Protein Information

Name succinate dehydrogenase (protein family or complex)
Synonyms Succinate dehydrogenase; Succinate dehydrogenases

Compound Information

Name parathion
CAS

Reference List

PubMed Abstract RScore(About this table)
2153406 Moreno AJ, Madeira VM: Interference of parathion with mitochondrial bioenergetics. Biochim Biophys Acta. 1990 Feb 2;1015(2):361-7.

The inhibitory action of parathion on phosphorylation efficiency could be related with the following findings: (1) a direct effect on the succinate dehydrogenase-ubiquinone segment of the redox chain; (2) a direct action on the ATP synthetase complex; (3) partial inhibition of the phosphate transporter.
81(1,1,1,1) Details
4006833 Prasada Roa KS, Ahammad Sahib IK, Ramana Rao KV: Methyl parathion (O-O-dimethyl O-4-nitrophenyl thiophosphate) effects on whole-body and tissue respiration in the teleost, Tilapia mossambica (Peters). Ecotoxicol Environ Saf. 1985 Jun;9(3):339-45.

The activities of the respiratory enzymes succinate dehydrogenase, malate dehydrogenase, and cytochrome-c oxidase also decreased considerably under methyl parathion exposure in muscle, gill, liver, and brain tissues.
6(0,0,1,1) Details
1877982 Reddy MS, Rao KV: Phosphamidon, methylparathion and dichlorvos impact on tissue oxidative metabolism in penaeid prawn, Metapenaeus monoceros. Biochem Int. 1991 Feb;23(3):439-47.


The OPI are found to inhibit the activity levels of acetylcholinesterase, succinate dehydrogenase, isocitrate dehydrogenase, pyruvate dehydrogenase, lactate dehydrogenase and cytochrome-c-oxidase and cause accumulation of acetylcholine in the hepatopancreas and muscle tissues.
1(0,0,0,1) Details