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Laplaud PM, Dantoine T, Chapman MJ: Paraoxonase as a risk marker for cardiovascular disease: facts and hypotheses. Clin Chem Lab Med. 1998 Jun;36(7):431-41.
PON1 was originally found to be responsible for the hydrolysis of paraoxon, a catabolite of the insecticide parathion, but this enzyme is equally able to hydrolyze other substrates such as phenyl acetate.
Results from these investigations are conflicting, and recent data suggest a complex pattern with influences from other polymorphisms in either the PON1 and/or the PON2 and PON3 genes, or even another region of the gene cluster. |
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