| 9865506 |
Coudore-Civiale MA, Courteix C, Eschalier A, Fialip J: Effect of tachykinin receptor antagonists in experimental neuropathic pain. Eur J Pharmacol. 1998 Nov 20;361(2-3):175-84.
The intrathecal effect of 0.1 to 10 microg of RP-67,580 (3aR,7aR)-7,7-diphenyl-2 [1-imino-2 (2-methoxyphenyl)-ethyl]++ +perhydroisoindol-4-one hydrochloride, CP-96,345 (2S,3S)-cis-(2 (diphenylmethyl)-N-[(2-methoxyphenyl) methyl]-1-azabicyclo [2.2.2] octan-3-amine), SR-140,333 (S)-(1- inverted question mark2-[3-(3,4-dichlorophenyl)- 1-(3-isopropoxyphenylacetyl) piperidin-3-yl] ethyl inverted question mark-4-phenyl-1 -azonia-bicyclo [2.2.2.]-octane,chloride), all neurokinin (NK) 1-receptor antagonists, SR-48,968 (S)-N-methyl-N [4-(4-acetylamino-4-[phenylpiperidino)-2-(3,4-dichlorophen yl)-butyl] benzamide, a tachykinin NK2 receptor antagonist and SR-142,801 (S)-(N)-(1-(3-(1-benzoyl-3-(3,4-dichlorophenyl) piperidin-3-yl) propyl)-4-phenylpiperidin-4-yl)-N-methyl acetamide, a tachykinin NK3 receptor antagonist, and of their respective inactive enantiomers on thresholds of vocalization due to a mechanical stimulus in mononeuropathic (sciatic nerve ligature) and diabetic rats, was examined. |
31(0,1,1,1) |
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| 9851584 |
Hsu TH, Lai YL, Kou YR: Acetylcholine and tachykinin receptor antagonists attenuate wood smoke-induced bronchoconstriction in guinea pigs. Eur J Pharmacol. 1998 Nov 6;360(2-3):175-83.
The smoke-induced changes in RL and Cdyn were significantly attenuated by pretreatment with atropine, CP-96,345 [(2S,3S)-cis-2-(diphenylmethyl)-N-((2-methoxyphenyl)-methyl)-1-aza bicyclo (2.2.2.)-octan-3-amine; a tachykinin NK1 receptor antagonist], and SR-48,968 [(S)-N-methyl-N (4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophen yl)-butyl) benzamide; a tachykinin NK2 receptor antagonist] in combination, atropine alone, and SR-48,968 alone, but were not significantly affected by pretreatment with the inactive enantiomers of CP-96,345 and SR-48,968, CP-96,345 alone, indomethacin (a cyclooxygenase inhibitor), and MK-571 [((3-(3-(2-(7-chloro-2-quinolinyl) ethenyl) phenyl ((3-dimethyl amino-3-oxo-propyl) thio) methyl) propanoic acid; a leukotriene D4 receptor antagonist]. |
0(0,0,0,0) |
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