| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | parathion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11032765 | Carlson K, Jortner BS, Ehrich M: Organophosphorus compound-induced apoptosis in SH-SY5Y human neuroblastoma cells. Toxicol Appl Pharmacol. 2000 Oct 15;168(2):102-13. OP compounds induced significant time-dependent increases in caspase-3 activation following paraoxon (1 mM), parathion (100 microM, 1 mM), PSP (10 microM, 100 microM, 1 mM), TOTP (100 microM, 1 mM), and TPPi (1 mM) exposure (p < 0.05). |
245(3,3,3,5) | Details |
| 12831782 | Saleh AM, Vijayasarathy C, Masoud L, Kumar L, Shahin A, Kambal A: Paraoxon induces apoptosis in EL4 cells via activation of mitochondrial pathways. Toxicol Appl Pharmacol. 2003 Jul 1;190(1):47-57. Recently, we have shown that, at noncholinergic doses (1 to 10 nM), POX (the bioactive metabolite of parathion) causes apoptotic cell death in murine EL4 T-lymphocytic leukemia cell line through activation of caspase-3. |
81(1,1,1,1) | Details |
| 12518333 | Saleh AM, Vijayasarathy C, Fernandez-Cabezudo M, Taleb M, Petroianu G: Influence of paraoxon (POX) and parathion (PAT) on apoptosis: a possible mechanism for toxicity in low-dose exposure. J Appl Toxicol. 2003 Jan-Feb;23(1):23-9. We examined cellular responses, including induction of apoptosis, involvement of a caspase cascade, the activity of effector caspase (caspase-3) and the biochemical and morphological changes that are the hallmarks of classical apoptosis. |
1(0,0,0,1) | Details |
| 17561261 | Tian F, Wu X, Pan H, Jiang H, Kuo YL, Marini AM: Inhibition of protein kinase C protects against paraoxon-mediated neuronal cell death. Neurotoxicology. 2007 Jul;28(4):843-9. Epub 2007 Apr 20. Paraoxon, the active metabolite of parathion, is an acetylcholinesterases (AChE) inhibitor that kills cultured cerebellar granule cell neurons via an apoptotic mechanism. We also show that the pretreatment of Ro-31-8220 blocks paraoxon-induced caspase-3 activity completely. |
1(0,0,0,1) | Details |