Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
9626535 Karan V, Vitorovic S, Tutundzic V, Poleksic V: Functional enzymes activity and gill histology of carp after copper sulfate exposure and recovery. Ecotoxicol Environ Saf. 1998 May-Jun;40(1-2):49-55.

After a 14-day period of exposure to five concentrations of copper sulfate (0.25-4.0 mg/L CuSO4, values ranging from approximately 5 to 70% of the 96-h LC-50) and a recovery period of the same duration, activities of the functional enzymes alkaline phosphatase (AP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the blood serum and gills were determined.
6(0,0,1,1) Details
14452044 JOHNSON HL, MILLER RF: The interrelationships between dietary molybdenum, copper, sulfate, femur alkaline phosphatase activity and growth of the rat. J Nutr. 1961 Dec;75:459-64.
6(0,0,1,1) Details
3758940 Shaver WA, Bhatt H, Combes B: Low serum alkaline phosphatase activity in Wilson's disease. . Hepatology. 1986 Sep-Oct;6(5):859-63.

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16327168 Lai YL, Yamaguchi M: Effects of copper on bone component in the femoral tissues of rats: anabolic effect of zinc is weakened by copper. Biol Pharm Bull. 2005 Dec;28(12):2296-301.

Culture with zinc sulfate (10 (-4) M) caused a significant increase in calcium content and alkaline phosphatase activity in the diaphyseal and metaphyseal tissues.
Rats were orally administered copper sulfate (50, 100, or 200 microg Cu/100 g body weight) once daily for 7 d.
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11204710 Hatfield PG, Swenson CK, Kott RW, Ansotegui RP, Roth NJ, Robinson BL: Zinc and copper status in ewes supplemented with sulfate- and amino acid-complexed forms of zinc and copper. J Anim Sci. 2001 Jan;79(1):261-6.


Thirty 6-yr-old Targhee ewes were randomly allotted to one of five supplemental treatments to evaluate supplementation effects on liver and fecal Zn and Cu concentrations and serum alkaline phosphatase activity: 1) control, 2) Zn complex, 3) Zn and Cu (ZnCu) complex, 4) Zn sulfate, and 5) ZnCu sulfates.
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18831375 Mathur S, Gupta AK: Histoenzymological study on the toxicity of copper sulphate in the digestive glands of Lymnaea luteola. J Environ Biol. 2008 Mar;29(2):201-4.


However, alkaline phosphatase showed average activity in perialveolar region and perilobular margin during 24 and 48, and 72 hr of exposure respectively The changes in the activity of these enzymes were nonsignificant in alveolar margin and perialveolar region of the gland.
1(0,0,0,1) Details
12728080 Diaz-Gomez NM, Domenech E, Barroso F, Castells S, Cortabarria C, Jimenez A: The effect of zinc supplementation on linear growth, body composition, and growth factors in preterm infants. Pediatrics. 2003 May;111(5 Pt 1):1002-9.


We analyzed serum levels of total alkaline phosphatase, skeletal alkaline phosphatase (sALP), insulin growth factor (IGF)-I, IGF binding protein-3, IGF binding protein-1, zinc and copper, and the concentrations of zinc in erythrocytes.
1(0,0,0,1) Details
8310452 Ahmed HM, Shoka AA: Toxic interactions between copper sulphate and some organic agrochemicals. Toxicol Lett. 1994 Jan;70(1):109-19.


Copper sulphate synergised the elevation of serum alkaline phosphatase (AP) activity, and bilirubin concentration as well the reduction of hemoglobin concentration by zineb.
1(0,0,0,1) Details
12237810 Tripathi YB, Upadhyay AK: Effect of the alcohol extract of the seeds of Mucuna pruriens on free radicals and oxidative stress in albino rats. Phytother Res. 2002 Sep;16(6):534-8.


The activity of serum GOT, GPT and alkaline phosphatase was also unchanged.
1(0,0,0,1) Details
16847394 Kawada E, Moridaira K, Itoh K, Hoshino A, Tamura J, Morita T: In long-term bedridden elderly patients with dietary copper deficiency, biochemical markers of bone resorption are increased with copper supplementation during 12 weeks. Ann Nutr Metab. 2006;50(5):420-4. Epub 2006 Jul 17.

They had their diets supplemented with copper sulfate (3 mg/day) over 12 weeks in addition to their diet of only one kind of enteral food with a low concentration of copper.
Serum copper and ceruloplasmin, urinary deoxypyridinoline (DPD) and collagen-type 1 N-telopeptide (NTX) (biomarkers of bone resorption), serum osteocalcin (OC) and bone-specific alkaline phosphatase (Bone ALP) (biomarkers of bone formation) were analyzed at baseline, 4 and 12 weeks after copper supplementation.
1(0,0,0,1) Details
20045542 Bampidis VA, Christodoulou V, Chatzipanagiotou A, Sossidou E, Salangoudis A: Serum enzyme status of Chios ewes fed increasing amounts of copper from copper sulfate. Res Vet Sci. 2009 Dec 31.

This study aimed to evaluate effects of orally administered copper (Cu) to Chios sheep breed on serum levels of aspartate aminotransferase (AST), l-alanine aminotransferase (ALT), lactate deydrogenase (LDH) and alkaline phosphatase (ALP), in order to establish a practical and effective method in diagnosing the prehemolytic stage of chronic Cu poisoning.
1(0,0,0,1) Details
3660431 Kumar A, Sharma CB: Hematological indices in copper-poisoned rats. Toxicol Lett. 1987 Oct;38(3):275-8.


The effects of 30 days oral administration of a sublethal daily dose (0.1 g/kg body weight) of copper sulfate on the blood constituents of albino rats were studied.
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