbiol. 2000 Apr;66(4):1460-7. The sodB and sodA sodB mutants were more sensitive than wild type to oxidative stress generated within the cell by paraquat treatment. |
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| 11811537 | Benov L, Al-Ibraheem J: metabolism in superoxide dismutase-deficient Escherichia coli. Free Radic Res. 2001 Dec;35(6):867-72. |
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| 10598954 | Yang MK, Kim YG: Protective role of -132 against paraquat-induced oxidative stress in the livers of senescence-accelerated mice. J Toxicol Environ Health A. 1999 Nov 12;58(5):289-97. In addition, Ge-132 significantly elevated the activities of hepatic superoxide dismutase (SOD) and catalase following PQ pretreatment. |
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| 18945933 | Wu L, Zhang Z, Zhang H, Wang XC, Huang R: Transcriptional modulation of ethylene response factor protein JERF3 in the oxidative stress response enhances tolerance of tobacco seedlings to salt, drought, and freezing. Plant Physiol. 2008 Dec;148(4):1953-63. Epub 2008 Oct 22. More importantly, this regulation of the expression of oxidative genes subsequently enhances the activities of superoxide dismutase but reduces the content of ROS in tobacco under drought, cold, salt, and abscisic acid treatments. |
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| 15754033 | Tomita M, Katsuyama H, Okuyama T, Hidaka K, Minatogawa Y: Changes in gene expression level for defense system enzymes against oxidative stress and level in rat administered paraquat. Int J Mol Med. 2005 Apr;15(4):689-93. At 16 h after PQ intake, the mRNA expression level of glutathione reductase (GR) showed the greatest increase, and those of catalase (CAT) and manganese-superoxide dismutase (MnSOD) showed more modest increases. |
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| 10490287 | Lagrange P, Romero IA, Minn A, Revest PA: Transendothelial permeability changes induced by free radicals in an in vitro model of the blood-brain barrier. Free Radic Biol Med. 1999 Sep;27(5-6):667-72. We have recently shown that a range of xenobiotics, including nitrofurazone, and methylviologen (paraquat) may undergo monoelectronic redox cycling in isolated brain capillaries, giving rise to reactive species. Pre-incubation with superoxide dismutase and catalase blocked changes in permeability to control levels in a dose-dependent manner, suggesting the involvement of reactive species in -induced BBB opening. |
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| 16677106 | Mele J, Van Remmen H, Vijg J, Richardson A: Characterization of transgenic mice that overexpress both zinc superoxide dismutase and catalase. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):628-38. The murine embryonic fibroblasts (MEFs) from the Tg (SOD1/CAT) +/o and MEFs overexpressing Cu/ZnSOD were more resistant to paraquat cytotoxicity, relative to wild-type MEFs. |
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| 12054598 | Joguchi A, Otsuka I, Minagawa S, Suzuki T, Fujii M, Ayusawa D: Overexpression of VDUP1 mRNA sensitizes HeLa cells to paraquat. . Biochem Biophys Res Commun. 2002 Apr 26;293(1):293-7. Their superoxide dismutase activity was normal. |
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| 16404156 | Choi SH, Kim DW, Kim SY, An JJ, Lee SH, Choi HS, Sohn EJ, Hwang SI, Won MH, Kang TC, Kwon HJ, Kang JH, Cho SW, Park J, Eum WS, Choi SY: Transduced human chaperone for Cu,Zn-SOD (PEP-1-CCS) protects against neuronal cell death. Mol Cells. 2005 Dec 31;20(3):401-8. Cu,Zn-superoxide dismutase (SOD) is one of the major means by which cells counteract the deleterious effects of ROS. When PEP-1-CCS was added to the culture medium of neuronal cells, it rapidly entered the cells and protected them against paraquat-induced cell death. |
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| 20116453 | Farmen E, Olsvik PA, Berntssen MH, Hylland K, Tollefsen KE: Oxidative stress responses in rainbow trout (Oncorhynchus mykiss) hepatocytes exposed to pro-oxidants and a complex environmental sample. Comp Biochem Physiol C Toxicol Pharmacol. 2010 May;151(4):431-8. Epub 2010 Jan 28. The pro-oxidants CuSO (4) and paraquat were used as models for comparison to a complex environmental sample. Results following 6, 24, 48 and 96h exposure to different concentrations of these substances show cellular effects on intracellular ROS formation, levels and redox status, expression of the antioxidant enzymes superoxide dismutase, catalase, peroxidase, glutathione reductase, gamma-glutamyl- synthetase (GCS) and thioredoxin, as well as cytotoxicity parameters. |
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| 18235974 | Chen P, Li A, Zhang M, He M, Chen Z, Wu X, Zhao C, Wang S, Liang L: Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells. Acta Biochim Biophys Sin. 2008 Feb;40(2):125-32. In this study, we examined the neuroprotective effect of (III) meso-tetrakis (N,N'-diethylimidazolium) (MnTDM), a superoxide dismutase/catalase mimetic, on PQ-induced oxidative stress and apoptosis in 1RB3AN27 (N27) cells, a dopaminergic neuronal cell line. |
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| 11379772 | Sasaki N, Baba N, Matsuo M: Cytotoxicity of reactive species and related agents toward undifferentiated and differentiated rat phenochromocytoma PC12 cells. Biol Pharm Bull. 2001 May;24(5):515-9. These species and agents include peroxide, hydroperoxide (LOOH), tert-butyl hydroperoxide, paraquat, 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH), 2,2'-azobis (2,4-dimethylvaleronitrile) (AMVN), and a -xanthine oxidase system. The peroxidase activity level of the undifferentiated cells was 2-3 times higher than the differentiated cells, the catalase activity level also tended to be higher, the superoxide dismutase activity level was higher on -protein-quantity basis but lower on -cell-number basis, and the total and concentration levels were considerably higher. |
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| 10899872 | West NP, Jungnitz H, Fitter JT, McArthur JD, Guzman CA, Walker MJ: Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence. Infect Immun. 2000 Aug;68(8):4673-80. The activities of superoxide dismutase, urease, and acid phosphatase were unaffected in the PGM-deficient strain. |
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| 16452308 | Ohsawa T, Tsukahara K, Sato T, Ogura M: stress decreases expression of srfA through inhibition of transcription of the comQXP quorum-sensing locus in Bacillus subtilis. J Biochem. 2006 Feb;139(2):203-11. During the course of screening for competence-deficient mutants in the mutant collection constructed by the Japan Consortium of Bacillus Functional Genomics, a disruption mutant of sodA encoding superoxide dismutase was identified as a mutant with decreased transformation efficiency. Furthermore, an excess amount of induced by the addition of paraquat also resulted in a decrease in comQXP transcription. |
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| 19633237 | Jang YC, Perez VI, Song W, Lustgarten MS, Salmon AB, Mele J, Qi W, Liu Y, Liang H, Chaudhuri A, Ikeno Y, Epstein CJ, Van Remmen H, Richardson A: Overexpression of Mn superoxide dismutase does not increase life span in mice. Sheng Wu Gong Cheng Xue Bao. 2009 Aug;25(8):1144-50. Genetic manipulations of Mn superoxide dismutase (MnSOD), SOD2 expression have demonstrated that altering the level of MnSOD activity is critical for cellular function and life span in invertebrates. Our data show that an approximately twofold overexpression of MnSOD throughout life in mice resulted in decreased lipid peroxidation, increased resistance against paraquat-induced oxidative stress, and decreased age-related decline in mitochondrial ATP production. |
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| 15451062 | Senator A, Rachidi W, Lehmann S, Favier A, Benboubetra M: Prion protein protects against DNA damage induced by paraquat in cultured cells. Free Radic Biol Med. 2004 Oct 15;37(8):1224-30. Our findings clearly show that PrPC overexpression plays a protective role against paraquat toxicity, probably by virtue of its superoxide dismutase-like activity. |
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| 16730205 | Choi YS, Lee KS, Yoon HJ, Kim I, Sohn HD, Jin BR: Bombus ignitus Cu,Zn superoxide dismutase (SOD1): cDNA cloning, gene structure, and up-regulation in response to paraquat, temperature stress, or lipopolysaccharide stimulation. Arch Microbiol. 2010 Mar;192(3):221-8. Epub 2010 Feb 4. |
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| 12180188 | Noriega GO, Gonzales S, Tomaro ML, Batlle AM: Paraquat-generated oxidative stress in rat liver induces heme oxygenase-1 and synthase. Free Radic Res. 2002 Jun;36(6):633-9. The activity of liver antioxidant enzymes, superoxide dismutase, catalase and peroxidase was decreased 3 h after paraquat injection. |
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| 12023089 | Roux M, Coves J: The iron-containing superoxide dismutase of Ralstonia metallidurans CH34. FEMS Microbiol Lett. 2002 Apr 23;210(1):129-33. The protein was 2-fold overexpressed in the presence of selenite, zinc or paraquat. |
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| 11447191 | Poyart C, Pellegrini E, Gaillot O, Boumaila C, Baptista M, Trieu-Cuot P: Contribution of Mn-cofactored superoxide dismutase (SodA) to the virulence of Streptococcus agalactiae. Infect Immun. 2001 Aug;69(8):5098-106. The growth rates of these strains in standing cultures were comparable, but the sodA mutant was extremely susceptible to the oxidative stress generated by addition of paraquat or peroxide to the culture medium and exhibited a higher mutation frequency in the presence of rifampin. |
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| 11414694 | Kernodle SP, Scandalios JG: Structural organization, regulation, and expression of the chloroplastic superoxide dismutase Sod1 gene in maize. Arch Biochem Biophys. 2001 Jul 1;391(1):137-47. Sod1 expression during development and in response to physiological and chemical stressors such as temperature, xenobiotics (paraquat), and light were examined. |
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| 11094160 | Kwon HY, Eum WS, Jang HW, Kang JH, Ryu J, Ryong Lee B, Jin LH, Park J, Choi SY: Transduction of Cu,Zn-superoxide dismutase mediated by an HIV-1 Tat protein basic domain into mammalian cells. FEBS Lett. 2000 Nov 24;485(2-3):163-7. The cell viability of HeLa cells treated with paraquat, an intracellular generator, was increased by transduced Tat-SOD. |
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| 12818794 | Kachadourian R, Flaherty MM, Crumbliss AL, Patel M, Day BJ: Synthesis and in vitro antioxidant properties of (III) beta-octabromo-meso-tetrakis (4-carboxyphenyl) J Inorg Biochem. 2003 Jul 1;95(4):240-8. The superoxide dismutase (SOD)-like activity of MnBr (8) TBAP (IC (50)=0.7 microM) was the same as (III) meso-tetrakis (N-methylpyridinium-4-yl) (MnTM-4-PyP (5+)), while the metal-centered redox potential of the first was considerably higher than the second (E (1/2)=+128 and 0 mV vs. normal electrode, respectively). The enhanced ability of MnBr (8) TBAP to inhibit paraquat- and hypoxia-induced injuries in vitro is also reported. |
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| 17997885 | Ma YT, Tian YP, Shi HW, Lv CH, Liu JH, Sun ZP: [Effects of high dose ambroxol on lung injury induced by paraquat in rats] . Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007 Sep;25(9):523-6. The arterial gas was determined and the extent of lung injury was assessed by measuring the ratio of wet to dry weight (W/D) and protein content in BALF, the WBC count, the percentage of PMN, the content of malondialdehyde (MDA) and the levels of superoxide dismutase (SOD) in the blood and BALF respectively. |
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| 12081532 | Mittova V, Tal M, Volokita M, Guy M: Salt stress induces up-regulation of an efficient chloroplast antioxidant system in the salt-tolerant wild tomato species Lycopersicon pennellii but not in the cultivated species. Physiol Plant. 2002 Jul;115(3):393-400. Further support for the above idea was supplied by leaf discs experiments in which pre-exposure of Lpa plants to salt-treatment conferred cross-tolerance to paraquat-induced oxidative stress while increased oxidative damage by paraquat-treatment was found in salt-stressed Lem plants. Increased activities of total superoxide dismutase (SOD), peroxidase (APX), monodehydroascorbate reductase (MDHAR), glutathione-S-transferase (GST), phospholipid hydroperoxide peroxidase (PHGPX) and several isoforms of non-specific peroxidases (POD) were found in chloroplasts of salt-treated Lpa plants. |
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| 17268803 | Lee YP, Kim SH, Bang JW, Lee HS, Kwak SS, Kwon SY: Enhanced tolerance to oxidative stress in transgenic tobacco plants expressing three antioxidant enzymes in chloroplasts. Plant Cell Rep. 2007 May;26(5):591-8. Epub 2007 Feb 1. The effect of simultaneous expression of genes encoding three antioxidant enzymes, zinc superoxide dismutase (CuZnSOD, EC 1.15.1.1), peroxidase (APX, EC 1.11.1.11), and (DHA) reductase (DHAR, EC 1.8.5.1), in the chloroplasts of tobacco plants was investigated under oxidative stress conditions. In previous studies, transgenic tobacco plants expressing both CuZnSOD and APX in chloroplast (CA plants), or DHAR in chloroplast showed enhanced tolerance to oxidative stresses, such as paraquat and salt. |
