| Name | CYP3A7 |
|---|---|
| Synonyms | Aryl hydrocarbon hydroxylase; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CP37; CYP3A7; CYPIIIA 7; CYPIIIA7… |
| Name | parathion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17110060 | Buratti FM, Leoni C, Testai E: Foetal and adult human CYP3A isoforms in the bioactivation of organophosphorothionate insecticides. Toxicol Lett. 2006 Dec 15;167(3):245-55. Epub 2006 Oct 24. Since OPT-induced neurodevelopmental effects may be due to in situ bioactivation by foetal enzymes, the catalytic activity of the foetal CYP3A7 toward chlorpyrifos (CPF), parathion (PAR), malathion (MAL) and fenthion (FEN) has been assessed by using recombinant enzymes. |
7(0,0,1,2) | Details |
| 17982697 | Calaf GM, Roy D: Human drug metabolism genes in parathion-and -treated breast cells. Int J Mol Med. 2007 Dec;20(6):875-81. Among the genes altered by parathion in comparison to the control were CHST5, CHST6 and CHST7 (sulfotransferases); CYP2F1, CYP3A7 and CYP4F3 (CYPs); GSTP1, GSTT2 and MGST1 (GSTs); MT1X (metallothionein); TPMT (methyltransferase); UGT1A1 and UGT2B (UDP glycosyltransferases). |
6(0,0,1,1) | Details |
| 4064931 | Graziano MJ, Gairola C, Dorough HW: Effects of cigarette smoke and dietary levels on selected lung and hepatic biotransformation enzymes in mice. Drug Nutr Interact. 1985;3(4):213-22. Smoking had no effect on hepatic aryl hydrocarbon hydroxylase (AHH), UDP-glucuronyltransferase, glutathione S-transferase, parathion desulfurase, or parathion esterase activity. |
0(0,0,0,0) | Details |