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Laplaud PM, Dantoine T, Chapman MJ: Paraoxonase as a risk marker for cardiovascular disease: facts and hypotheses. Clin Chem Lab Med. 1998 Jun;36(7):431-41.
A number of related factors, which include the heterogeneity of the high density lipoprotein particles incorporating PON (s), the metabolism of associated apolipoproteins such as apoJ/clusterin, the respective roles of PON (s) and other high density lipoprotein-associated enzymes such as platelet-activating-factor acetyl-hydrolase and lecithin-cholesterol acyltransferase, modifications of high density lipoprotein composition and activity under acute-phase conditions, the dietary and environmental regulation of PON (s), and the actual in situ availability of PON in the atherosclerotic artery wall, must equally be taken into account.
PON1 was originally found to be responsible for the hydrolysis of paraoxon, a catabolite of the insecticide parathion, but this enzyme is equally able to hydrolyze other substrates such as phenyl acetate. |
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