Protein Information

Name apoprotein
Synonyms AD2; APOE; Apo E; Apolipoprotein E; Apolipoprotein E precursor; apoprotein; Apo Es; Apolipoprotein Es…

Compound Information

Name parathion
CAS

Reference List

PubMed Abstract RScore(About this table)
2874799 Guengerich FP: Covalent binding to apoprotein is a major fate of heme in a variety of reactions in which cytochrome P-450 is destroyed. Biochem Biophys Res Commun. 1986 Jul 16;138(1):193-8.

A major fraction of the heme label was irreversibly bound to apoprotein in all cases, including incubations with fluroxene, 1-octene, vinyl bromide, trichloroethylene, vinyl chloride, parathion, cumene hydroperoxide, NaN3, or iron-ADP complex.
33(0,1,1,3) Details
9023313 Butler AM, Murray M: Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation. J Pharmacol Exp Ther. 1997 Feb;280(2):966-73.

Transfer of the phosphorothioate thionosulfur atom to the CYP apoprotein results in amino acid modification and enzyme inactivation.
1(0,0,0,1) Details
8316222 Butler AM, Murray M: Inhibition and inactivation of constitutive cytochromes P450 in rat liver by parathion. Mol Pharmacol. 1993 Jun;43(6):902-8.

0(0,0,0,0) Details