Protein Information

Name lactate dehydrogenase (protein family or complex)
Synonyms LDH; lactate dehydrogenase; lactate dehydrogenases

Compound Information

Name parathion
CAS

Reference List

PubMed Abstract RScore(About this table)
15147928 de Aguiar LH, Moraes G, Avilez IM, Altran AE, Correa CF: Metabolical effects of Folidol 600 on the neotropical freshwater fish matrinxa, Brycon cephalus. Environ Res. 2004 Jun;95(2):224-30.

The neotropical freshwater fish matrinxa, Brycon cephalus (Gunther, 1869), was exposed to 1/3 of 96 h-LC50 of Folidol 600 (methyl parathion) for 96 h and allowed to recover for 24, 48, 96, and 192 h.
Acetylcholinesterase (AChE), alanine aminotransferase (ALAT), aspartate aminotransferase (AAT), lactate dehydrogenase (LDH), malate dehydrogenase (MDH), and glutamate dehydrogenase (GDH) were assayed in brain, liver, muscle, and plasma.
1(0,0,0,1) Details
2099789 Tripathi G, Shukla SP: Enzymatic and ultrastructural studies in a freshwater catfish: impact of methyl parathion. Biomed Environ Sci. 1990 Jun;3(2):166-82.

Exposure to a sublethal concentration of methyl parathion (MEP) reduced the activity of cytoplasmic malate dehydrogenase, mitochondrial malate dehydrogenase, and lactate dehydrogenase by 30 to 49% in the liver and the skeletal muscle of the freshwater catfish.
81(1,1,1,1) Details
17964717 Celik I, Suzek H: The hematological effects of methyl parathion in rats. J Hazard Mater. 2008 May 30;153(3):1117-21. Epub 2007 Sep 25.

The effects of methyl parathion (MP) at sublethal concentration on hematological constituent [red blood corpuscles (RBC), white blood corpuscles (WBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet (PLT) counts, hemoglobin (Hb) and hematocrite (HCT) levels] and serum damage marker enzymes [aspartate aminotransferase (AST), alanin aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH)] of rats were investigated under laboratory conditions. 5 and 10 ppm dosages of MP were administered orally to six female rats ad libitum during the tests for 4 weeks consecutively.
6(0,0,1,1) Details
16783732 Narayana K, Prashanthi N, Nayanatara A, Kumar HH, Abhilash K, Bairy KL: Neonatal methyl parathion exposure affects the growth and functions of the male reproductive system in the adult rat. Folia Morphol. 2006 Feb;65(1):26-33.

Methyl parathion lowered the body weights from days 10 to 24 (p < 0.01), the weights of the reproductive organs (p < 0.05-0.01), the epididymal sperm count (p < 0.01) and the homogenisation-resistant testicular spermatid head count (p < 0.01) and also decreased acid phosphatase (ACP), cholesterol, uric acid, protein, ascorbic acid, and lactate dehydrogenase (p < 0.01) levels in the testis but only ACP and cholesterol in the epididymis.
6(0,0,1,1) Details
7946013 Zhu S, Liu YG: Toxicity and toxicokinetics of MeISP in isolated rat hepatocytes. . Biomed Environ Sci. 1994 Jun;7(2):169-79.


It was found that at the final concentration of 1.5 mmol/L, MeISP can (1) result in an increase of leakage of intracellular enzymes, alanine amino-transferase (ALT), lactate dehydrogenase (LDH), beta-glucuronidase (beta-GDase) and acid phosphatase (AcP) to the medium in a dose-dependent fashion; (2) give rise to obvious plasma membrane blebbing; (3) rapidly deplete the intracellular GSH and (4) almost completely inhibit the protein synthesis and gluconeogenesis from sodium pyruvate.
1(0,0,0,1) Details
1830481 Reddy MS, Rao KV: Tissue glycolytic potentials of penaeid prawn, Metapenaeus monoceros during methylparathion, carbaryl and aldrin exposure. Biochem Int. 1991 Jan;23(2):367-75.


The decrease in the lactate dehydrogenase activity levels and an increase in the lactate content indicative of reduced mobilization of pyruvate into the citric acid cycle.
1(0,0,0,1) Details
1877982 Reddy MS, Rao KV: Phosphamidon, methylparathion and dichlorvos impact on tissue oxidative metabolism in penaeid prawn, Metapenaeus monoceros. Biochem Int. 1991 Feb;23(3):439-47.


The OPI are found to inhibit the activity levels of acetylcholinesterase, succinate dehydrogenase, isocitrate dehydrogenase, pyruvate dehydrogenase, lactate dehydrogenase and cytochrome-c-oxidase and cause accumulation of acetylcholine in the hepatopancreas and muscle tissues.
1(0,0,0,1) Details
20021006 Yildiz D, Dalkilic S, Yildiz H, Oztas H: Methyl Parathion-Induced Changes in Free and Protein-Bound SH Levels in Rat Tissues. Toxicol Mech Methods. 2006;16(7):347-52.

In addition, plasma lactate dehydrogenase levels were determined.
1(0,0,0,1) Details
7966439 Gupta RC, Goad JT, Kadel WL: Cholinergic and noncholinergic changes in skeletal muscles by carbofuran and methyl parathion. J Toxicol Environ Health. 1994 Nov;43(3):291-304.

Noncholinergic markers included high-energy phosphates (adenosine triphosphate, ATP; phosphocreatine, PCr; and their metabolites), and the activity of creatine kinase (CK) and lactate dehydrogenase (LDH) and their isoenzymes and subforms.
1(0,0,0,1) Details
10581123 Ribeiro S, Guilhermino L, Sousa JP, Soares AM: Novel bioassay based on acetylcholinesterase and lactate dehydrogenase activities to evaluate the toxicity of chemicals to soil isopods. Ecotoxicol Environ Saf. 1999 Nov;44(3):287-93.

The in vivo effects of the insecticides parathion-ethyl and endosulfan-sulfate on AChE and LDH activities of P. dilatatus under laboratory conditions were investigated.
1(0,0,0,1) Details