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| 19059428 | Yen K, Patel HB, Lublin AL, Mobbs CV: SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold. Mech Ageing Dev. 2009 Mar;130(3):173-8. Epub 2008 Nov 19. Because superoxide dismutase (SOD) plays a central role in detoxifying radicals, we have examined the effects of mutational inactivation of each isoform of sod on normal lifespan and lifespan extension by dietary restriction (DR) or cold-/hypothermic-induced longevity (CHIL). We find no significant decrease in lifespan for control worms or worms undergoing DR when sod isoforms are knocked-out even though sod mutational inactivation produces hypersensitivity to paraquat. |
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| 16032370 | Oliveira MV, Albuquerque JA, Paixao AD, Guedes LS, Cabral AM: High blood pressure is one of the symptoms of paraquat-induced toxicity in rats. Arch Toxicol. 2005 Sep;79(9):515-8. Epub 2005 Jul 20. The LP was evaluated by monitoring thiobarbituric acid reactive substances (TBARS) in the kidneys, liver and lungs, and validated by including a group treated with an antioxidant, superoxide dismutase (CuZnSOD 50,000 IU/kg), in the study. |
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| 19562038 | Trudel S, Kelly M, Fritsch J, Nguyen-Khoa T, Therond P, Couturier M, Dadlez M, Debski J, Touqui L, Vallee B, Ollero M, Edelman A, Brouillard F: Peroxiredoxin 6 fails to limit phospholipid peroxidation in lung from Cftr-knockout mice subjected to oxidative challenge. PLoS One. 2009 Jun 29;4(6):e6075. The aim of the current study was to investigate the cellular levels of reactive species (ROS), oxidative damage and enzymatic antioxidant defenses in the lung of Cftr-knockout mice in basal conditions and as a response to oxidative insult.The results show that endogenous ROS and lipid peroxidation levels are higher in Cftr (-/-) lung when compared to wild-type (Cftr (+/+)) in basal conditions, despite a strong enzymatic antioxidant response involving superoxide dismutases, peroxidases and peroxiredoxin 6 (Prdx6). A dramatic increase in PL-OOH levels in Cftr (-/-) lung consecutive to in vivo oxidative challenge by paraquat (PQ) unmasks a susceptibility to phospholipid peroxidation. |
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| 15288509 | Taylor DM, Minotti S, Agar JN, Durham HD: Overexpression of metallothionein protects cultured motor neurons against oxidative stress, but not mutant Cu/Zn-superoxide dismutase toxicity. Neurotoxicology. 2004 Sep;25(5):779-92. MT-III expression was restricted to neurons and was unaffected by treatment with ZnCl (2), paraquat, or |
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| 10774745 | Choi CH, Kim HS, Kweon OS, Lee TB, You HJ, Rha HS, Jeong JH, Lim DY, Min YD, Kim MS, Chung MH: Reactive species-specific mechanisms of drug resistance in paraquat-resistant acute myelogenous leukemia sublines. Mol Cells. 2000 Feb 29;10(1):38-46. |
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| 11264896 | Tomita M, Okuyama T, Ishikawa T, Hidaka K, Nohno T: The role of in paraquat-induced cytotoxicity in the human A549 lung carcinoma cell line. Free Radic Res. 2001 Feb;34(2):193-202. |
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| 11098297 | Konstantinova SG, Russanov EM: Studies on paraquat-induced oxidative stress in rat liver. . Acta Physiol Pharmacol Bulg. 1999;24(4):107-11. |
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| 10990116 | Ariyama J, Shimada H, Aono M, Tsuchida H, Hirai KI: Propofol improves recovery from paraquat acute toxicity in vitro and in vivo. Intensive Care Med. 2000 Jul;26(7):981-7. INTERVENTIONS: Paraquat-treated (0.2 mM) A549 cells were incubated either with the antioxidative sedatives propofol (0-0.56 mM) or thiopental (0-2.0 mM), or the nonantioxidative sedatives diazepam (0-3.0 mM), midazolam (0-3.0 mM) and ketamine (0-9.0 mM), as well as the antioxidative drugs, trolox (0-2.0 mM), (0-4.4 mM), antioxidative-processed food (AOB; 0-1.0 mg/ml), superoxide dismutase (SOD; 0 and 3,000 U/ml) and ulinastatin (0 and 50,000 U/ml), for 48 h. |
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| 15465637 | Peixoto F, Vicente J, Madeira VM: A comparative study of plant and animal mitochondria exposed to paraquat reveals that peroxide is not related to the observed toxicity. Toxicol In Vitro. 2004 Dec;18(6):733-9. The levels of superoxide dismutase and glutathione reductase are concurrent with the different sensitivities to paraquat, with higher activities in plant mitochondria. |
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| 11413228 | Ciriolo MR, Aquilano K, De Martino A, Carri MT, Rotilio G: Differential role of and in S-nitrosoglutathione-mediated apoptosis: a rationale for mild forms of familial amyotrophic lateral sclerosis associated with less active Cu,Zn superoxide dismutase mutants. J Neurochem. 2001 Jun;77(6):1433-43. On the other hand, H46R cells were as sensitive as SH-SY5Y cells to puromycin-induced apoptosis; furthermore, they were more susceptible to apoptosis elicited by the -generating drug paraquat and to cell necrosis provoked by t-butyl hydroperoxide. |
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| 12018841 | Park J, Ryu J, Jin LH, Bahn JH, Kim JA, Yoon CS, Kim DW, Han KH, Eum WS, Kwon HY, Kang TC, Won MH, Kang JH, Cho SW, Choi SY: 9-polylysine protein transduction domain: enhanced penetration efficiency of superoxide dismutase into mammalian cells and skin. Mol Cells. 2002 Apr 30;13(2):202-8. The cell viability of the fibroblast cells that were treated with paraquat, an intracellular generator, was increased by the transduced Tat-SOD or 9Lys-SOD. |
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| 10571042 | Kim YC, Miller CD, Anderson AJ: Transcriptional regulation by iron of genes encoding iron- and manganese-superoxide dismutases from Pseudomonas putida. Gene. 1999 Oct 18;239(1):129-35. Pp sodA or sodB genes both restored aerobic growth, growth on paraquat, and growth on minimal medium to an Escherichia coli (Ec) mutant deficient in SOD activity. |
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| 10520155 | Ito-Kuwa S, Nakamura K, Aoki S, Osafune T, Vidotto V, Pienthaweechai K: Oxidative stress sensitivity and superoxide dismutase of a wild-type parent strain and a respiratory mutant of Candida albicans. Med Mycol. 1999 Oct;37(5):307-14. When their survival was examined on an agar medium containing an intracellular O2- generator, paraquat (PQ), the parent strain was selectively killed by increasing the PQ concentration. |
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| 19129474 | Tan SX, Teo M, Lam YT, Dawes IW, Perrone GG: Cu, Zn superoxide dismutase and (H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae. Mol Biol Cell. 2009 Mar;20(5):1493-508. Epub 2009 Jan 7. Prior adaptation of the hac1 mutant deficient in the unfolded protein response (UPR) to the -generating agent paraquat reduced cell death under ER stress. |
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| 10644010 | Morandini R, Boeynaems JM, Duhant X, Jacquemotte F, Kinnaert E, Ghanem G: SODs are involved in the regulation of ICAM-1 expression in human melanoma and endothelial cells. Cell Mol Biol (Noisy-le-grand). 1999 Nov;45(7):1053-63. The latter is inactivated by superoxide dismutase of which two forms exist: Cu/Zn-SOD (cytoplasmic) and Mn-SOD (mitochondrial). Our results show a 20-50% increase in both SOD activities when cells were exposed to TNF or to an oxidative stress produced by Paraquat (a generator of radicals), both in terms of enzymes activity (zymogram) and protein levels (Western blotting and ELISA). |
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| 18400258 | Kim J, Takahashi M, Shimizu T, Shirasawa T, Kajita M, Kanayama A, Miyamoto Y: Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans. Mech Ageing Dev. 2008 Jun;129(6):322-31. Epub 2008 Mar 2. We have shown that platinum nanoparticles (nano-Pt) are a superoxide dismutase (SOD)/catalase mimetic. Even when 0.4M paraquat was loaded exogenously, nano-Pt (0.1 and 0.5mM) and EUK-8 (0.5 and 5mM) were effective in rescuing worms. |
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| 18755596 | Ahsan N, Lee DG, Lee KW, Alam I, Lee SH, Bahk JD, Lee BH: -induced oxidative stress in rice leaves revealed by proteomic approach. Plant Physiol Biochem. 2008 Dec;46(12):1062-70. Epub 2008 Jul 19. Two-week-old rice leaves were subjected to or a reactive species (ROS) inducing herbicide paraquat, and total soluble proteins were extracted and analyzed by two-dimensional gel electrophoresis (2-DE) coupled with matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry (MS) analysis. An increased accumulation of antioxidant enzymes including peroxidase, glutathione S-transferase, thioredoxin h-type, nucleoside diphosphate kinase 1, peroxiredoxin and a superoxide dismutase [Cu-Zn] chloroplast precursor in the -treated sample suggests that a treatment possibly generates oxidative stress in plants. |
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| 15750345 | Kim DW, Eum WS, Jang SH, Kim SY, Choi HS, Choi SH, An JJ, Lee SH, Lee KS, Han K, Kang TC, Won MH, Kang JH, Kwon OS, Cho SW, Kim TY, Park J, Choi SY: Transduced Tat-SOD fusion protein protects against ischemic brain injury. . Mol Cells. 2005 Feb 28;19(1):88-96. The antioxidant enzyme, Cu,Zn-superoxide dismutase (SOD), is one of the major means by which cells counteract the deleterious effects of ROS after ischemia. When Tat-SOD was added to the culture medium of neuronal cells, it rapidly entered the cells and protected them against paraquat-induced cell death. |
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| 14657410 | Fujibe T, Saji H, Arakawa K, Yabe N, Takeuchi Y, Yamamoto KT: A methyl viologen-resistant mutant of Arabidopsis, which is allelic to ozone-sensitive rcd1, is tolerant to supplemental ultraviolet-B irradiation. Plant Physiol. 2004 Jan;134(1):275-85. Epub 2003 Dec 4. Steady-state mRNA levels of plastidic Cu/Zn superoxide dismutase and stromal peroxidase were higher in rcd1-2 than in wild type, and the mRNA level of the latter enzyme was enhanced by UV-B exposure more effectively in rcd1-2. |
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| 15618434 | Tsukamoto S, Morita S, Hirano E, Yokoi H, Masumura T, Tanaka K: A novel cis-element that is responsive to oxidative stress regulates three antioxidant defense genes in rice. Plant Physiol. 2005 Jan;137(1):317-27. Epub 2004 Dec 23. In this study, we found that a 28-bp motif is conserved on the promoter regions of three antioxidant defense genes in rice (Oryza sativa): cytosolic superoxide dismutase (sodCc1), cytosolic thioredoxin (trxh), and glutaredoxin (grx). |
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| 14713163 | Lederer B, Boger P: Antioxidative responses of tobacco expressing a bacterial glutathione reductase. Z Naturforsch C. 2003 Nov-Dec;58(11-12):843-9. In contrast to the wild type, the transgenic tobacco suffered lipid peroxidation under moderate light intensities, while it was found to be more resistant towards oxidative stress induced by paraquat or peroxide. Transcript levels for deepoxidase and cytosolic Cu-Zn-superoxide dismutase were strongly reduced in BelW3gor plants as compared to BelW3. |
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| 15813218 | Durmus N, Kadioglu A: Reduction of paraquat toxicity in maize leaves by benzyladenine. Acta Biol Hung. 2005;56(1-2):97-107. |
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| 15530657 | Chen L, Rio DC, Haddad GG, Ma E: Regulatory role of dADAR in ROS metabolism in Drosophila CNS. Brain Res Mol Brain Res. 2004 Nov 24;131(1-2):93-100. Recently, we found that the mutant flies were very resistant to paraquat, a compound that generates free radicals. |
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| 17196654 | Cochon AC, Della Penna AB, Kristoff G, Piol MN, San Martin de Viale LC, Verrengia Guerrero NR: Differential effects of paraquat on oxidative stress parameters and polyamine levels in two freshwater invertebrates. Ecotoxicol Environ Saf. 2007 Oct;68(2):286-92. Epub 2006 Dec 29. The aim of this work was to investigate some aspects related to paraquat-induction of oxidative stress (lipoperoxidation, enzymatic activities of catalase and superoxide dismutase) and also the levels of polyamines and in two species of freshwater invertebrates, the oligochaete Lumbriculus variegatus and the gastropod Biomphalaria glabrata. |
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| 10222585 | De Angelis M, Gobbetti M: Lactobacillus sanfranciscensis CB1: superoxide dismutase and metabolism. Appl Microbiol Biotechnol. 1999 Mar;51(3):358-63. The enzyme was insensitive to H2O2 treatment, was not induced by the presence of paraquat under aerobic conditions and was relatively stable at pH 4.0. |
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| 19501168 | Lin CT, Tseng WC, Hsiao NW, Chang HH, Ken CF: Characterization, molecular modelling and developmental expression of zebrafish manganese superoxide dismutase. Fish Shellfish Immunol. 2009 Aug;27(2):318-24. Epub 2009 Jun 6. Real-time RT-PCR assay was used to detect the zMn-SOD mRNA expression during the developmental stages following a challenge with paraquat. |
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| 12876653 | Ken CF, Lin CT, Shaw JF, Wu JL: Characterization of fish Cu/Zn-superoxide dismutase and its protection from oxidative stress. Mar Biotechnol. 2003 Mar-Apr;5(2):167-73. In addition, the recombinant ZSOD was used to protect fish from 100 ppm of paraquat-induced oxidative injury by soaking fish larva in 55 micro g/ml SOD enzyme. |
