| 9118630 |
Grangsjo A, Leijon-Kuligowski A, Torma H, Roomans GM, Lindberg M: Different pathways in irritant contact eczema? Early differences in the epidermal elemental content and expression of cytokines after application of 2 different irritants. Contact Dermatitis. 1996 Dec;35(6):355-60.
With reverse transcription polymerase chain reaction, the mRNA expression of interleukin-1 alpha (IL-1 alpha), -1 beta (IL-1 beta), -6 (IL-6), and -8 (IL-8), tumor necrosis factor alpha (TNF alpha) and granulocyte macrophage colony stimulating factor (GM-CSF) in shave biopsies from irritated and unexposed skin was studied at 0. 4. 8 and 24 h. |
1(0,0,0,1) |
Details |
| 20428187 |
Clemmensen A, Andersen KE, Clemmensen O, Tan Q, Petersen TK, Kruse TA, Thomassen M: Genome-wide expression analysis of human in vivo irritated epidermis: differential profiles induced by sodium lauryl sulfate and nonanoic acid. J Invest Dermatol. 2010 Sep;130(9):2201-10. Epub 2010 Apr 29.
Gene expression analysis using high-density oligonucleotide microarrays (representing 47,000 transcripts) revealed essentially different pathway responses (1/2) hours after exposure: NON transiently induced the IL-6 pathway as well as a number of mitogen-activated signaling cascades including extracellular signal-regulated kinase and growth factor receptor signaling, whereas SLS transiently downregulated cellular energy metabolism pathways. |
1(0,0,0,1) |
Details |