| Name | CYP1A1 |
|---|---|
| Synonyms | AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1… |
| Name | parathion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10794390 | Eaton DL: Biotransformation enzyme polymorphism and pesticide susceptibility. Neurotoxicology. 2000 Feb-Apr;21(1-2):101-11. For example, one or more PM have been identified in human CYP1A1, CYP1B1, CYP2C9, CYP2C18, CYP2D6, and CYP2E1. Recent studies using cDNA expressed human CYPs have suggested that CYP3A4 is the principal human CYP involved in the oxidation of parathion and probably other organo (thio) (OP) insecticides and thus PM in this CYP might influence susceptibility to OP. |
1(0,0,0,1) | Details |
| 9473531 | Miranda CL, Henderson MC, Buhler DR: Evaluation of chemicals as inhibitors of trout cytochrome P450s. Toxicol Appl Pharmacol. 1998 Feb;148(2):237-44. Three monooxygenase activities, namely, (omega-1)-hydroxylase (LA-OH), 7,12-dimethylbenz [a] anthracene hydroxylase (DMBA-OH), and 6beta-hydroxylase (PROG-OH) activities were used as functional markers for trout hepatic CYP2K1, CYP1A1, and CYP3A27, respectively. These compounds, as well as ellipticine, parathion, and alpha-naphthoflavone, were the strongest inhibitors of DMBA-OH and PROG-OH activities. |
1(0,0,0,1) | Details |
| 11684353 | Albores A, Ortega-Mantilla G, Sierra-Santoyo A, Cebrian ME, Munoz-Sanchez JL, Calderon-Salinas JV, Manno M: Cytochrome P450 2B (CYP2B)-mediated activation of methyl-parathion in rat brain extracts. Toxicol Lett. 2001 Oct 15;124(1-3):1-10. |
0(0,0,0,0) | Details |
| 10414794 | Mutch E, Blain PG, Williams FM: The role of metabolism in determining susceptibility to parathion toxicity in man. Toxicol Lett. 1999 Jun 30;107(1-3):177-87. |
0(0,0,0,0) | Details |