| Name | glutathione S transferases |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | parathion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3768034 | Radulovic LL, LaFerla JJ, Kulkarni AP: Human placental glutathione S-transferase-mediated metabolism of methyl parathion. Biochem Pharmacol. 1986 Oct 15;35(20):3473-80. |
162(2,2,2,2) | Details |
| 3825174 | Radulovic LL, Kulkarni AP, Dauterman WC: Biotransformation of methyl parathion by human foetal liver glutathione S-transferases: an in vitro study. Xenobiotica. 1987 Jan;17(1):105-14. The ability of human foetal liver glutathione S-transferases to catalyse the metabolism of methyl parathion exclusively to desmethyl parathion via O-dealkylation represents a major qualitative biochemical difference from the rat-liver isozymes. |
94(1,1,3,4) | Details |
| 2042734 | Tracy JW, O'Leary KA: Analysis of glutathione S-transferase-catalyzed S-alkylglutathione formation by high-performance liquid chromatography. Anal Biochem. 1991 Feb 15;193(1):1-5. The utility of the method is illustrated by the use of partially purified preparations of rat liver glutathione S-transferases and several prototypic substrates including iodomethane, iodoethane, dichlorvos, and methyl parathion. |
83(1,1,1,3) | Details |
| 11407025 | Kostaropoulos I, Papadopoulos AI, Metaxakis A, Boukouvala E, Papadopoulou-Mourkidou E: The role of glutathione S-transferases in the detoxification of some organophosphorus insecticides in larvae and pupae of the yellow mealworm, Tenebrio molitor (Coleoptera: Tenebrionidae). Pest Manag Sci. 2001 Jun;57(6):501-8. The correlation between the natural levels of glutathione S-transferase (GST) and the tolerance to the organophosphorus insecticides parathion-methyl and paraoxon-methyl, as well as the interaction of affinity-purified enzyme and the insecticides were investigated in order to collect further information on the role of the glutathione S-transferase system as a mechanism of defence against insecticides in insects. |
82(1,1,1,2) | Details |
| 8703089 | Syvanen M, Zhou Z, Wharton J, Goldsbury C, Clark A: Heterogeneity of the glutathione transferase genes encoding enzymes responsible for insecticide degradation in the housefly. J Mol Evol. 1996 Sep;43(3):236-40. One of the four glutathione-S-transferases (GST) that is overproduced in the insecticide-resistant Cornell-R strain of the housefly (Musca domestica) produces an activity that degrades the insecticide dimethyl parathion and conjugates to lindane. |
31(0,1,1,1) | Details |
| 11166672 | Anguiano OL, Caballero de Castro A, Pechen de D'Angelo AM: The role of conjugation in the regulation of early toad embryos' tolerance to pesticides. Comp Biochem Physiol C Toxicol Pharmacol. 2001 Jan;128(1):35-43. Reduced (GSH) content and glutathione S-transferase (GSH S-transferase) activity were investigated in developing toad embryos exposed to parathion, malathion, lindane and dieldrin. |
31(0,1,1,1) | Details |
| 15103050 | Abel EL, Bammler TK, Eaton DL: Biotransformation of methyl parathion by glutathione S-transferases. . Toxicol Sci. 2004 Jun;79(2):224-32. Epub 2004 Apr 21. |
7(0,0,1,2) | Details |
| 16510128 | Patel S, Singh V, Kumar A, Gupta YK, Singh MP: Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration. Brain Res. 2006 Apr 7;1081(1):9-18. Epub 2006 Feb 28. The involvement of cytochrome P4502E1 and glutathione S-transferases A4-4 enzymes in the detoxification of several pesticides such as atrazine, fenamirol, organophosphorous insecticide parathion, methoxychlor, diethyl dithiocarbamate and paraquat has been known. |
7(0,0,1,2) | Details |
| 18571824 | Celik I, Suzek H: Subacute effects of methyl parathion on antioxidant defense systems and lipid peroxidation in rats. Food Chem Toxicol. 2008 Aug;46(8):2796-801. Epub 2008 May 17. In this study we aimed to examine how methyl parathion (MP) at sublethal dosages affects on malondialdehyde (MDA) content and antioxidant defense system (ADS) such as (GSH), glutathione reductase (GR), superoxide dismutase (SOD) and glutathione-S-transferase (GST) in various tissues of rats exposed to 19 and 38 millimole (mM) MP dosages as drinking water ad libitum for 28 days continuously. |
6(0,0,1,1) | Details |
| 16675014 | Bianchini A, Monserrat JM: Effects of methyl parathion on Chasmagnathus granulatus hepatopancreas: protective role of sesamol. Ecotoxicol Environ Saf. 2007 May;67(1):100-8. Epub 2006 May 3. Antioxidant enzyme activities (catalase and glutathione S-transferase) and lipid peroxidation (LPO) levels were also increased in hepatopancreas of crabs injected with methyl parathion. |