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| 19000009 | Patel RM, van Kan JA, Bailey AM, Foster GD: RNA-mediated gene silencing of superoxide dismutase (bcsod1) in Botrytis cinerea. Phytopathology. 2008 Dec;98(12):1334-9. Plate-based assays with and without paraquat were performed to screen initial silencing efficiency, and a subset of transformants was used for in planta studies of virulence. |
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| 10036768 | Yoo HY, Kim SS, Rho HM: Overexpression and simple purification of human superoxide dismutase (SOD1) in yeast and its resistance to oxidative stress. J Biotechnol. 1999 Feb 5;68(1):29-35. The yeast overexpressing hSOD1 appeared to be more resistant to oxidative stresses such as paraquat, and heat shock. |
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| 20039174 | Fischer LR, Glass JD: Oxidative stress induced by loss of Cu,Zn-superoxide dismutase (SOD1) or -generating herbicides causes axonal degeneration in mouse DRG cultures. Acta Neuropathol. 2010 Feb;119(2):249-59. Epub 2009 Dec 29. To test susceptibility to increased production, we exposed wild-type DRGs to the redox-cycling herbicides paraquat and diquat (DQ). |
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| 11134328 | Borghouts C, Werner A, Elthon T, Osiewacz HD: -modulated gene expression and senescence in the filamentous fungus Podospora anserina. Mol Cell Biol. 2001 Jan;21(2):390-9. also controls transcript levels of PaSod2, the gene encoding the mitochondrial manganese superoxide dismutase (PaSOD2). |
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| 11154047 | Kim JS, Na CS, Pak SC, Kim YG: Effects of yukmi, an herbal formula, on the liver of senescence accelerated mice (SAM) exposed to oxidative stress. Am J Chin Med. 2000;28(3-4):343-50. The effects of yukmi (Decoction of six plants including rehmannia), an herbal formula, were studied on liver oxidant damage induced by paraquat (PQ) administered intravenously in the senescence accelerated mice (SAM-P/8). The activities of superoxide dismutase (SOD) and catalase as two major antioxidant enzymes and lipid peroxidation levels were determined for six days. |
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| 15058187 | Krasowska A, Dziadkowiec D, Lukaszewicz M, Wojtowicz K, Sigler K: Effect of antioxidants on Saccharomyces cerevisiae mutants deficient in superoxide dismutases. Folia Microbiol. 2003;48(6):754-60. The producer paraquat inhibited the aerobic growth of all three mutants in a concentration-dependent manner. |
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| 17928692 | Bando N, Wakamatsu S, Terao J: Effect of an excessive intake of on the level and antioxidative enzyme activities of mouse liver under paraquat-induced oxidative stress. Biosci Biotechnol Biochem. 2007 Oct;71(10):2569-72. Epub 2007 Oct 7. The same intake significantly increased the superoxide dismutase and peroxidase activities in the liver of both groups, indicating that excessive intake can either promote or attenuate oxidative stress in the liver. |
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| 12536259 | Lee HJ, Gu MB: Construction of a sodA::luxCDABE fusion Escherichia coli: comparison with a katG fusion strain through their responses to oxidative stresses. Appl Microbiol Biotechnol. 2003 Jan;60(5):577-80. Epub 2002 Dec 13. A recombinant bioluminescent Escherichia coli strain, EBHJ, (sodA::luxCDABE), containing the promoter for the manganese superoxide dismutase ( sodA) gene fused to the Vibrio fischeri luxCDABE operon, was successfully constructed and characterized. Redox-cycling agents, such as paraquat and strongly induced a sodA- regulated response in dose-dependent manners, resulting in an increase of the bioluminescence. |
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| 11557130 | Lehmann T, Kohler C, Weidauer E, Taege C, Foth H: Expression of MRP1 and related transporters in human lung cells in culture. Toxicology. 2001 Oct 5;167(1):59-72. AII cells exhibited low basal levels of mdr1b mRNA, that increased over time and after radical production induced by paraquat. mRNAs coding for antioxidative enzymes catalase (CAT), maganese superoxide dismutase (Mn-SOD) and /zinc superoxide dismutase (Cu/Zn-SOD) were not changed. |
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| 12422520 | Asma D, Yesilada O: Effect of paraquat on cellular defense enzymes and level of Funalia trogii. Folia Microbiol. 2002;47(4):413-6. |
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| 11762696 | Si ML, Al-Sharafi B, Lai CC, Khardori R, Chang C, Su CY: Gender difference in cytoprotection induced by on female and male bovine aortic endothelial cells. Endocrine. 2001 Aug;15(3):255-62. Bovine aortic endothelial cells from both genders were preconditioned for 24 h with E2 (1 nM to 10 microM), and their resistance to paraquat (1 mM, 3 h), a generator, was measured using an MTT assay. |
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| 15077630 | Ananieva EA, Christov KN, Popova LP: Exogenous treatment with leads to increased antioxidant capacity in leaves of barley plants exposed to paraquat. J Plant Physiol. 2004 Mar;161(3):319-28. To further define the role of SA in paraquat induced responses, we analysed the capacity of the antioxidative defence system by measuring the activities of several antioxidative enzymes: superoxide dismutase (SOD, EC 1.15.1.1), peroxidase (APX, EC 1.11.1.11), glutathione reductase (GR, EC 1.6.4.2), reductase (DHAR, EC 1.8.5.1), catalase (CAT, EC 1.11.1.6), and peroxidase (POX, EC 1.11.1.7). |
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| 19272249 | Zhu QH, Huang JX, Meng CS, Wang ML, Chen W, Zhang X: [Experimental study on therapeutic efficacy of tetrandrine on lung injury induced by acute of paraquat poisoning]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008 Oct;26(10):583-7. Levels of maleic dialdehyde (MDA), activities of superoxide dismutase (SOD) and peroxidase (GSH-Px) in plasma and the lung homogenate of three groups were determined at 3 d, 7 d, 14 d and 21 d after exposure to paraquat. |
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| 10768978 | Yesilkaya H, Kadioglu A, Gingles N, Alexander JE, Mitchell TJ, Andrew PW: Role of manganese-containing superoxide dismutase in oxidative stress and virulence of Streptococcus pneumoniae. Infect Immun. 2000 May;68(5):2819-26. Aerobically, D39HY1 had a lower growth rate than the wild type and exhibited susceptibility to the redox-active compound paraquat, but anaerobic growth of D39HY1 was identical to that of the wild type. |
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| 17712041 | Shuvaev VV, Tliba S, Nakada M, Albelda SM, Muzykantov VR: Platelet-endothelial cell adhesion molecule-1-directed endothelial targeting of superoxide dismutase alleviates oxidative stress caused by either extracellular or intracellular J Pharmacol Exp Ther. 2007 Nov;323(2):450-7. Epub 2007 Aug 21. In the second model, anti-PECAM/SOD at the optimal dose provided complete protection against necrosis caused by paraquat-induced intracellular generation. |
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| 11165630 | Schwanz P, Polle A: Growth under elevated CO (2) ameliorates defenses against photo-oxidative stress in poplar (Populus alba x tremula). Environ Exp Bot. 2001 Feb;45(1):43-53. To test the hypothesis that growth-CO (2) concentrations affect stress susceptibility, leaves of poplar trees (Populus alba x tremula) grown under ambient or about twofold ambient CO (2) concentrations were subjected to chilling temperatures at high light intensities or were exposed to paraquat. The protection was accompanied by rapid induction of superoxide dismutase activities (EC 1.15.1.1). |
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| 17549562 | Ken CF, Lin CT, Wen YD, Wu JL: Replacement of buried from zebrafish Cu/Zn superoxide dismutase and enhancement of its stability via site-directed mutagenesis. Mar Biotechnol. 2007 May-Jun;9(3):335-42. Epub 2007 Feb 15. In addition, we soaked fish larva with equal enzyme units of either ZSOD1 or ZSODC7A for 2 h, and then stressed them with 100 ppm of paraquat to induce oxidative injury. |
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| 20080171 | Zintel S, Schwitalla D, Luce K, Hamann A, Osiewacz HD: Increasing mitochondrial superoxide dismutase abundance leads to impairments in protein quality control and ROS scavenging systems and to lifespan shortening. Exp Gerontol. 2010 Jan 18. Over-expression of PaSod3 leads to lifespan reduction and increased sensitivity against paraquat and peroxide. |
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| 17416982 | Li JR, Yu P: Expression of Cu, Zn-superoxide dismutase gene from Saccharomyces cerevisiae in Pichia pastoris and its resistance to oxidative stress. Appl Biochem Biotechnol. 2007 Jan;136(1):127-39. The yeast overexpressing Cu, Zn- SOD appeared to be more resistant to oxidative stress such as paraquat, and heat shock. |
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| 20095325 | Huang M, Zhang P, Chang XL, Wu Q, Zhou ZJ: [Change of oxidative stress and nuclear factor-kappa B in acute paraquat poisoned rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009 Aug;27(8):457-62. On the 1st, the 3rd, the 7th, the 14th, the 28th and the 56th day after treatment, the level of malondialdehyde (MDA), the activity of peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and myeloperoxidase (MPO) in serum were detected; the content of (Hyp) and the activity of NF-kappaB in lung tissues were detected; the lung pathological changes of rats were observed. |
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| 11178967 | Kim HS, Lee TB, Choi CH: Down-regulation of catalase gene expression in the doxorubicin-resistant AML subline AML-2/DX100. Biochem Biophys Res Commun. 2001 Feb 16;281(1):109-14. The AML-2/DX100 also showed various levels of resistance to daunorubicin and vincristine but was paradoxically sensitive to peroxide (5-fold), t-butyl hydroperoxide (3-fold), and paraquat (2-fold) when compared to the drug-sensitive parental AML-2 cells (AML-2/WT). We compared the activities of antioxidant enzymes to detoxify reactive species (ROS), including superoxide dismutases, glutathione S-transferase, catalase, glutathione reductase, peroxidase, and glucose-6-phosphate dehydrogenase in both AML-2/WT and AML-2/DX100. |
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| 14570235 | Samper E, Nicholls DG, Melov S: Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts. Aging Cell. 2003 Oct;2(5):277-85. It is well established that exogenous oxidative stress and high doses of mitochondrial poisons such as paraquat and carbonyl 4 (trifluoromethoxy) phenylhydrazone (FCCP) can lead to genomic instability. We show that lack of mitochondrial superoxide dismutase in MEFs leads to a severe increase of double strand breaks, end-to-end fusions, chromosomal translocations, and loss of cell viability and proliferative capacity. |
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| 11854257 | Tseng HJ, McEwan AG, Paton JC, Jennings MP: Virulence of Streptococcus pneumoniae: PsaA mutants are hypersensitive to oxidative stress. Infect Immun. 2002 Mar;70(3):1635-9. Our investigations revealed altered expression of the key oxidative-stress response enzymes superoxide dismutase and oxidase in psaA and psaD mutants, suggesting that PsaA and PsaD may play important roles in the regulation of expression of oxidative-stress response enzymes and intracellular redox homeostasis. |
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| 18776016 | Branco R, Chung AP, Johnston T, Gurel V, Morais P, Zhitkovich A: The chromate-inducible chrBACF operon from the transposable element TnOtChr confers resistance to (VI) and J Bacteriol. 2008 Nov;190(21):6996-7003. Epub 2008 Sep 5. Expression of chrB, chrC, or chrF in an Escherichia coli sodA sodB double mutant restored its aerobic growth in minimal medium and conferred resistance to -generating agents and paraquat. Nitroblue tetrazolium staining on native gels showed that ChrC protein had superoxide dismutase activity. |
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| 17935786 | Olesen BT, Clausen J, Vang O: Characterization of the transcriptional profile in primary astrocytes after oxidative stress induced by Paraquat. Neurotoxicology. 2008 Jan;29(1):13-21. Epub 2007 Sep 1. This was done by investigating the time-dependent expression of selected genes encoding the antioxidative enzymes Mn- and CuZn superoxide dismutase (SOD) and catalase as well as the transcription factor component AP-1. |
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| 17360071 | Lee SH, Ahsan N, Lee KW, Kim DH, Lee DG, Kwak SS, Kwon SY, Kim TH, Lee BH: Simultaneous overexpression of both CuZn superoxide dismutase and peroxidase in transgenic tall fescue plants confers increased tolerance to a wide range of abiotic stresses. J Plant Physiol. 2007 Dec;164(12):1626-38. Epub 2007 Mar 13. |
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| 11743959 | Shin CY, Choi JW, Jang ES, Ju C, Kim WK, Kim HC, Choi CR, Ko KH: inhibits the death of immunostimulated rat C6 glioma cells deprived of Brain Res. 2001 Dec 20;922(2):267-75. In addition, a generator paraquat reversed the protective effect of on the augmented death. Superoxide dismutase (SOD) and the synthetic SOD mimetic Mn (III) tetrakis (4- inhibited the death of -deprived immunostimulated C6 glioma cells. |
