Protein Information

Name phosphodiesterase
Synonyms CAMP specific phosphodiesterase variant PDE4A 10; CAMP specific phosphodiesterase variant TM3; CAMP specific phosphodiesterase; Cyclic AMP phosphodiesterase PDE4A11; Cyclic AMP specific phosphodiesterase HSPDE4A10; DPDE 2; DPDE2; PDE 4…

Compound Information

Name parathion
CAS

Reference List

PubMed Abstract RScore(About this table)
17021221 de la Pena Mattozzi M, Tehara SK, Hong T, Keasling JD: Mineralization of paraoxon and its use as a sole C and P source by a rationally designed catabolic pathway in Pseudomonas putida. Appl Environ Microbiol. 2006 Oct;72(10):6699-706.


This strain was engineered with the pnp operon from Pseudomonas sp. strain ENV2030, which encodes enzymes that transform p-nitrophenol into beta-ketoadipate, and with a synthetic operon encoding an organophosphate hydrolase (encoded by opd) from Flavobacterium sp. strain ATCC 27551, a phosphodiesterase (encoded by pde) from Delftia acidovorans, and an alkaline phosphatase (encoded by phoA) from Pseudomonas aeruginosa HN854 under control of a constitutive promoter.
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1761796 Pala I, Vig PJ, Desaiah D, Srinivasan A: In vitro effects of organophosphorus compounds on calmodulin activity. J Appl Toxicol. 1991 Dec;11(6):391-5.

In vitro effects of organophosphorus compounds (OP), such as malathion (M), methyl parathion (MP) and ethyl parathion (EP), on calmodulin (CaM) activity and its active conformation were studied to understand the mechanism (s) of neurotoxicity, since CaM is known to regulate Ca2+ transport and the enzymes involved in signal transduction and nucleotide metabolism.
The biological activity of CaM was assessed as a measure of phosphodiesterase (PDE) stimulation.
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