6(0,0,1,1) | Details |
| 11583927 | Wei SH, Clark AG, Syvanen M: Identification and cloning of a key insecticide-metabolizing glutathione S-transferase (MdGST-6A) from a hyper insecticide-resistant strain of the housefly Musca domestica. Insect Biochem Mol Biol. 2001 Nov 1;31(12):1145-53. When expressed in Escherichia coli, one of the cloned GSTs, MdGST-6A, produces an enzyme that conjugates to the insecticides methyl parathion and lindane. |
2(0,0,0,2) | Details |
| 17184855 | Trute M, Gallis B, Doneanu C, Shaffer S, Goodlett D, Gallagher E: Characterization of hepatic glutathione S-transferases in coho salmon (Oncorhynchus kisutch). Aquat Toxicol. 2007 Feb 28;81(2):126-36. Epub 2006 Nov 24. However, there was no observable cytosolic GST activity towards the pesticides methyl parathion or atrazine, or products of oxidative stress, such as cumene hydroperoxide and |
2(0,0,0,2) | Details |
| 9755475 | Huang HS, Hu NT, Yao YE, Wu CY, Chiang SW, Sun CN: Molecular cloning and heterologous expression of a glutathione S-transferase involved in insecticide resistance from the diamondback moth, Plutella xylostella. Insect Biochem Mol Biol. 1998 Sep;28(9):651-8. Reverse-transcription polymerase chain reaction (RT-PCR) using midgut mRNA from a methyl parathion resistant MPA strain and degenerate primers complimentary to the N-terminal and internal amino acid sequences of GST-3 generated a 128 bp DNA product. |
2(0,0,0,2) | Details |
| 3530629 | Wood E, Casabe N, Melgar F, Zerba E: Distribution and properties of glutathione S-transferase from T. infestans. Comp Biochem Physiol B. 1986;84(4):607-17. The glutathione transferase from T. infestans is able to render aqueous metabolites when incubated in vitro with malathion, parathion and fenitrothion. |
2(0,0,0,2) | Details |
| 18655848 | Monteiro DA, Rantin FT, Kalinin AL: The effects of on oxidative stress biomarkers in the freshwater characid fish matrinxa, Brycon cephalus (Gunther, 1869) exposed to organophosphate insecticide Folisuper 600 BR (methyl parathion). Comp Biochem Physiol C Toxicol Pharmacol. 2009 Jan;149(1):40-9. Epub 2008 Jul 4. Catalase (CAT), peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg (-1) for 8 weeks. |
1(0,0,0,1) | Details |
| 10794390 | Eaton DL: Biotransformation enzyme polymorphism and pesticide susceptibility. Neurotoxicology. 2000 Feb-Apr;21(1-2):101-11. Numerous specific genetic polymorphisms (PM) in the multi-gene families of cytochromes P450 (CYPs) and glutathione S-transferases (GSTs) have been described in the human population in the past decade. Recent studies using cDNA expressed human CYPs have suggested that CYP3A4 is the principal human CYP involved in the oxidation of parathion and probably other organo (thio) (OP) insecticides and thus PM in this CYP might influence susceptibility to OP. |
1(0,0,0,1) | Details |
| 3178883 | Nemery B, Aldridge WN: Studies on the metabolism of the pneumotoxin O,S,S-trimethyl phosphorodithioate--II. Biochem Pharmacol. 1988 Oct 1;37(19):3717-22. Other studies had shown binding of radioactivity and OSMeO- production to be cytochrome P-450-dependent processes in microsomes and SSMeO- production to result from the action of cytosolic glutathione-S-transferase on OSSMe. |
1(0,0,0,1) | Details |
| 16546452 | Monteiro DA, de Almeida JA, Rantin FT, Kalinin AL: Oxidative stress biomarkers in the freshwater characid fish, Brycon cephalus, exposed to organophosphorus insecticide Folisuper 600 (methyl parathion). Comp Biochem Physiol C Toxicol Pharmacol. 2006 Jun;143(2):141-9. Epub 2006 Mar 20. The effect of a single exposure to 2 mg L (- 1) of a commercial formulation of MP (MPc: Folisuper 600 (R), MP 600 g L (- 1)) on catalase (CAT), peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), (GSH) and lipid peroxidation (LPO) of the liver, white muscle and gills of Brycon cephalus was evaluated after 96 h of treatment. |
1(0,0,0,1) | Details |
| 16293285 | Amaya-Chavez A, Martinez-Tabche L, Lopez-Lopez E, Galar-Martinez M: Methyl parathion toxicity to and removal efficiency by Typha latifolia in water and artificial sediments. Chemosphere. 2006 May;63(7):1124-9. Epub 2005 Nov 15. Pesticide concentration, chlorophyll content and glutathione S-transferase (GST) activity were quantified. |
1(0,0,0,1) | Details |
