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Segura P, Chavez J, Montano LM, Vargas MH, Delaunois A, Carbajal V, Gustin P: Identification of mechanisms involved in the acute airway toxicity induced by parathion. Naunyn Schmiedebergs Arch Pharmacol. 1999 Dec;360(6):699-710.
The isolated perfused rabbit lung preparation was used to study the acute effects of Pth on airway responsiveness to ACh (10 (-8)-10 (-3) M), histamine (10 (-8)-10 (-3) M) and substance P (10 (-10)-10 (-6) M), pulmonary acetylcholinesterase inhibition and cytochrome P450 (P450) activity, and their modifications with previous administration of Pth (1 mg/kg s.c. daily, 7 days). |
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