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Zou LM, Li SY, Zhang J: [Effects of organophosphorus insecticides on G protein-coupled receptor kinase-2 mediated phosphorylation of M2 muscarinic receptors]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Jun;24(6):352-5.
PO and parathion (PT) had little effect on the receptor phosphorylation under the same conditions.
In vitro experiments, the purified mAChR2, G-protein coupled receptor kinase 2 (GRK2) and the (gamma-p32) labeled ATP were incubated with paraoxon (PO), chlorpyrifos oxon (CPO) or chlorpyrifos (CPF) of varying concentrations. |
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