| 18533248 | Almeida DV, Trindade GS, Geracitano LA, Barros DM, Monserrat JM, Marins LF: Initial results in the development of a reporter cell line for toxicology studies at gene expression level: activation of the electrophile-responsive element by and methyl parathion. Mar Environ Res. 2008 Jul;66(1):158-60. Epub 2008 Mar 8. In order to evaluate the molecular response triggered by these pollutants, a stable cell line was produced, which carries a transgene comprised of the green fluorescent protein (GFP) reporter gene under transcriptional control of the mouse glutathione-S-transferase (gst1) electrophile-responsive element fused to the mouse metallothionein (mt1) minimal promoter. |
1(0,0,0,1) | Details |
| 12088537 | Fragoso DB, Guedes RN, Guedes RN, Picanco MC, Zambolim L: Insecticide use and organophosphate resistance in the coffee leaf miner Leucoptera coffeella (Lepidoptera: Lyonetiidae). Bull Entomol Res. 2002 Jun;92(3):203-12. Increasing rates of insecticide use against the coffee leaf minerLeucoptera coffeella (Guerin-Meneville) and field reports on insecticide resistance led to an investigation of the possible occurrence of resistance of this species to some of the oldest insecticides used against it in Brazil: chlorpyrifos, disulfoton, ethion and methyl parathion. Results from insecticide bioassays with synergists (diethyl piperonyl butoxide and triphenyl suggested that cytochrome P450-dependent monooxygenases may play a major role in resistance with minor involvement of esterases and glutathione S-transferases. |
1(0,0,0,1) | Details |
| 19253540 | Na H, Huang Q, Chen Y, Huang H: [Differential proteins revealed with proteomics in the brain tissue of Paralichthys olivaceus under the stress of methyl parathion]. Se Pu. 2008 Nov;26(6):662-6. The results showed that heat shock protein 70, glutathione S-transferase and cytochrome P450 were significantly found in those differential proteins. |
1(0,0,0,1) | Details |
| 2559113 | Jaramillo-Juarez F, Posadas del Rio FA, Reyes JL, Rodriguez ML, Sanchez EI, Cuellar LH: Effects of intrauterine exposure to parathion on the activity of renal ATPases in offspring. J Appl Toxicol. 1989 Dec;9(6):401-5. The enzymes tested were the (Na+-K+)- and the Mg2+-dependent ATPases, the glutathione S-transferases and carboxylesterases. |
1(0,0,0,1) | Details |
| 7722883 | Lodovici M, Aiolli S, Monserrat C, Dolara P, Medica A, Di Simplicio P: Effect of a mixture of 15 commonly used pesticides on DNA levels of and xenobiotic metabolizing enzymes in rat liver. J Environ Pathol Toxicol Oncol. 1994;13(3):163-8. The level of 8-OH- in rat liver DNA was measured as an index of oxidative damage after treating rats for 10 days at a dose ranging from 0.75 to 10 mg/kg with a mixture of 15 pesticides (dithiocarbamate, benomyl, thiabendazole, diphenylamine, chlorthalonil, procimidone, methidathion, chlorpyrifos-ethyl, fenarimol, parathion-methyl, chlorpropham, parathion, vinclozolin, chlorfenvinphos, pirimiphos-ethyl) commonly found in foods of central Italy. The administration of the pesticide mixture dose dependently reduced benzo (a) pyrene hydroxylase, N-demethylase activities, peroxidase, glutathione reductase, glutathione-S-transferase and thiol transferase activities in the liver. |
1(0,0,0,1) | Details |
| 8516780 | Huang YS, Sultatos LG: -dependent biotransformation of methyl parathion by mouse liver in vitro. Toxicol Lett. 1993 Jun;68(3):275-84. |
0(0,0,0,0) | Details |
| 17089332 | Yu SJ, McCord E Jr: Lack of cross-resistance to indoxacarb in insecticide-resistant Spodoptera frugiperda (Lepidoptera: Noctuidae) and Plutella xylostella (Lepidoptera: Yponomeutidae). Pest Manag Sci. 2007 Jan;63(1):63-7. Two field strains of the fall armyworm, Spodoptera frugiperda (JE Smith), collected from corn in north Florida showed high resistance to carbaryl (626- and 1159-fold) and moderate resistance to parathion-methyl (30- and 39-fold) as compared with a laboratory susceptible strain. |
0(0,0,0,0) | Details |
| 4064931 | Graziano MJ, Gairola C, Dorough HW: Effects of cigarette smoke and dietary levels on selected lung and hepatic biotransformation enzymes in mice. Drug Nutr Interact. 1985;3(4):213-22. Smoking had no effect on hepatic aryl hydrocarbon hydroxylase (AHH), UDP-glucuronyltransferase, glutathione S-transferase, parathion desulfurase, or parathion esterase activity. |
0(0,0,0,0) | Details |
| 11886776 | Tsagkarakou A, Pasteur N, Cuany A, Chevillon C, Navajas M: Mechanisms of resistance to organophosphates in Tetranychus urticae (Acari: Tetranychidae) from Greece. Insect Biochem Mol Biol. 2002 Apr;32(4):417-24. We investigated the mechanisms conferring resistance to methyl-parathion (44-fold) and to methomyl (8-fold) in Tetranychus urticae from Greece by studying the effect of synergists on the resistance and the kinetic characteristics of various enzymes in a resistant strain (RLAB) and a susceptible reference strain (SAMB). |
0(0,0,0,0) | Details |