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| 15487314 | Okamoto Y, Aoki S, Mataga I: Enhancement of amphotericin B activity against Candida albicans by Mycopathologia. 2004 Jul;158(1):9-15. This study aimed to examine the involvement of oxidative damage in amphotericin B (AmB) activity against Candida albicans using the (O2-) generator paraquat (PQ). |
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| 15177642 | Weidauer E, Lehmann T, Ramisch A, Rohrdanz E, Foth H: Response of rat alveolar type II cells and human lung tumor cells towards oxidative stress induced by peroxide and paraquat. Toxicol Lett. 2004 Jun 15;151(1):69-78. |
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| 12559405 | Houthoofd K, Braeckman BP, Lenaerts I, Brys K, De Vreese A, Van Eygen S, Vanfleteren JR: No reduction of metabolic rate in food restricted Caenorhabditis elegans. Exp Gerontol. 2002 Dec;37(12):1359-69. The specific activity levels of the antioxidant enzymes superoxide dismutase (SOD) and catalase showed small increases when we reduced food in wild-type worms, but restricted worms acquired no elevated protection against paraquat and peroxide. eat-2 mutants showed elevated specific activities of SOD and catalase relative to wild type in liquid culture. |
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| 19197346 | Van Raamsdonk JM, Hekimi S: Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 2009 Feb;5(2):e1000361. Epub 2009 Feb 6. In contrast to what is observed in other model organisms, none of the sod deletion mutants shows decreased lifespan compared to wild-type worms, despite a clear increase in sensitivity to paraquat- and juglone-induced oxidative stress. |
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| 20346072 | Yang W, Hekimi S: Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. Aging Cell. 2010 Mar 19. We have compared the phenotypes of nuo-6 (qm200) to those of nuo-6 (RNAi) and found them to be distinct in crucial ways, including patterns of growth and fertility, behavioral rates, consumption, ATP levels, autophagy, and resistance to paraquat, as well as expression of superoxide dismutases, mitochondrial heat shock proteins, and other gene expression markers. |
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| 11200086 | Bellaire BA, Carmody J, Braud J, Gossett DR, Banks SW, Lucas MC, Fowler TE: Involvement of abscisic acid-dependent and -independent pathways in the upregulation of antioxidant enzyme activity during NaCl stress in cotton callus tissue. Free Radic Res. 2000 Nov;33(5):531-45. Treatment with NaCl resulted in a rapid increase (within 30 minutes) in the ABA levels of the callus tissue, and the NaCl, ABA, and paraquat treatments induced rapid increases in the activities of superoxide dismutase, catalase, peroxidase, and glutathione reductase. |
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| 14744629 | Kim YG: Collaborative effects of Photobacterium CuZn superoxide dismutase (SODs) and human AP endonuclease in DNA repair and SOD-deficient Escherichia coli under oxidative stress. Free Radic Biol Med. 2004 Jan 15;36(2):173-9. The results show that survival rates were increased in sod+ xth- nfo+ cells compared with sod- xth- ape-, sod- xth- ape-, and sod+ xth- ape- cells under oxidative stress generated with 0.1 mM paraquat or 3 mM H2O2. |
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| 11581253 | Wei JP, Srinivasan C, Han H, Valentine JS, Gralla EB: Evidence for a novel role of -zinc superoxide dismutase in zinc metabolism. J Biol Chem. 2001 Nov 30;276(48):44798-803. Epub 2001 Oct 1. Here, we demonstrate certain phenotypic differences between these strains: 1) lys7Delta cells are slightly less sensitive to paraquat than sod1Delta cells, 2) EPR-detectable or "free" iron is dramatically elevated in sod1Delta mutants but not in lys7Delta yeast, and 3) although sod1Delta mutants show increased sensitivity to extracellular zinc, the lys7Delta strain is as resistant as wild type. |
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| 11895952 | Luke NR, Karalus RJ, Campagnari AA: Inactivation of the Moraxella catarrhalis superoxide dismutase SodA induces constitutive expression of iron-repressible outer membrane proteins. Infect Immun. 2002 Apr;70(4):1889-95. |
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| 10218660 | Tate DJ Jr, Miceli MV, Newsome DA: protects against oxidative damage in cultured human retinal pigment epithelial cells. Free Radic Biol Med. 1999 Mar;26(5-6):704-13. After 1 week, MTT assays were performed to determine the relative cytotoxicity of H2O2 or paraquat on RPE cells. The antioxidants metallothionein, catalase, superoxide dismutase, and peroxidase were also measured. |
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| 19784828 | Li H, Jubelirer S, Garcia Costas AM, Frigaard NU, Bryant DA: Multiple antioxidant proteins protect Chlorobaculum tepidum against and reactive species. Arch Microbiol. 2009 Nov;191(11):853-67. Epub 2009 Sep 27. The encoded proteins include cytochrome bd oxidase, oxidase, rubredoxin oxidoreductase, several thiol peroxidases, alkyl hydroperoxide reductase, superoxide dismutase, reductase, and rubrerythrin. |
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| 17325048 | Keith KE, Valvano MA: Characterization of SodC, a periplasmic superoxide dismutase from Burkholderia cenocepacia. Infect Immun. 2007 May;75(5):2451-60. Epub 2007 Feb 26. In this study, we identified the sodC gene encoding a Cu,ZnSOD in B. cenocepacia and demonstrated that a sodC null mutant was not sensitive to a H2O2, 3-morpholinosydnonimine, or paraquat challenge but was killed by exogenous generated by the /xanthine oxidase method. |
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| 16176138 | Lee J, Hwang KT, Heo MS, Lee JH, Park KY: Resistance of Lactobacillus plantarum KCTC 3099 from Kimchi to oxidative stress. J Med Food. 2005 Fall;8(3):299-304. To evaluate the resistance of the two lactic acid bacteria to ROS, we tested their survival in the presence of 1 mM peroxide, 0.4 mM and anions induced by 10 mM paraquat. To define the antioxidative mechanism, superoxide dismutase (SOD) and metal ion chelating activities were determined. |
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| 15870370 | Kim SY, Nishioka M, Hayashi S, Honda H, Kobayashi T, Taya M: The gene yggE functions in restoring physiological defects of Escherichia coli cultivated under oxidative stress conditions. Appl Environ Microbiol. 2005 May;71(5):2762-5. DNA microarray analysis showed that yfiD, yggB, and yggE genes were up-regulated when superoxide dismutase (SOD)-deficient Escherichia coli IM303 (I4) was cultivated under the oxidative stress generated by photoexcited TiO (2), and pYFD, pYGB, and pYGE were constructed by inserting the respective genes into a pUC 19 vector. In the culture of wild-type strain, E. coli MM294, in the medium with paraquat (10 micromol/l), maximum specific growth rate of the cells with pYGE was about five times higher than that of the control cells, with a decreased ROS content in the former cells. |
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| 15182862 | Van Remmen H, Qi W, Sabia M, Freeman G, Estlack L, Yang H, Mao Guo Z, Huang TT, Strong R, Lee S, Epstein CJ, Richardson A: Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic Biol Med. 2004 Jun 15;36(12):1625-34. To examine the effect of compound deficiencies in antioxidant defense, we have generated mice (Sod2 (+/-)/Gpx1 (-/-)) that are deficient in Mn superoxide dismutase (MnSOD) and glutathione peroxidase 1 (Gpx1) by breeding Sod2 (+/-) and Gpx1 (-/-) mice together. Whole-animal studies demonstrated that survival of the Sod2 (+/-)/Gpx1 (-/-) mice in response to whole body gamma irradiation or paraquat administration was also reduced compared with that of wild-type, Sod2 (+/-), or Gpx1 (-/-) mice. |
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| 19148671 | Jagadeeswaran G, Saini A, Sunkar R: Biotic and abiotic stress down-regulate miR398 expression in Arabidopsis. Planta. 2009 Mar;229(4):1009-14. Epub 2009 Jan 16. MicroRNA398 targets two Cu/Zn superoxide dismutases (CSD1 and CSD2) in higher plants. Previous investigations revealed both decreased miR398 expression during high Cu (2+) or paraquat stress and increased expression under low Cu (2+) or high in the growth medium. |
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| 10910079 | Siemankowski LM, Morreale J, Butts BD, Briehl MM: Increased tumor necrosis factor-alpha sensitivity of MCF-7 cells transfected with NAD (P) H:quinone reductase. Cancer Res. 2000 Jul 1;60(13):3638-44. This increased sensitivity could not be explained by changes in superoxide dismutase or catalase activity or to increased sensitivity to oxidative stress in general, as assessed by response to peroxide and paraquat treatment. |
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| 12732627 | Wang X, Phelan SA, Forsman-Semb K, Taylor EF, Petros C, Brown A, Lerner CP, Paigen B: Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. J Biol Chem. 2003 Jul 4;278(27):25179-90. Epub 2003 May 5. To determine these functions, we generated Prdx6-targeted mutant (Prdx6-/-) mice, confirmed the gene disruption by Southern blots, PCR, RT-PCR, Western blots, and immunohistochemistry, and compared the effects of paraquat, peroxide, and t-butyl hydroperoxide on Prdx6-/- and wild-type (Prdx6+/+) macrophages, and of paraquat on Prdx6-/- and Prdx6+/+ mice. |
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| 19634056 | Schriner SE, Abrahamyan A, Avanessian A, Bussel I, Maler S, Gazarian M, Holmbeck MA, Jafari M: Decreased mitochondrial levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea. Free Radic Res. 2009 Sep;43(9):836-43. Epub 2009 Jul 24. |
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| 16139868 | Tirosh O, Pardo M, Schwartz B, Miskin R: Long-lived alphaMUPA transgenic mice show reduced SOD2 expression, enhanced apoptosis and reduced susceptibility to the carcinogen dimethylhydrazine. Mech Ageing Dev. 2005 Dec;126(12):1262-73. Epub 2005 Sep 1. The SOD2-related parameters included the levels of SOD2 mRNA, immunoreactivity and enzymatic activity in the liver, lipid oxidation and aconitase activity in isolated liver mitochondria, and the sensitivity of the mice to paraquat, an agent that elicits oxidative stress. |
117(1,2,2,7) | Details |
| 15467288 | Nicotera TM, Ding D, McFadden SL, Salvemini D, Salvi R: Paraquat-induced hair cell damage and protection with the superoxide dismutase mimetic m40403. Audiol Neurootol. 2004 Nov-Dec;9(6):353-62. Epub 2004 Oct 1. M40403, a highly specific, nonpeptidyl mimetic of superoxide dismutase, was added to some cultures to inactivate the generated by paraquat. |
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| 12661985 | Jung IL, Kim IG: Polyamines reduce paraquat-induced soxS and its regulon expression in Escherichia coli. Cell Biol Toxicol. 2003 Feb;19(1):29-41. Glucose-6-phosphate dehydrogenase (G6PDH; encoded by zwf) and manganese-containing superoxide dismutase (Mn-SOD; encoded by sodA) activities induced by paraquat were decreased by exogenous polyamines. |
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| 19897052 | Mussi MA, Calcaterra NB: Paraquat-induced oxidative stress response during amphibian early embryonic development. Comp Biochem Physiol C Toxicol Pharmacol. 2010 Mar;151(2):240-7. Epub . Regarding detoxifying enzymes, a significant induction of Mn-superoxide dismutase activity was detected at stages beyond gastrula in embryos surviving Paraquat treatment, suggesting a major role of this enzyme in the antioxidant response during early embryonic development. |
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| 12972424 | Missirlis F, Hu J, Kirby K, Hilliker AJ, Rouault TA, Phillips JP: Compartment-specific protection of iron- proteins by superoxide dismutase. J Biol Chem. 2003 Nov 28;278(48):47365-9. Epub 2003 Sep 12. We also find that exposure of adults to paraquat converts cytosolic aconitase to IRP1 but has no affect on mitochondrial aconitase, indicating that paraquat generates in the cytosol but not in mitochondria. |
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| 10694572 | Wong PC, Waggoner D, Subramaniam JR, Tessarollo L, Bartnikas TB, Culotta VC, Price DL, Rothstein J, Gitlin JD: Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2886-91. Consistent with this loss of SOD1 activity, CCS (-/-) mice showed increased sensitivity to paraquat and reduced female fertility, phenotypes that are characteristic of SOD1-deficient mice. |
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| 10882731 | Srinivasan C, Liba A, Imlay JA, Valentine JS, Gralla EB: Yeast lacking superoxide dismutase (s) show elevated levels of "free iron" as measured by whole cell electron paramagnetic resonance. J Biol Chem. 2000 Sep 22;275(38):29187-92. In wild-type cells, an increase in the EPR-detectable iron pool could be induced by treatment with paraquat, a redox-cycling drug that generates |
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| 19770032 | Peng C, Chan HY, Li YM, Huang Y, Chen ZY: Black tea theaflavins extend the lifespan of fruit flies. Exp Gerontol. 2009 Dec;44(12):773-83. Epub 2009 Sep 19. Gene expression of superoxide dismutase (SOD1 and SOD2), catalase (CAT), and methuselah (MTH) was characterized by an increase in young and then a decrease in aged fruit flies. Paraquat and H (2) O (2) challenge tests demonstrated that BTE prolonged the survival time only for Oregon-R wild type flies but not for SOD (n108) or Cat (n1) mutants. |
