| Name | CYP2E1 |
|---|---|
| Synonyms | CPE 1; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CPE1; CYP2E; CYP2E1; CYP2E1 protein… |
| Name | parathion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10794390 | Eaton DL: Biotransformation enzyme polymorphism and pesticide susceptibility. Neurotoxicology. 2000 Feb-Apr;21(1-2):101-11. For example, one or more PM have been identified in human CYP1A1, CYP1B1, CYP2C9, CYP2C18, CYP2D6, and CYP2E1. Recent studies using cDNA expressed human CYPs have suggested that CYP3A4 is the principal human CYP involved in the oxidation of parathion and probably other organo (thio) (OP) insecticides and thus PM in this CYP might influence susceptibility to OP. |
1(0,0,0,1) | Details |
| 16510128 | Patel S, Singh V, Kumar A, Gupta YK, Singh MP: Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration. Brain Res. 2006 Apr 7;1081(1):9-18. Epub 2006 Feb 28. The involvement of cytochrome P4502E1 and glutathione S-transferases A4-4 enzymes in the detoxification of several pesticides such as atrazine, fenamirol, organophosphorous insecticide parathion, methoxychlor, diethyl dithiocarbamate and paraquat has been known. The contribution of CYP2E1 and GSTA4-4 in neuronal toxicity has also been reported. |
5(0,0,0,5) | Details |
| 9023313 | Butler AM, Murray M: Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation. J Pharmacol Exp Ther. 1997 Feb;280(2):966-73. |
0(0,0,0,0) | Details |
| 10414794 | Mutch E, Blain PG, Williams FM: The role of metabolism in determining susceptibility to parathion toxicity in man. Toxicol Lett. 1999 Jun 30;107(1-3):177-87. |
0(0,0,0,0) | Details |
| 8615874 | O'Shaughnessy JA, Sultatos LG: Interaction of and the organophosphorus insecticide parathion. . Biochem Pharmacol. 1995 Nov 27;50(11):1925-32. |
0(0,0,0,0) | Details |