Protein Information

Name MT 2
Synonyms CES 1; CES1; MT 2A; MT II; MT IIa; MT 2; MT2; MT2A…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
2584191 Mehra RK, Garey JR, Butt TR, Gray WR, Winge DR: Candida glabrata metallothioneins. J Biol Chem. 1989 Nov 25;264(33):19747-53.

The concentrations of MT-II mRNA appeared to be higher than that of MT-I mRNA at all concentrations of copper sulfate tested.
14(0,0,1,9) Details
2318858 Mehra RK, Garey JR, Winge DR: Selective and tandem amplification of a member of the metallothionein gene family in Candida glabrata. J Biol Chem. 1990 Apr 15;265(11):6369-75.

Strains of C. glabrata highly resistant to copper salts were obtained by repeated culturing of wild-type isolates in medium containing increasing concentrations of copper sulfate.
Two genes, designated metallothionein-I (MT-I) and one member of the metallothionein-II family (MT-II), were cloned and sequenced previously (Mehra, R.
7(0,0,0,7) Details
1339367 Mehra RK, Thorvaldsen JL, Macreadie IG, Winge DR: Disruption analysis of metallothionein-encoding genes in Candida glabrata. Gene. 1992 May 1;114(1):75-80.


We have disrupted MT-IIa, an amplified locus, and MT-IIb, a single-copy gene, to determine the roles of various MT genes in CuSO4 resistance in C. glabrata.
5(0,0,0,5) Details
10639459 Lachke SA, Srikantha T, Tsai LK, Daniels K, Soll DR: Phenotypic switching in Candida glabrata involves phase-specific regulation of the metallothionein gene MT-II and the newly discovered hemolysin gene HLP. Infect Immun. 2000 Feb;68(2):884-95.

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19618744 Stolyar OB, Myhayliv RL, Mischuk OV: The concentration-specific response of metallothioneins in copper-loading freshwater bivalve Anodonta cygnea. Ukr Biokhim Zh. 2005;77(6):68-72.


Metallothioneins (MTs) from digestive gland of freshwater bivalve mollusc Anodonta cygnea, exposed to 10 or to 200 microg x l (-1) copper ions during 14 days, were resolved using subsequent gel-permeation and ion-exchange chromatography on MT-1 and MT-2.
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18356017 Santon A, Formigari A, Irato P: The influence of metallothionein on exposure to metals: an in vitro study on cellular models. Toxicol In Vitro. 2008 Jun;22(4):980-7. Epub 2008 Feb 13.


To investigate the different biological functions in the processes of metal homeostasis and detoxification, the levels of both MT-1 and MT-2 mRNAs have been evaluated.
1(0,0,0,1) Details
9119067 Schafer HJ, Greiner S, Rausch T, Haag-Kerwer A: In seedlings of the heavy metal accumulator Brassica juncea Cu2+ differentially affects transcript amounts for gamma-glutamylcysteine synthetase (gamma-ECS) and metallothionein (MT2). FEBS Lett. 1997 Mar 10;404(2-3):216-20.


Unexpectedly, metallothionein 2 (MT2) mRNA was decreased in response to the CuSO4 treatments.
1(0,0,0,1) Details