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| 10705509 | Hirano T, Hirobe M, Kobayashi K, Odani A, Yamauchi O, Ohsawa M, Satow Y, Nagano T: Mechanism of superoxide dismutase-like activity of Fe (II) and Fe (III) complexes of tetrakis-N,N,N',N'(2-pyridylmethyl) ethylenediamine. Chem Pharm Bull. 2000 Feb;48(2):223-30. Chem., 264, 9243-9249 (1989)), we reported that this complex has a potent SOD activity in a cyt. c (cytochrome c)-based system (IC50 = 0.8 microM) and protects E. coli cells against paraquat toxicity. |
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| 11369509 | Rossi L, Marchese E, Lombardo MF, Rotilio G, Ciriolo MR: Increased susceptibility of -deficient neuroblastoma cells to oxidative stress-mediated apoptosis. Free Radic Biol Med. 2001 May 15;30(10):1177-87. Treatment of neuroblastoma cells with the chelator triethylene tetramine tetrahydrochloride induced intracellular decrease of content paralleled by diminished activity of the enzymes Cu, Zn superoxide dismutase, and cytochrome c oxidase. When -deficient cells were challenged with oxidative stress generated by paraquat or puromycin, they underwent a higher degree of apoptosis with respect to -adequate control cells. |
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| 18067869 | Samai M, Hague T, Naughton DP, Gard PR, Chatterjee PK: Reduction of paraquat-induced renal cytotoxicity by and complexes of EGTA and EHPG. Free Radic Biol Med. 2008 Feb 15;44(4):711-21. Epub 2007 Nov 13. Although superoxide dismutase mimetics (SODm) have provided protection against organ injury involving generation of anions, they often suffer problems, e.g., regarding their bioavailability or potential pro-oxidant activity. |
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| 14660625 | Park SY, Chang I, Kim JY, Kang SW, Park SH, Singh K, Lee MS: Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase. J Biol Chem. 2004 Feb 27;279(9):7512-20. Epub 2003 Dec 3. O (2)(.) contents increased during rho (0) cell derivation but became normalized after establishment of rho (0) phenotypes, suggesting that MnSOD induction is an adaptive process to increased O (2)(.). rho (0) cells were resistant to paraquat, or doxorubicin, and O (2)(.) contents after treatment with them were lower in rho (0) cells compared with parental cells because of MnSOD overexpression. |
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| 10613858 | Pomposiello PJ, Demple B: Identification of SoxS-regulated genes in Salmonella enterica serovar typhimurium. J Bacteriol. 2000 Jan;182(1):23-9. This system was used to demonstrate that soxS expression is sufficient for the induction of resistance to the -generating drug paraquat and for the transcriptional activation of the sodA and micF genes. Nucleotide sequence determination identified the disrupted genes as sodA (Mn-containing superoxide dismutase), fpr (NADPH:ferredoxin oxidoreductase), and ydbK (a putative Fe-S-containing reductase). |
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| 15926316 | Ezhova TA, Soldatova OP, Mamanova LB, Musin SM, Grimm B, Shestakov SV: [Collection of Arabidopsis thaliana mutants with altered sensitivity to oxidative stress inductors]. Izv Akad Nauk Ser Biol. 2001 Sep-Oct;(5):533-43. Genetic and biochemical analysis of certain mutants was performed; quantitative and qualitative changes in the content of superoxide dismutase and peroxidase isoforms have been revealed. These data, complemented by the data on the cross-tolerance (sensitivity) of the mutants to paraquat, indicate a correlation between tolerance to the OS inductors and the functions of antioxidant systems. |
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| 14520962 | Gessler NN, Sokolov AV, Belozerskaia TA: [Participation of in antioxidant defense of bacterial cells] . Prikl Biokhim Mikrobiol. 2003 Jul-Aug;39(4):435-7. The effect of recombinant on the resistance of E. coli culture to and paraquat was studied. |
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| 18057120 | White CN, Hamilton EJ, Garcia A, Wang D, Chia KK, Figtree GA, Rasmussen HH: Opposing effects of coupled and uncoupled NOS activity on the Na+-K+ pump in cardiac myocytes. Am J Physiol Cell Physiol. 2008 Feb;294(2):C572-8. Epub 2007 Dec 5. The paraquat-induced pump inhibition was abolished by superoxide dismutase (in pipette solutions). |
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| 15159446 | Osakada F, Kawato Y, Kume T, Katsuki H, Sugimoto H, Akaike A: Serofendic acid, a -containing diterpenoid derived from fetal calf serum, attenuates reactive species-induced oxidative stress in cultured striatal neurons. J Pharmacol Exp Ther. 2004 Oct;311(1):51-9. Epub 2004 May 24. Paraquat caused neuronal death, which was inhibited by a cell-permeable superoxide dismutase (SOD) mimetic, Mn (III) tetrakis (4- (Mn-TBAP); a cell-permeable SOD/catalase mimetic, EUK-134 3-methoxy N,N'-bis (salicylidene) ethylenediamine and a ferrous ion chelator, 2,2'-dipyridyl, in rat striatal cultures. |
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| 15946937 | Peng J, Stevenson FF, Doctrow SR, Andersen JK: Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson disease. J Biol Chem. 2005 Aug 12;280(32):29194-8. Epub 2005 Jun 9. |
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| 15907763 | Barata C, Varo I, Navarro JC, Arun S, Porte C: Antioxidant enzyme activities and lipid peroxidation in the freshwater cladoceran Daphnia magna exposed to redox cycling compounds. Comp Biochem Physiol C Toxicol Pharmacol. 2005 Feb;140(2):175-86. Epub 2005 Feb 24. Activities of key antioxidant enzymes including catalase, superoxide dismutase, peroxidase and glutathione S-transferases and levels of lipid peroxidation measured as thiobarbituric acid-reactive substances (TBARS) and lipofucsin pigment content were determined in D. magna juveniles after being exposed to sublethal levels of paraquat, endosulfan, cadmium and for 48 h. |
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| 15093102 | Patra J, Panda BB: A comparison of biochemical responses to oxidative and metal stress in seedlings of barley, Hordeum vulgare L. Environ Pollut. 1998;101(1):99-105. Biochemical responses on the bases of activities of antioxidant enzymes; peroxidase, catalase, superoxide dismutase and glutathione reductase as well as estimations of total protein, lipid peroxidation and thiols in the form of protein, non-protein, and phytochelatin measured in growing seedlings of barley, Hordeum vulgare L., from Day 2 through 8 were compared following treatment of seeds for 2 h with oxidative agents, paraquat 5 x 10 (-5), 10 (-4), 10 (-3) M, H2O2 10 (-3), 5 x 10 (-3), 10 (-2) M and a metal salt, CdSO4 10 (-5), 10 (-4), 10 (-3) M. |
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| 12470895 | Yanase S, Yasuda K, Ishii N: Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span. Mech Ageing Dev. 2002 Nov;123(12):1579-87. We found that daily short-term exposure (3 h) to hyperoxia further extended the life span of age-1, a phenomenon known as an adaptive response. age-1 also showed resistance to paraquat and heat. We measured mRNA levels of superoxide dismutase genes (sod-1 through 4), catalase genes (clt-1 and ctl-2), known to encode anti-oxidant enzymes, and found they were elevated in age-1 young adults. |
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| 12018858 | Eum WS, Choung IS, Kim AY, Lee YJ, Kang JH, Park J, Lee KS, Kwon HY, Choi SY: Transduction efficacy of Tat-Cu,Zn-superoxide dismutase is enhanced by recovery of the fusion protein. Mol Cells. 2002 Apr 30;13(2):334-40. With the higher transduction efficacy of CR-Tat-SOD than that of Tat-SOD, the transduced CR-Tat-SOD significantly increased the viability of HeLa cells that were pretreated with paraquat, an intracellular generator. |
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| 10969820 | Pani G, Bedogni B, Anzevino R, Colavitti R, Palazzotti B, Borrello S, Galeotti T: Deregulated manganese superoxide dismutase expression and resistance to oxidative injury in p53-deficient cells. Cancer Res. 2000 Aug 15;60(16):4654-60. |
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| 11457901 | Abarca D, Roldan M, Martin M, Sabater B: Arabidopsis thaliana ecotype Cvi shows an increased tolerance to photo-oxidative stress and contains a new chloroplastic /zinc superoxide dismutase isoenzyme. J Exp Bot. 2001 Jul;52(360):1417-25. Paraquat treatments of A. thaliana ecotypes Ler and Cvi resulted in higher levels of chloroplastic Cu/Zn-SOD activity in Cvi, suggesting that the Cvi isoenzyme has a higher stability and/or turnover rate than the Ler variant under photo-oxidative conditions. |
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| 11526011 | Barriere C, Bruckner R, Talon R: Characterization of the single superoxide dismutase of Staphylococcus xylosus. Appl Environ Microbiol. 2001 Sep;67(9):4096-104. The sod expression was not affected by and increased slightly with paraquat. |
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| 20089839 | Zubovych IO, Straud S, Roth MG: Mitochondrial dysfunction confers resistance to multiple drugs in Caenorhabditis elegans. Mol Biol Cell. 2010 Mar;21(6):956-69. Epub 2010 Jan 20. Respiratory complex inhibitors, FCCP and oligomycin, and a producer of reactive species (ROS), paraquat, all rescued wild-type worms from hemiasterlin toxicity. Worms lacking mitochondrial superoxide dismutase (MnSOD) were modestly drug-resistant, and elimination of MnSOD in the phb-2, har-1, and spg-7 mutants enhanced resistance. |
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| 17927963 | Seong ES, Cho HS, Choi D, Joung YH, Lim CK, Hur JH, Wang MH: Tomato plants overexpressing CaKR1 enhanced tolerance to salt and oxidative stress. Biochem Biophys Res Commun. 2007 Nov 30;363(4):983-8. Epub 2007 Oct 2. In particular, transgenic plants produced higher levels of transcripts encoding the pathogenesis-related (PR) proteins LePR1, LePR2, and LePR3, as well as oxidative stress response proteins, such as superoxide dismutase (LeSOD2) and peroxidase (LeAPX2 and LeAPX3). |
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| 11590119 | Oeda T, Shimohama S, Kitagawa N, Kohno R, Imura T, Shibasaki H, Ishii N: Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans. Hum Mol Genet. 2001 Sep 15;10(19):2013-23. Mutations in the Cu/Zn superoxide dismutase (SOD1) genes are present in approximately 20% of families suffering from familial amyotrophic lateral sclerosis (FALS). The transgenic strains expressing mutant human SOD1 showed greater vulnerability to oxidative stress induced by 0.2 mM paraquat than a control that contained the wild-type human SOD1. |
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| 15659779 | Chun YS, Yeo EJ, Suh HJ, Park JW: Spontaneous generation of reactive species in the mixture of and Ann N Y Acad Sci. 2004 Dec;1030:43-51. In assaying prooxidant or antioxidant activities, has been commonly used as an inhibitor of mitochondrial oxidases, peroxidases, or Cu,Zn-superoxide dismutase, which have an influence on intracellular levels of reactive species. |
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| 16936100 | Schlieve CR, Lieven CJ, Levin LA: Biochemical activity of reactive species scavengers do not predict retinal ganglion cell survival. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3878-86. Last, H2O2 induced intramitochondrial O2-, whereas paraquat produced O2- outside of the mitochondria, and these areas of generation can mislead interpretations of ROS scavenger activity and effectiveness. Scavengers tested were catalase, polyethylene glycol-superoxide dismutase (PEG-SOD), (III) tetrakis (1-methyl-4-pyridyl) (MnTMPyP), 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox), deferoxamine, and U-74389G. |
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| 19286803 | Ballal A, Manna AC: Regulation of superoxide dismutase (sod) genes by SarA in Staphylococcus aureus. J Bacteriol. 2009 May;191(10):3301-10. Epub 2009 Mar 13. |
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| 10844693 | Kehres DG, Zaharik ML, Finlay BB, Maguire ME: The NRAMP proteins of Salmonella typhimurium and Escherichia coli are selective transporters involved in the response to reactive Mol Microbiol. 2000 Jun;36(5):1085-100. In both S. typhimurium and E. coli, mntH:lacZ constructs were strongly induced by peroxide, weakly induced by EDTA and unresponsive to paraquat, consistent with the presence of Fur and OxyR binding sites in the promoters. |
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| 19135146 | James BP, Staatz WD, Wilkinson ST, Meuillet E, Powis G: Superoxide dismutase is regulated by LAMMER kinase in Drosophila and human cells. Free Radic Biol Med. 2009 Mar 15;46(6):821-7. Epub 2008 Dec 24. We have shown that mutations in the Drosophila LAMMER kinase gene, Darkener of apricot (Doa), protect against the decrease in life span caused by the reactive species (ROS) generator paraquat, and at the same time show an increase in cytoplasmic (CuZn-Sod or SOD1) and mitochondrial superoxide dismutase (Mn-Sod or SOD2) protein levels and activity. |
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| 10446154 | Yoo HY, Chang MS, Rho HM: The activation of the rat /zinc superoxide dismutase gene by peroxide through the peroxide-responsive element and by paraquat and heat shock through the same heat shock element. J Biol Chem. 1999 Aug 20;274(34):23887-92. |
