Protein Information

Name butyrylcholinesterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name parathion-methyl
CAS

Reference List

PubMed Abstract RScore(About this table)
17963125 Gulalp B, Gokel Y, Gumurdulu D, Seydaoglu G, Daglioglu K, Dikmen N, Karcioglu O: The effect of parathion-methyl and antidotes on parotid and pancreatic glands: a pilot experimental study. Int J Toxicol. 2007 Sep-Oct;26(5):383-8.

After the administration of the chemicals, blood samples were drawn to test for amylase, lipase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE), while pancreatic and parotid glands of each rat were removed for light microscopic examination.
1(0,0,0,1) Details
3008132 Pawlowska D, Moniuszko-Jakoniuk J, Soltys M: The effect of chronic physical exercise on the activity of hydrolytic enzymes in acute poisoning with parathion-methyl in rats. Pol J Pharmacol Pharm. 1985 Sep-Oct;37(5):639-46.

The activity of cholinesterase (ChE) in the serum, of paraoxonase--in the serum and liver, and of beta-glucuronidase (beta-gluc)--in the serum, liver and intestine were determined 1 h after the treatment.
1(0,0,0,1) Details
11750078 Howard MD, Pope CN: In vitro effects of chlorpyrifos, parathion, methyl parathion and their oxons on cardiac muscarinic receptor binding in neonatal and adult rats. Toxicology. 2002 Jan 15;170(1-2):1-10.

As effective concentrations of the oxons were relatively similar to their anticholinesterase potencies, these findings suggest that direct interaction with cardiac muscarinic receptors by some organophosphorus agents may occur at relevant exposure levels and contribute to cardiac toxicity.
1(0,0,0,1) Details
3008131 Pawlowska D, Moniuszko-Jakoniuk J, Soltys M: Parathion-methyl effect on the activity of hydrolytic enzymes after single physical exercise in rats. Pol J Pharmacol Pharm. 1985 Sep-Oct;37(5):629-38.

At 1 h after pesticide administration the activity of cholinesterase (ChE) was determined in the serum, of paraoxonase--in the serum and liver, and that of beta-glucuronidase (beta-gluc)--in the serum, liver and intestine.
1(0,0,0,1) Details
8854833 Sanchez-Fortun S, Sanz F, Barahona MV: Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae. Arch Environ Contam Toxicol. 1996 Oct;31(3):391-8.


The protective effect of the cholinergic antagonists atropine, hexamethonium, pirenzepine and 11-(2-((diethyl-amino) methyl)-1-piperidinylacetyl)-5, 11-dihydro-6H-pyrido (2,3-b)-(1,4)-benzodiazepine-6-one (AF-DX 116) and a cholinesterase-reactivating oxime 2-pyridine aldoxime methochloride (2-PAM) on the mortality due to four selected OPI in Artemia salina 24-h old was investigated.
1(0,0,0,1) Details
83128 Golbs S, Fuchs V, Leipner E, Huttel I: [The effect of pesticide combinations in laboratory rats. Arch Exp Veterinarmed. 1978;32(4):569-77.

After oral administration of pesticides Parathion-methyl, Carbaryl, Lindane and their combinations were investigated the activities of enzyme SGOT, SGPT, Alkaline Phosphatase and Cholinesterase.
12(0,0,2,2) Details
11481665 Abu-Qare AW, Abou-Donia MB: Inhibition and recovery of maternal and fetal cholinesterase enzyme activity following a single cutaneous dose of methyl parathion and diazinon, alone and in combination, in pregnant rats. J Appl Toxicol. 2001 Jul-Aug;21(4):307-16.

8(0,0,0,8) Details
19487014 Qiu J, Chen J, Ma Q, Miao Y: Development of square wave voltammetry method for the assessment of organophosphorus compound impact on the cholinesterase of Pheretima with 2,6-dichloroindophenol as a redox indicator. Chemosphere. 2009 Sep;77(1):129-32. Epub 2009 May 31.

The inhibition of ChE was assessed by measuring the enzyme activity before and after incubating with parathion-methyl.
3(0,0,0,3) Details
19674799 Tryfonos M, Papaefthimiou C, Antonopoulou E, Theophilidis G: Comparing the inhibitory effects of five protoxicant organophosphates (azinphos-methyl, parathion-methyl, chlorpyriphos-methyl, methamidophos and diazinon) on the spontaneously beating auricle of Sparus aurata: an in vitro study. Aquat Toxicol. 2009 Sep 14;94(3):211-8. Epub 2009 Jul 16.

In a previous pilot study, the anticholinesterase effects of paraoxon on the heart of Sparus aurata were examined [Tryfonos, M., Antonopoulou, E., Papaefthimiou, C., Chaleplis, G., Theophilidis, G., 2009.
2(0,0,0,2) Details
3247000 Nagymajtenyi L, Desi I, Lorencz R: Neurophysiological markers as early signs of organophosphate neurotoxicity. Neurotoxicol Teratol. 1988 Sep-Oct;10(5):429-34.

The central and peripheral nervous system effects of acute and subchronic exposure to three organic phosphoro-acid esters (dimethoate, dichlorvos, parathion-methyl) were studied.
Cholinesterase activity was measured in blood, brain and other organs.
2(0,0,0,2) Details