| Name | 5HT transporter |
|---|---|
| Synonyms | Sodium dependent serotonin transporter; OCD1; 5 hydroxytryptamine transporter; 5HT transporter; 5HTT; HTT; OCD 1; SERT… |
| Name | parathion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17035140 | Slotkin TA, Tate CA, Ryde IT, Levin ED, Seidler FJ: Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environ Health Perspect. 2006 Oct;114(10):1542-6. OBJECTIVES: We exposed neonatal rats to daily doses of diazinon or parathion on postnatal days (PND) 1-4 and evaluated 5HT receptors and the 5HT transporter in brainstem and forebrain on PND5, focusing on doses of each agent below the maximum tolerated dose and spanning the threshold for cholinesterase inhibition: 0.5, 1, or 2 mg/kg for diazinon, and 0.02, 0.05, and 0.1 mg/kg for parathion. |
82(1,1,1,2) | Details |
| 20015457 | Levin ED, Timofeeva OA, Yang L, Petro A, Ryde IT, Wrench N, Seidler FJ, Slotkin TA: Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging. Behav Brain Res. 2010 Apr 2;208(2):319-27. Epub 2009 Dec 17. In association with the effects on cognitive performance, neonatal parathion exposure elicited widespread abnormalities in indices of serotonergic (5HT) and cholinergic synaptic function, characterized by upregulation of 5HT (2) receptors and the 5HT transporter, deficits in choline acetyltransferase activity and nicotinic cholinergic receptors, and increases in hemicholinium-3 binding to the presynaptic choline transporter. |
81(1,1,1,1) | Details |
| 18773955 | Slotkin TA, Levin ED, Seidler FJ: Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood. Neurotoxicol Teratol. 2009 Jan-Feb;31(1):11-7. Epub 2008 Aug 20. In adolescence (PN30), young adulthood (PN60) and full adulthood (PN100), we measured radioligand binding to 5HT (1A) and 5HT (2) receptors, and to the 5HT transporter in the brain regions comprising all the major 5HT projections and 5HT cell bodies. |
2(0,0,0,2) | Details |