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| 10490279 | Tampo Y, Tsukamoto M, Yonaha M: production from paraquat evoked by exogenous in pulmonary endothelial cells. Free Radic Biol Med. 1999 Sep;27(5-6):588-95. Increased rates of production from paraquat, which were sensitive to superoxide dismutase (SOD), required the presence of in the reaction medium, and occurred instantaneously after the addition of which is impermeable to cell membranes. |
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| 12384824 | Hauck SJ, Aaron JM, Wright C, Kopchick JJ, Bartke A: Antioxidant enzymes, free-radical damage, and response to paraquat in liver and kidney of long-living growth hormone receptor/binding protein gene-disrupted mice. Horm Metab Res. 2002 Sep;34(9):481-6. We measured activities of antioxidant enzymes Cu/Zn superoxide dismutase (SOD), catalase (CAT), and peroxidase (GPx) and quantified free-radical damage by lipid peroxidation (LP) and protein oxidation (PO) measurements in liver and kidney tissues, and evaluated the response to paraquat-induced oxygen toxicity in the long-living GH receptor/binding protein gene knockout (GHR-KO) mouse. |
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| 14605796 | Li K, Pasternak C, Klug G: Expression of the trxA gene for thioredoxin 1 in Rhodobacter sphaeroides during oxidative stress. Arch Microbiol. 2003 Dec;180(6):484-9. Epub 2003 Nov 7. While the kinetics of increased trxA mRNA and of sodB mRNA, encoding superoxide dismutase, were similar after addition of tert-butyl hydroperoxide ( t-BOOH) or peroxide (H (2) O (2)), different kinetics were observed after addition of diamide or paraquat, indicating the involvement of different stress responses in the regulation of these genes. |
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| 18436336 | Peixoto FP, Gomes-Laranjo J, Vicente JA, Madeira VM: Comparative effects of the herbicides dicamba, 2,4-D and paraquat on non-green potato tuber calli. J Plant Physiol. 2008 Jul 31;165(11):1125-33. Epub 2008 Apr 23. Superoxide dismutase (SOD) activity was strongly stimulated by paraquat, whereas dicamba and 2,4-D were efficient only at higher concentrations. |
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| 19377883 | Qian H, Chen W, Sun L, Jin Y, Liu W, Fu Z: Inhibitory effects of paraquat on photosynthesis and the response to oxidative stress in Chlorella vulgaris. Ecotoxicology. 2009 Jul;18(5):537-43. Epub 2009 Apr 18. Exposure to 0.5 microM paraquat increased the activities of the antioxidant enzymes superoxide dismutase, peroxidase, and catalase to levels 4.93, 3.19, and 3.09 times higher, respectively, than those of the control. |
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| 12898709 | Hwang CS, Baek YU, Yim HS, Kang SO: Protective roles of mitochondrial manganese-containing superoxide dismutase against various stresses in Candida albicans. Yeast. 2003 Aug;20(11):929-41. |
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| 14641049 | Sampayo JN, Gill MS, Lithgow GJ: Oxidative stress and aging--the use of superoxide dismutase/catalase mimetics to extend lifespan. Biochem Soc Trans. 2003 Dec;31(Pt 6):1305-7. These compounds also appear to confer resistance to oxidative damage, since they protect against paraquat treatment. |
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| 17324120 | Agbas A, Hui D, Wang X, Tek V, Zaidi A, Michaelis EK: Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo. Biochem J. 2007 Jul 1;405(1):51-9. |
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| 12392545 | Hunter T, Bannister JV, Hunter GJ: Thermostability of - and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a residue. Eur J Biochem. 2002 Nov;269(21):5137-48. |
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| 14622980 | Andrus JM, Bowen SW, Klaenhammer TR, Hassan HM: Molecular characterization and functional analysis of the manganese-containing superoxide dismutase gene (sodA) from Streptococcus thermophilus AO54. Arch Biochem Biophys. 2003 Dec 1;420(1):103-13. The gene was expressed in Escherichia coli and was able to rescue the growth of a sodAsodB mutant in a minimal-medium containing 10 (-6) M paraquat. |
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| 20076970 | Li AH, Na BK, Ahn SK, Cho SH, Pak JH, Park YK, Kim TS: Functional expression and characterization of a cytosolic /zinc-superoxide dismutase of Spirometra erinacei. Parasitol Res. 2010 Feb;106(3):627-35. SeCuZnSOD was functionally expressed in both S. erinacei plerocercoid larvae and adult worms, and its expression level was significantly increased when the plerocercoid larvae were treated with paraquat. |
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| 17013634 | Tremaroli V, Fedi S, Zannoni D: Evidence for a tellurite-dependent generation of reactive species and absence of a tellurite-mediated adaptive response to oxidative stress in cells of Pseudomonas pseudoalcaligenes KF707. Arch Microbiol. 2007 Feb;187(2):127-35. Epub 2006 Sep 30. Cells treated with sub-lethal concentrations of TeO3 (2-) showed neither adaptation to it nor cross-protection against oxidants such as 1,1'-4,4'-bipyridinium dichloride (paraquat, PQ2+), diazenedicarboxylic acid bis-N,N-dimethylamide (diamide), tert-butyl hydroperoxide (tBH) and peroxide (H2O2). Tellurite was shown to decrease the cellular content of reduced thiols (RSH) with a consequent increase in the production of reactive species (ROS) and stimulation of the superoxide dismutase (SOD) activity. |
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| 18985485 | Ahmad I, Kumar A, Shukla S, Prasad Pandey H, Singh C: The involvement of in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes. Free Radic Res. 2008 Oct;42(10):849-62. A significant increase in myeloperoxidase (MPO), superoxide dismutase (SOD), iNOS expression and lipid peroxidation (LPO) was observed in PMNs of MB- and/or PQ-treated animals, while catalase and glutathione S-transferase (GST) activities were attenuated. |
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| 19542013 | Figtree GA, Liu CC, Bibert S, Hamilton EJ, Garcia A, White CN, Chia KK, Cornelius F, Geering K, Rasmussen HH: Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation. Circ Res. 2009 Jul 17;105(2):185-93. Epub 2009 Jun 18. We detected glutathionylation of beta (1), but not alpha (1), subunits in rabbit ventricular myocytes at baseline. beta (1) Subunit glutathionylation was increased by (ONOO (-)), paraquat, or activation of oxidase by Ang II. Glutathionylation was reversed after addition of superoxide dismutase. |
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| 11536143 | Bai Z, Harvey LM, McNeil B: Use of the chemiluminescent probe lucigenin to monitor the production of the radical in a recombinant Aspergillus niger (B1-D). Biotechnol Bioeng. 2001 Oct 20;75(2):204-11. Addition of pure and the redox cycling agent paraquat to fungal pellet suspensions resulted in a considerable increase in lucigenin-derived chemiluminescence (LDCL). In the presence of exogenous superoxide dismutase (SOD), the LDCL of a disrupted cell solution was inhibited. |
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| 12704140 | Janulczyk R, Ricci S, Bjorck L: MtsABC is important for and iron transport, oxidative stress resistance, and virulence of Streptococcus pyogenes. Infect Immun. 2003 May;71(5):2656-64. Using paraquat and peroxide to induce oxidative stress, we show that the mutant has an increased susceptibility to reactive species. Moreover, activity of the -cofactored superoxide dismutase in the mutant is reduced, probably as a consequence of reduced intracellular availability of |
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| 15552644 | Masui S, Majima T, Nakamura K, Ito-Kuwa S, Takeo K, Aoki S: Chemiluminescent visualization of generated by Candida albicans. Med Mycol. 2004 Oct;42(5):427-32. In the present study, we attempted to visualize the ROS, radical (O2-), generated by paraquat (PQ)-stimulated C. albicans using methyl-Cypridina-luciferin analog (MCLA) as a chemiluminescence probe. The light emission from the colonies was extinguished by superoxide dismutase (SOD), proving that the light emission was strictly due to the |
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| 16984741 | Saffi J, Sonego L, Varela QD, Salvador M: Antioxidant activity of in wild-type and superoxide dismutase deficient strains of Saccharomyces cerevisiae. Redox Rep. 2006;11(4):179-84. Our study investigated the antioxidant activity of in wild-type strain EG103 (SOD) Saccharomyces cerevisiae and isogenic mutant strains deficient in cytosolic superoxide dismutase (sod1delta), mitochondrial superoxide dismutase (sod2delta) or both (sod1delta sod2delta), metabolizing aerobically or anaerobically with and without the stressing agent paraquat. |
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| 17596439 | Peng J, Peng L, Stevenson FF, Doctrow SR, Andersen JK: and paraquat as synergistic environmental risk factors in sporadic Parkinson's disease accelerate age-related neurodegeneration. J Neurosci. 2007 Jun 27;27(26):6914-22. Furthermore, pretreatment with the synthetic superoxide dismutase/catalase mimetic, EUK-189, significantly attenuated neuronal death mediated by combined paraquat and iron treatment. |
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| 16195250 | Gong H, Singh SV, Singh SP, Mu Y, Lee JH, Saini SP, Toma D, Ren S, Kagan VE, Day BW, Zimniak P, Xie W: Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol. 2006 Feb;20(2):279-90. Epub 2005 Sep 29. The PXR-induced paraquat sensitivity was associated with decreased activities of superoxide dismutase and catalase, enzymes that scavenge and peroxide, respectively. |
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| 10923703 | Ye B, Gressel J: Transient, oxidant-induced antioxidant transcript and enzyme levels correlate with greater oxidant-resistance in paraquat-resistant Conyza bonariensis. Planta. 2000 Jun;211(1):50-61. By 6 h after sub-lethal paraquat treatment the activities of superoxide dismutase (EC 1.15.1.1), peroxidase (EC 1.11.1.11), reductase (EC 1.8.5), monodehydroascorbate reductase (EC 1.6.5.4), and peroxidase (EC 1.11.19) had increased, peaking at 24 h and then slowly reverting back to the basal level. |
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| 16413403 | Wilkinson SR, Prathalingam SR, Taylor MC, Ahmed A, Horn D, Kelly JM: Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei. Free Radic Biol Med. 2006 Jan 15;40(2):198-209. Epub 2005 Aug 18. The importance of one of the mitochondrial enzymes (TbSODA) only became apparent when parasites were exposed to the -generating agent paraquat following induction of RNAi. |
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| 11386371 | Santos R, Franza T, Laporte ML, Sauvage C, Touati D, Expert D: Essential role of superoxide dismutase on the pathogenicity of Erwinia chrysanthemi strain 3937. Mol Plant Microbe Interact. 2001 Jun;14(6):758-67. The deltasodA mutant was more sensitive to paraquat than the wild-type strain. |
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| 10464329 | Wenk J, Brenneisen P, Wlaschek M, Poswig A, Briviba K, Oberley TD, Scharffetter-Kochanek K: Stable overexpression of manganese superoxide dismutase in mitochondria identifies peroxide as a major oxidant in the AP-1-mediated induction of matrix-degrading metalloprotease-1. J Biol Chem. 1999 Sep 3;274(36):25869-76. The Mn-SOD-overexpressing cells revealed specific resistance to the (O-(2))-generating agent paraquat, whereas no resistance to UVA-generated oxidative stress was found. |
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| 12885779 | Rizhsky L, Liang H, Mittler R: The water-water cycle is essential for chloroplast protection in the absence of stress. J Biol Chem. 2003 Oct 3;278(40):38921-5. Epub 2003 Jul 28. Here we show that knockdown Arabidopsis plants with suppressed expression of the key water-water cycle enzyme, thylakoid-attached /zinc superoxide dismutase (KD-SOD), are suppressed in their growth and development. |
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| 15965076 | Chou CM, Huang CJ, Shih CM, Chen YP, Liu TP, Chen CT: Identification of three mutations in the Cu,Zn-superoxide dismutase (Cu,Zn-SOD) gene with familial amyotrophic lateral sclerosis: transduction of human Cu,Zn-SOD into PC12 cells by HIV-1 TAT protein basic domain. Ann N Y Acad Sci. 2005 May;1042:303-13. In undifferentiated PC12 cells, wild-type Tat-SOD1 could prevent DNA fragmentation due to attacks generated by 35 mM paraquat, whereas mutant Tat-D101G enhanced cell death. |
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| 12456885 | Kirby K, Hu J, Hilliker AJ, Phillips JP: RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress. J Biol Chem. 1999 May 7;274(19):13650-5. Because mitochondrial respiration is the principal source of reactive within cells, the mitochondrially localized superoxide dismutase (SOD) 2 is thought to play an important front-line defensive role against aging-related oxidative stress. |
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| 15479627 | Choi DG, Yoo NH, Yu CY, de Los Reyes B, Yun SJ: The activities of antioxidant enzymes in response to oxidative stresses and hormones in paraquat-tolerant Rehmannia glutinosa plants. J Biochem Mol Biol. 2004 Sep 30;37(5):618-24. The levels of peroxidase (APX), glutathione reductase (GR), non-specific peroxidase (POX), and superoxide dismutase (SOD) were 7.3-, 4.9-, 2.7- and 1.6-fold higher in PQ-tolerant R. glutinosa than in PQ-susceptible soybeans. |
