Protein Information

Name aldo keto reductase (protein family or complex)
Synonyms aldo keto reductase; aldo keto reductases

Compound Information

Name parathion
CAS

Reference List

PubMed Abstract RScore(About this table)
19800895 Hreljac I, Filipic M: Organophosphorus pesticides enhance the genotoxicity of benzo (a) pyrene by modulating its metabolism. Mutat Res. 2009 Dec 1;671(1-2):84-92. Epub 2009 Oct 2.

Addition of PT or PO increased aldo-keto reductase (AKR1C1/2) levels in the presence of BaP, while cytochrome 1A (CYP1A) mRNA expression and activity were decreased.
We have shown that the model OPs, methyl parathion (PT) and methyl paraoxon (PO), are genotoxic.
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