Protein Information

Name uroporphyrinogen decarboxylase
Synonyms PCT; UPD; URO D; UROD; Uroporphyrinogen III decarboxylase; Uroporphyrinogen decarboxylase; Uroporphyrinogen III decarboxylases; Uroporphyrinogen decarboxylases

Compound Information

Name parathion
CAS

Reference List

PubMed Abstract RScore(About this table)
3138981 Lambrecht RW, Sinclair PR, Bement WJ, Sinclair JF, Carpenter HM, Buhler DR, Urquhart AJ, Elder GH: Hepatic uroporphyrin accumulation and uroporphyrinogen decarboxylase activity in cultured chick-embryo hepatocytes and in Japanese quail (Coturnix coturnix japonica) and mice treated with polyhalogenated aromatic compounds. Biochem J. 1988 Jul 1;253(1):131-8.

Other compounds, such as hexachlorobenzene, parathion, carbamazepine and nifedipine, which have been shown previously to cause uroporphyrin accumulation in these cells, did not decrease uroporphyrinogen decarboxylase activity.
6(0,0,0,6) Details
3026315 Sinclair PR, Bement WJ, Bonkovsky HL, Lambrecht RW, Frezza JE, Sinclair JF, Urquhart AJ, Elder GH: Uroporphyrin accumulation produced by halogenated biphenyls in chick-embryo hepatocytes. Biochem J. 1986 Jul 1;237(1):63-71.

We conclude that the mechanism of the uroporphyrin accumulation cannot be due to covalent binding of activated metabolites of halogenated compounds to uroporphyrinogen decarboxylase.
Piperonyl butoxide also reversed uroporphyrin accumulation caused by 3,4,5,3',4',5'-hexachlorobiphenyl, mixtures of other halogenated biphenyls, lindane, parathion, nifedipine and verapamil.
1(0,0,0,1) Details