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| 17013749 | Moeder W, Del Pozo O, Navarre DA, Martin GB, Klessig DF: Aconitase plays a role in regulating resistance to oxidative stress and cell death in Arabidopsis and Nicotiana benthamiana. Plant Mol Biol. 2007 Jan;63(2):273-87. Epub 2006 Oct 1. However, it bound the 5' UTR of the Arabidopsis chloroplastic CuZn superoxide dismutase 2 (CSD2) mRNA, and this binding was specific. Arabidopsis aconitase knockout (KO) plants were found to have significantly less chlorosis after treatment with the -generating compound, paraquat. |
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| 10416023 | Schultz JR, Clarke CF: Characterization of Saccharomyces cerevisiae -deficient mutants. Biofactors. 1999;9(2-4):121-9. Superoxide dismutase (SOD) activity decreased and catalase activity increased in both Q-deficient and atp2 delta mutants compared to wild-type cells, suggesting that such changes result from the loss of respiration rather than the lack of Q. |
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| 12701708 | Barna B, Fodor J, Pogany M, Kiraly Z: Role of reactive species and antioxidants in plant disease resistance. Pest Manag Sci. 2003 Apr;59(4):459-64. In addition, in in vitro tests, leaves from selected paraquat-tolerant tobacco plants were less sensitive to Alternaria alternata (Fr) Keissler infection than those of the control paraquat-sensitive tobacco leaves. Accordingly, superoxide dismutase (SOD) activity was higher in Xanthi tobacco leaves with SAR than without SAR. |
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| 16821718 | Krasowska A, Piasecki A, Polinceusz A, Prescha A, Sigler K: Amphiphilic amine-N-oxides with aliphatic alkyl chain act as efficient superoxide dismutase mimics, antioxidants and lipid peroxidation blockers in yeast. Folia Microbiol. 2006;51(2):99-107. They also enhance the survival of sod mutants of S. cerevisiae exposed to the hydrophilic -generating prooxidant paraquat and the amphiphilic hydroperoxide-producing tert-butylhydroperoxide (TBHP), and largely prevent TBHP-induced peroxidation of isolated yeast plasma membrane lipids. |
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| 18269170 | Spiegelman BM: Transcriptional control of energy homeostasis through the PGC1 coactivators. Novartis Found Symp. 2007;286:3-6; discusssion 6-12 This includes genes encoding mitochondrial proteins like SOD2, but also includes cytoplasmic proteins like catalase and GPX1. Cells lacking PGC1alpha are hypersensitive to death from oxidative stress caused by H2O2 or paraquat. |
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| 10224137 | Lin KI, Pasinelli P, Brown RH, Hardwick JM, Ratan RR: Decreased intracellular levels activate Sindbis virus-induced apoptosis. 162-3 This SV-induced decrease in O-2 levels appears to activate or modulate cell death, as a recombinant SV expressing the O-2 scavenging enzyme, /zinc superoxide dismutase (SOD), potentiates SV-induced apoptosis. Moreover, increasing intracellular O-2 by treatment of 3T3 cells with paraquat protects them from SV-induced death. |
1(0,0,0,1) | Details |
| 11550893 | Vontas JG, Tsakas SC, Loukas M, Hemingway J: Low-activity allele of -zinc superoxide dismutase (CuZnSOD) in Drosophila increases paraquat genotoxicity but does not affect near UV radiation damage. Genome. 2001 Aug;44(4):597-601. We incorporated a low-activity allele of -zinc superoxide dismutase (CuZnSOD), recovered from natural populations of Drosophila melanogaster, into standard marked strains and employed a somatic mutation and recombination test (SMART) to compare paraquat and near UV radiation genotoxicity in these strains. |
31(0,1,1,1) | Details |
| 19027846 | Peng J, Stevenson FF, Oo ML, Andersen JK: -enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activation. Free Radic Biol Med. 2009 Jan 15;46(2):312-20. Epub 2008 Nov 7. Furthermore, pretreatment with the synthetic superoxide dismutase/catalase mimetic, EUK-189, significantly decreased microglial activation mediated by combined paraquat and iron treatment. |
31(0,1,1,1) | Details |
| 17384197 | Passalacqua KD, Bergman NH, Lee JY, Sherman DH, Hanna PC: The global transcriptional responses of Bacillus anthracis Sterne (34F2) and a Delta sodA1 mutant to paraquat reveal metal ion homeostasis imbalances during endogenous stress. J Bacteriol. 2007 Jun;189(11):3996-4013. Epub 2007 Mar 23. A B. anthracis mutant lacking the superoxide dismutase gene sodA1 (Delta sodA1) had transcriptional responses to paraquat similar to, but notably larger than, those of the isogenic parental strain. |
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| 10092630 | Liochev SI, Benov L, Touati D, Fridovich I: Induction of the soxRS regulon of Escherichia coli by . J Biol Chem. 1999 Apr 2;274(14):9479-81. We demonstrate that raising [O-2] by mutational deletion of superoxide dismutases and/or by addition of paraquat, both under aerobic conditions, causes induction of a member of the soxRS regulon and that a mutational defect in soxRS eliminates that induction. |
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| 18997852 | Koleva DI, Petrova VY, Kujumdzieva AV: Comparison of enzymatic antioxidant defence systems in different metabolic types of yeasts. Can J Microbiol. 2008 Nov;54(11):957-63. The role of antioxidant enzymes in preventing oxidant-induced cytotoxicity (treatment with peroxide, paraquat, and was shown. Twofold higher superoxide dismutase (SOD) and catalase activities were detected in K. marxianus and R. glutinis when cells were cultured on |
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| 11045460 | Tamura M, Urano Y, Kikuchi K, Higuchi T, Hirobe M, Nagano T: Superoxide dismutase activity of iron (II) TPEN complex and its derivatives. . Chem Pharm Bull. 2000 Oct;48(10):1514-8. Fe (II) TPEN can act like native SOD in living cells, and protect Escherichia coli cells from free radical toxicity caused by paraquat. |
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| 10066423 | Balzan R, Agius DR, Bannister WH: Cloned prokaryotic iron superoxide dismutase protects yeast cells against oxidative stress depending on mitochondrial location. Biochem Biophys Res Commun. 1999 Mar 5;256(1):63-7. |
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| 11344148 | Valderas MW, Hart ME: Identification and characterization of a second superoxide dismutase gene (sodM) from Staphylococcus aureus. J Bacteriol. 2001 Jun;183(11):3399-407. |
2(0,0,0,2) | Details |
| 15763666 | Shin SY, Lee HS, Kwon SY, Kwon ST, Kwak SS: Molecular characterization of a cDNA encoding /zinc superoxide dismutase from cultured cells of Manihot esculenta. Am J Respir Cell Mol Biol. 2001 Apr;24(4):436-41. |
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| 11157941 | Merkamm M, Guyonvarch A: Cloning of the sodA gene from Corynebacterium melassecola and role of superoxide dismutase in cellular viability. J Bacteriol. 2001 Feb;183(4):1284-95. The growth rate of the SOD-deficient integrant was only slightly affected in BHI rich medium as well as in BMCG chemically defined medium, but was strongly affected by the presence of the redox-cycling agent paraquat. |
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| 11500564 | Karpinska B, Karlsson M, Schinkel H, Streller S, Suss KH, Melzer M, Wingsle G: A novel superoxide dismutase with a high isoelectric point in higher plants. expression, regulation, and protein localization. Plant Physiol. 2001 Aug;126(4):1668-77. Furthermore, the transcript levels of hipI-SOD and cytosolic SOD were found to respond differently to mechanical wounding, treatment with paraquat, and ozone. |
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| 15020251 | Bhattacharya J, GhoshDastidar K, Chatterjee A, Majee M, Majumder AL: Synechocystis Fe superoxide dismutase gene confers oxidative stress tolerance to Escherichia coli. Biochem Biophys Res Commun. 2004 Apr 2;316(2):540-4. The pET-FeSOD transformed E. coli showed significantly higher SOD activity and tolerance to paraquat-mediated growth inhibition compared to the empty vector transformed cells. |
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| 18073424 | Yang W, Li J, Hekimi S: A Measurable increase in oxidative damage due to reduction in detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans. Genetics. 2007 Dec;177(4):2063-74. Furthermore, although disruption of sod-1 or -2 expression produces numerous phenotypes, including increased sensitivity to paraquat and increased oxidative damage to proteins (except in daf-2 mutants), this fails to shorten the life span of these long-lived mutants. In fact, sod-1 (RNAi) increases the life span of daf-2 mutants and sod-2 (RNAi) that of clk-1 mutants. |
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| 14658382 | Yu T, Li YS, Chen XF, Hu J, Chang X, Zhu YG: Transgenic tobacco plants overexpressing cotton glutathione S-transferase (GST) show enhanced resistance to methyl viologen. J Plant Physiol. 2003 Nov;160(11):1305-11. Six antioxidant enzymes, glutathione S-transferase, peroxidase (EC 1.11.1.9), superoxide dismutase (EC 1.15.1.1), peroxidase (EC 1.11.1.7), catalase (EC 1.11.1.6), and peroxidase (EC 1.11.1.11) were monitored in transgenic lines and non-transgenic control during MV treatments. |
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| 17964427 | Kell A, Ventura N, Kahn N, Johnson TE: Activation of SKN-1 by novel kinases in Caenorhabditis elegans. Free Radic Biol Med. 2007 Dec 1;43(11):1560-6. Epub 2007 Sep 7. The SKN-1 transcription factor specifies cell fate of the EMS blastomere at the four-cell stage in the nematode Caenorhabditis elegans and also directs transcription of many genes responding to oxidative stress, including glutathione S-transferase, NAD (P) H:quinone oxidoreductase, and superoxide dismutase. SKN-1 localizes to the nucleus and directs transcription following exposure to paraquat, heat, hyperbaric and azide. |
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| 12368459 | Jakubovics NS, Smith AW, Jenkinson HF: Oxidative stress tolerance is (Mn (2+)) regulated in Streptococcus gordonii. Microbiology. 2002 Oct;148(Pt 10):3255-63. A single Mn (2+)-dependent superoxide dismutase (SOD), encoded by sodA, is expressed by S. gordonii and was > 10-fold up-regulated under oxidative stress conditions. Inactivation of sodA resulted in increased susceptibility of S. gordonii cells to growth inhibition by dioxygen (O (2)), and to killing by paraquat (a generator) and by peroxide (H (2) O (2)). |
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| 10480324 | Komada F, Nishiguchi K, Tanigawara Y, Iwakawa S, Okumura K: Effects of secretable SOD delivered by genetically modified cells on /xanthine oxidase and paraquat-induced cytotoxicity in vitro. Biol Pharm Bull. 1999 Aug;22(8):846-53. We designed a new eukaryotic expression vector for secretable superoxide dismutase (SOD), which expresses human SOD cDNA by fusing it to 1 connecting amino acid and the signal peptide DNA sequence of the human interleukin-2 (IL-2) gene (IL-SOD (2) cDNA). |
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| 11306437 | Ilizarov AM, Koo HC, Kazzaz JA, Mantell LL, Li Y, Bhapat R, Pollack S, Horowitz S, Davis JM: Overexpression of manganese superoxide dismutase protects lung epithelial cells against oxidant injury. 196-203. Cell lines overexpressing MnSOD, CAT, or MnSOD + CAT were assessed for tolerance to hyperoxia or paraquat. |
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| 19583935 | Cao XG, Hou LL, Chen JX, Lu Q: Effects of Bushen Kangshuai Tang in retrieving oxidative stress-induced reproductive defects in Caenorhabditis elegans. Zhong Xi Yi Jie He Xue Bao. 2009 Jun;7(6):532-40. RESULTS: Ultraviolet irradiation, heat-shock, and paraquat treatment could significantly reduce egg number in uterus and brood size, increase generation time, and suppress activities of catalase and superoxide dismutase of the treated wild-type N2 nematodes. |
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| 18725537 | Medicherla B, Goldberg AL: Heat shock and radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins. J Cell Biol. 2008 Aug 25;182(4):663-73. To understand how cells handle postsynthetically damaged proteins, we studied in Saccharomyces cerevisiae the effects on overall protein degradation of shifting from 30 to 38 degrees C, exposure to reactive species generators (paraquat or cadmium), or lack of superoxide dismutases. |
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| 10679488 | Drummond GR, Cai H, Davis ME, Ramasamy S, Harrison DG: Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by peroxide. Circ Res. 2000 Feb 18;86(3):347-54. However, cotreatment with paraquat and either Cu (2+)/Zn (2+) superoxide dismutase or the superoxide dismutase mimetic tetrakis (4- increased eNOS mRNA by 2.3- and 2.2-fold, respectively, implicating a role for H (2) O (2). |
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| 12021807 | Pinheiro R, Belo I, Mota M: Oxidative stress response of Kluyveromyces marxianus to peroxide, paraquat and pressure. Appl Microbiol Biotechnol. 2002 May;58(6):842-7. Epub 2002 Feb 8. The exposure for 1 h of K. marxianus at exponential growth phase with either H (2) O (2) or paraquat, under air pressure of 120 kPa or 600 kPa, induced an increase in both superoxide dismutase (SOD) and glutathione reductase (GR) content. |
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| 14677634 | Sampayo JN, Olsen A, Lithgow GJ: Oxidative stress in Caenorhabditis elegans: protective effects of superoxide dismutase/catalase mimetics. Aging Cell. 2003 Dec;2(6):319-26. Here we demonstrate that the mimetics, Euk-134 and Euk-8, confer resistance to the oxidative stress-inducing agent, paraquat and to thermal stress. |
