| Name | DT diaphorase |
|---|---|
| Synonyms | Diaphorase; DHQU; DIA 4; DIA4; DT diaphorase; DTD; Diaphorase (NADH/NADPH); Diaphorase (NADH/NADPH) (cytochrome b 5 reductase)… |
| Name | dichlone |
|---|---|
| CAS | 2,3-dichloro-1,4-naphthalenedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3145044 | Elliott AJ, Pardini RS: Modulation of hepatic cytochrome P-450 and DT-diaphorase by oral and sub-cutaneous administration of the pro-oxidant fungicide dichlone (2,3-dichloro-1,4-naphthoquinone). Bull Environ Contam Toxicol. 1988 Aug;41(2):164-71. |
31(0,1,1,1) | Details |
| 8024324 | Babich H, Palace MR, Borenfreund E, Stern A: Naphthoquinone cytotoxicity to bluegill sunfish BF-2 cells. Arch Environ Contam Toxicol. 1994 Jul;27(1):8-13. Apparently, in the HepG2, as compared to the BF-2, cells, 1,4-NQ was metabolized by DT-diaphorase in a reaction involving a two electron reduction. Bluegill sunfish BF-2 fibroblasts were used to evaluate the in vitro cytotoxicities of 1,4-naphthoquinone (NQ), 5,8-dihydroxy-1,4-NQ, and 2,3-dichloro-1, 4-NQ (dichlone); comparisons were made with previously obtained data on the response of human hepatoma HepG2 cells. |
1(0,0,0,1) | Details |
| 7574883 | Ahmad S, Zaman K, MacGill RS, Batcabe JP, Pardini RS: Dichlone-induced oxidative stress in a model insect species, Spodoptera eridania. Arch Environ Contam Toxicol. 1995 Nov;29(4):442-8. The increases as compared to control were: 5.3-, 1.9-, 3.2-, 2.6-, 2.8-, and 3.5-fold higher for superoxide dismutase, catalase, glutathione transferase and its peroxidase activity, glutathione reductase and DT-diaphorase, respectively. |
1(0,0,0,1) | Details |