| Name | GSTP1 1 |
|---|---|
| Synonyms | DFN 7; PI; DFN7; FAEES 3; FAEES3; GST class pi; GST3; GSTP 1… |
| Name | parathion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15103050 | Abel EL, Bammler TK, Eaton DL: Biotransformation of methyl parathion by glutathione S-transferases. . Toxicol Sci. 2004 Jun;79(2):224-32. Epub 2004 Apr 21. We also measured MeP O-dealkylation activities of several purified recombinant GSTs belonging to the alpha (human GSTs A1-1 and A2-2, mouse GSTA3-3, rat GSTA5-5), mu (human GSTs M1a-1a, M2-2, M3-3, M4-4), pi (human GSTP1-1, mouse GSTs P1-1, P2-2), and theta (human GSTT1-1) classes. |
1(0,0,0,1) | Details |
| 17982697 | Calaf GM, Roy D: Human drug metabolism genes in parathion-and -treated breast cells. Int J Mol Med. 2007 Dec;20(6):875-81. Among the genes altered by parathion in comparison to the control were CHST5, CHST6 and CHST7 (sulfotransferases); CYP2F1, CYP3A7 and CYP4F3 (CYPs); GSTP1, GSTT2 and MGST1 (GSTs); MT1X (metallothionein); TPMT (methyltransferase); UGT1A1 and UGT2B (UDP glycosyltransferases). |
6(0,0,1,1) | Details |
| 10794390 | Eaton DL: Biotransformation enzyme polymorphism and pesticide susceptibility. Neurotoxicology. 2000 Feb-Apr;21(1-2):101-11. Recent studies using cDNA expressed human CYPs have suggested that CYP3A4 is the principal human CYP involved in the oxidation of parathion and probably other organo (thio) (OP) insecticides and thus PM in this CYP might influence susceptibility to OP. Recently, several single nucleotide polymorphisms in human GSTP1 have also been described, and have altered activity toward several substrates. |
1(0,0,0,1) | Details |