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| 16466666 | Ishimoto N, Nemoto T, Nagayoshi K, Yamashita F, Hashida M: Improved anti-oxidant activity of superoxide dismutase by direct chemical modification. J Control Release. 2006 Mar 10;111(1-2):204-11. Epub 2006 Feb 7. To evaluate their effectiveness, an in vitro model of paraquat poisoning was developed with primary cultured rabbit alveolar type II cells. |
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| 16841217 | Tang L, Kwon SY, Kim SH, Kim JS, Choi JS, Cho KY, Sung CK, Kwak SS, Lee HS: Enhanced tolerance of transgenic potato plants expressing both superoxide dismutase and peroxidase in chloroplasts against oxidative stress and high temperature. Plant Cell Rep. 2006 Dec;25(12):1380-6. Epub 2006 Jul 14. |
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| 20131044 | Roehrs R, Freitas DR, Masuda A, Henriques JA, Guecheva TN, Ramos AL, Saffi J: Effect of treatment on superoxide dismutase-deficient yeast strains. J Exp Bot. 2002 Dec;53(379):2401-10. Possible adaptation effects induced by sub-lethal oxidative stress were monitored by pre-, co- and post-treatment with the oxidative agent paraquat. |
2(0,0,0,2) | Details |
| 11457951 | Youssefian S, Nakamura M, Orudgev E, Kondo N: Increased biosynthesis capacity of transgenic tobacco overexpressing an (thiol) lyase modifies plant responses to oxidative stress. Plant Physiol. 2001 Jul;126(3):1001-11. An examination of differences in the ROS scavenging system of the transgenic plants also demonstrated the specific accumulation of Cu/Zn superoxide dismutase transcripts, known to be induced by Cys or GSH, and elevated cellular superoxide dismutase activities. |
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| 11485197 | Leisinger U, Rufenacht K, Fischer B, Pesaro M, Spengler A, Zehnder AJ, Eggen RI: The peroxidase homologous gene from Chlamydomonas reinhardtii is transcriptionally up-regulated by singlet Plant Mol Biol. 2001 Jul;46(4):395-408. In contrast, the Gpxh mRNA levels were only weakly induced by exposure to the -generating compound paraquat and by peroxide. A comparison of the Gpxh mRNA levels with those of the heat shock protein HSP70A and the iron superoxide dismutase gene showed qualitative and quantitative differences for the three genes under oxidative stress conditions tested. |
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| 19043665 | Ding S, Lu Q, Zhang Y, Yang Z, Wen X, Zhang L, Lu C: Enhanced sensitivity to oxidative stress in transgenic tobacco plants with decreased glutathione reductase activity leads to a decrease in pool and redox state. Plant Mol Biol. 2009 Mar;69(5):577-92. Epub 2008 Nov 29. MV treatment induced an increase in the activities of GR, peroxidase, superoxide dismutase, and catalase. |
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| 11245791 | Mano J, Ohno C, Domae Y, Asada K: Chloroplastic peroxidase is the primary target of methylviologen-induced photooxidative stress in spinach leaves: its relevance to monodehydroascorbate radical detected with in vivo ESR. Biochim Biophys Acta. 2001 Apr 2;1504(2-3):275-87. Following APX, superoxide dismutase and (+)-glyceraldehyde 3-phosphate dehydrogenase, both of which are vulnerable to H2O2, were inactivated by MV plus light. |
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| 17440995 | Li YM, Chan HY, Huang Y, Chen ZY: Green tea catechins upregulate superoxide dismutase and catalase in fruit flies. Mol Nutr Food Res. 2007 May;51(5):546-54. Supplementation of 10 mg GTC/mL diet increased the survival time only in wild type Oregon-R-C (OR) but not in two mutant fly lines, SOD (n108)/TM3 (gene for superoxide dismutase (SOD) was knocked out) and Cat (n1)/TM3 (gene for catalase was knocked out), when the flies were challenged with paraquat or peroxide. |
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| 10569645 | Franco AA, Odom RS, Rando TA: Regulation of antioxidant enzyme gene expression in response to oxidative stress and during differentiation of mouse skeletal muscle. Free Radic Biol Med. 1999 Nov;27(9-10):1122-32. To investigate this important homeostatic response, we studied the effect of oxidative challenges on the expression of genes encoding the antioxidant enzymes Cu,Zn-superoxide dismutase (CuZnSOD), Mn-superoxide dismutase (MnSOD), peroxidase (GPx), and catalase (CAT) in myotube cultures. Using Northern blot analysis, we found that treatment with the pro-oxidant paraquat resulted in time- and dose-dependent increases of transcript levels that were greatest for GPx and CAT (approximately 4-5 fold). |
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| 19508366 | Wan X, Tan J, Lu S, Lin C, Hu Y, Guo Z: Increased tolerance to oxidative stress in transgenic tobacco expressing a wheat oxidase gene via induction of antioxidant enzymes is mediated by H2O2. Physiol Plant. 2009 May;136(1):30-44. Epub 2009 Feb 12. Higher activities and transcripts of antioxidant enzymes (superoxide dismutase, catalase, peroxidase and glutathione reductase) were observed in the transgenic plants compared to their wild-type controls under normal growth conditions. |
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| 12803620 | Jiang M, Zhang J: Cross-talk between and reactive species originated from oxidase in abscisic acid-induced antioxidant defence in leaves of maize seedlings. Plant Cell Environ. 2003 Jun;26(6):929-939. Treatment with ABA led to significant increases in the activity of plasma membrane oxidase, the production of leaf O2-, and the activities of several antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), peroxidase (APX) and glutathione reductase (GR). Treatment with oxidative stress induced by paraquat, which generates O2-, led to the induction of antioxidant defence enzymes, and the up-regulation was suppressed by the pretreatment of Ca2+ chelator and Ca2+ channel blockers. |
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| 12432032 | Jiang M, Zhang J: Water stress-induced abscisic acid accumulation triggers the increased generation of reactive species and up-regulates the activities of antioxidant enzymes in maize leaves. J Korean Med Sci. 2003 Oct;18(5):649-54. The interrelationship among water-stress-induced abscisic acid (ABA) accumulation, the generation of reactive species (ROS), and the activities of several antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), peroxidase (APX), and glutathione reductase (GR) was investigated in leaves of detached maize (Zea mays L.) plants exposed to -0.7 MPa water stress induced by polyethylene glycol (PEG 6000). A mild oxidative stress induced by paraquat, which generates O (2)(-) and then H (2) O (2), resulted in a significant enhancement in the activities of antioxidant enzymes in non-water-stressed leaves. |
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| 18039652 | Cocheme HM, Murphy MP: Complex I is the major site of mitochondrial production by paraquat. J Biol Chem. 2008 Jan 25;283(4):1786-98. Epub 2007 Nov 26. Here we show that in yeast and mammalian mitochondria, production by paraquat occurs in the mitochondrial matrix, as inferred from manganese superoxide dismutase-sensitive mitochondrial DNA damage, as well as from assays in isolated mitochondria, which were unaffected by exogenous superoxide dismutase. |
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| 16288465 | Liu J, Narasimhan P, Song YS, Nishi T, Yu F, Lee YS, Chan PH: Epo protects SOD2-deficient mouse astrocytes from damage by oxidative stress. Glia. 2006 Mar;53(4):360-5. Survivability of heterozygous SOD2 (-/+) mutant and wild-type mouse astrocyte cultures was the same under normal conditions but, after administration of 2 mM of paraquat, a reactive species generator, survivability of the SOD2 (-/+) astrocytes decreased remarkably compared with the wild-type cells. |
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| 19500570 | Grunewald A, Gegg ME, Taanman JW, King RH, Kock N, Klein C, Schapira AH: Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology. Exp Neurol. 2009 Sep;219(1):266-73. Epub 2009 Jun 3. There were increased basal levels of mitochondrial superoxide dismutase in these cells and an exaggerated increase of in response to paraquat-induced free radical formation. |
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| 11936578 | Candan F, Alagozlu H: Captopril inhibits the pulmonary toxicity of paraquat in rats. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16162-7. Epub 2002 Nov 27. Paraquat alone increased the level of lipid peroxidation (LPO) and the activity of superoxide dismutase (SOD) after 4, 12, 24 and 72 h of administration. |
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| 17628798 | Yu P: Enhancing survival of Escherichia coli by increasing the periplasmic expression of Cu,Zn superoxide dismutase from Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2007 Sep;76(4):867-71. Epub 2007 Jul 13. Significantly higher survival of strains was obtained in cells bearing the sod gene than in the control cells when the cells were treated by heat shock and -generating agents, such as paraquat and |
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| 15946826 | Borsetti F, Tremaroli V, Michelacci F, Borghese R, Winterstein C, Daldal F, Zannoni D: Tellurite effects on Rhodobacter capsulatus cell viability and superoxide dismutase activity under oxidative stress conditions. Res Microbiol. 2005 Aug;156(7):807-13. The latter effect was also seen upon incubation with sublethal amounts of paraquat, a cytosolic generator of anions (O2-), in parallel with a strong increase in tellurite resistance (TeR). |
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| 11700360 | Leclere V, Chotteau-Lelievre A, Gancel F, Imbert M, Blondeau R: Occurrence of two superoxide dismutases in Aeromonas hydrophila: molecular cloning and differential expression of the sodA and sodB genes. Microbiology. 2001 Nov;147(Pt 11):3105-11. Nevertheless, paraquat had no detectable effect on its production. |
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| 15641941 | Outten CE, Falk RL, Culotta VC: Cellular factors required for protection from hyperoxia toxicity in Saccharomyces cerevisiae. Biochem J. 2005 May 15;388(Pt 1):93-101. plays a significant role, since the majority of hyperoxia-sensitive mutants displayed cross-sensitivity to -generating agents, and mutants with compromised SOD (superoxide dismutase) activity were particularly vulnerable to hyperoxia. |
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| 11728823 | Jin LH, Bahn JH, Eum WS, Kwon HY, Jang SH, Han KH, Kang TC, Won MH, Kang JH, Cho SW, Park J, Choi SY: Transduction of human catalase mediated by an HIV-1 TAT protein basic domain and -rich peptides into mammalian cells. Free Radic Biol Med. 2001 Dec 1;31(11):1509-19. Antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) have been considered to have a beneficial effect against various diseases mediated by reactive oxygen species (ROS). In combination with transduced SOD, transduced catalase also resulted in a cooperative increase in cell viability when the cells were treated with paraquat, an intracellular antioxide anion generator. |
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| 20079141 | Ren JP, Zhao YW, Sun XJ: Toxic influence of chronic oral administration of paraquat on nigrostriatal dopaminergic neurons in C57BL/6 mice. Chin Med J. 2009 Oct 5;122(19):2366-71. At the same time, the activities of superoxide dismutase (SOD) and peroxidase (GSH-PX), and the content of malondialdehyde (MDA) in substantia nigra were measured by spectrophotometry. mRNA expression of dopamine transporter (DAT) in dopaminergic neurons of substantia nigra was also determined by reverse transcription (RT)-PCR technique. |
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| 11448761 | Orendi G, Zimmermann P, Baar C, Zentgraf U: Loss of stress-induced expression of catalase3 during leaf senescence in Arabidopsis thaliana is restricted to oxidative stress. Plant Sci. 2001 Jul;161(2):301-314. Different stress conditions can induce changes in the activity of the antioxidant enzymes superoxide dismutase (SOD, EC 1.15.1.1), peroxidase (APX, EC 1.11.1.11) and catalase (CAT, EC 1.11.1.6). The enzyme activities of all SOD and APX isoforms detected in young Arabidopsis leaves remained unaffected or slightly decreased after moderate paraquat treatment. |
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| 17923370 | Hong Y, Wang G, Maier RJ: The quinone reductase MdaB confers oxidative stress resistance to Helicobacter hepaticus. Microb Pathog. 2008 Feb;44(2):169-74. Epub 2007 Sep 6. The mdaB mutant was also more sensitive to oxidative stress reagents such as H (2) O (2), cumene hydroperoxide, t-butyl hydroperoxide, and paraquat. All H. hepaticus mdaB strains isolated constitutively up-expressed another oxidative stress-combating enzyme, superoxide dismutase; this is in contrast to H. pylori mdaB strains. |
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| 12578363 | Ruzsa SM, Scandalios JG: Altered Cu metabolism and differential transcription of Cu/ZnSod genes in a Cu/ZnSOD-deficient mutant of maize: evidence for a Cu-responsive transcription factor. Biochemistry. 2003 Feb 18;42(6):1508-16. Maize inbred line A351 exhibits extremely low levels of Cu/Zn superoxide dismutase (SOD) isozymes, three cytosolic and one chloroplastic, which are increased by supplying to near-toxic concentrations. |
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