| Name | choline transporter |
|---|---|
| Synonyms | CHT; CHT 1; CHT1; Choline transporter; Hemicholinium 3 sensitive choline transporter; High affinity choline transporter 1; SLC5A7; Solute carrier family 5 member 7… |
| Name | parathion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20015457 | Levin ED, Timofeeva OA, Yang L, Petro A, Ryde IT, Wrench N, Seidler FJ, Slotkin TA: Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging. Behav Brain Res. 2010 Apr 2;208(2):319-27. Epub 2009 Dec 17. In association with the effects on cognitive performance, neonatal parathion exposure elicited widespread abnormalities in indices of serotonergic (5HT) and cholinergic synaptic function, characterized by upregulation of 5HT (2) receptors and the 5HT transporter, deficits in choline acetyltransferase activity and nicotinic cholinergic receptors, and increases in hemicholinium-3 binding to the presynaptic choline transporter. |
31(0,1,1,1) | Details |
| 18941570 | Slotkin TA, Bodwell BE, Ryde IT, Levin ED, Seidler FJ: Exposure of neonatal rats to parathion elicits sex-selective impairment of systems in brain regions during adolescence and adulthood. Environ Health Perspect. 2008 Oct;116(10):1308-14. Epub 2008 May 19. METHODS: We assessed neurochemical indices related to the function of synapses (choline acetyltransferase, presynaptic high-affinity choline transporter, nicotinic cholinergic receptors) in brain regions comprising all the major projections, with determinations carried out from adolescence to adulthood (PNDs 30, 60, and 100). |
1(0,0,0,1) | Details |
| 16675431 | Slotkin TA, Levin ED, Seidler FJ: Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environ Health Perspect. 2006 May;114(5):746-51. We contrasted neuritic outgrowth and cholinergic synaptic development in neonatal rats given different organophosphates (chlorpyrifos, diazinon, parathion) at doses spanning the threshold for impaired growth and viability. |
0(0,0,0,0) | Details |